Glycosidic flavonoids and their potential applications in cancer research: a review

Abstract

Purpose of review Every year, the cancer patient registry increases, and the leading cause of death in a global context. Plant-based molecules are gaining attention in cancer research due to the side effects of chemotherapy. A glycosidic derivative of flavonoid (GDF) plays a significant role in cancer proliferation mechanisms. GDF inhibits cell proliferation by elevating the expression of apoptotic proteins, altering the expression of nuclear factor-kappa B (NF- κB), and decreasing mitochondrial membrane potential (Δψm) in cancer cells. Recent findings Reported studies on the flavonoids orientin, vitexin, prunetionoside, chrysin, and scutellarein increased attention and are being widely investigated for their potential role in different parts of cancer research. Prunetionoside is a flavonoid with high cytotoxic potential and capable of inducing necroptosis in AGS gastric cancer cells. Similarly, scutellarein is a flavonol, induces an extrinsic apoptotic pathway and downregulates the expression level of cyclin proteins in HepG2 liver cancer cells. Vitexin is reported to be capable of deregulating the expression levels of p-Akt, p-mTOR, and p-PI3K in A549 lung cancer cells. Orientin inhibits IL-8 expression and invasion in MCF-7 breast cancer cells by suppressing MMP-9 in the presence of TPA via STAT3/AP-1/ERK/PKCα-mediated signaling pathways. It also induces mitochondria-mediated intrinsic apoptosis and G0/G1 cell cycle arrest in HT29 colon cancer cells. Chrysin is a flavonoid present in honey that has been shown to play an important role in cervical and colon cancer by suppressing the AKT/mTOR/PI3K pathway and increasing ROS accumulation, LDH leakage, respectively.

In-Vitro Cytotoxicity, Apoptotic Property, and Gene Expression Changes Induced by Naringenin-7-O-Glucoside in Triple-Negative Breast Cancer

“…Prunetionoside, a flavonoid compound, has potent cytotoxic effects and can cause necroptosis in AGS gastric cancer cells. Similarly, scutellarein, another flavonol, initiates an extrinsic pathway of apoptosis in HepG2 liver cancer cells and decreases the expression of cyclin protein [ 28 ]. In the optimization of therapy and in the search for new anticancer agents, the biological potential, bioavailability, cost-effectiveness, and minimal side effects of flavonoids make them promising cytotoxic anticancer agents.…”

Neuropharmacological and anxiolytic effects of extracts of Passiflora tripartita var. mollissima on mice

“…Ramos et al (2010), found the flavonoid orientin in an ethanolic leaf extract of Passiflora tripartita. This flavonoid was studied by Abusaliya et al (2022), and found that it has an application in the treatment against cancer. The administration of orientin-containing nanoparticles in mice was reported to provide antidepressive activity in mice (Alves et al, 2020).…”

Flavonoids in safflower extract reduce cisplatin-induced damage to human follicle dermal papilla cells by inhibiting DNA damage and Rad17/Chk1/Cdc25C signaling

“…However, since flavonoid compounds can reduce the DNA damage caused by cisplatin, whether they affect the ability of cisplatin to kill cancer cells still needs further investigation. A literature review presented that the flavonoids in many plant extracts can promote the apoptosis of gastric cancer cell lines (Lee et al, 2012;Bhosale et al, 2021;Abusaliya et al, 2022). These studies demonstrated that flavonoids can stall the progression of the G2→M cell cycle in AGS gastric cancer cell lines and then cause apoptosis.…”