Glycosylated haemoglobin and coronary atherosclerosis in non-diabetic patients: is it a prognostic factor?

Ajudani, Reza; Rezaee‐Zavareh, Mohammad Saeid; Karimi‐Sari, Hamidreza; Safiabadi, Mahdi; Dolatimehr, Fardin; Okhovatian, Mohammadreza; Ramezani-Binabaj, Mahdi; Pishgoo, Bahram

doi:10.1080/00015385.2017.1306309

Cited by 12 publications

(10 citation statements)

References 16 publications

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“…Some previous studies have shown consistent results with ours investigating correlation between HbA1c and CACS progression or coronary atherosclerosis. Reza Ajudani, in a cross-sectional study based on 411 patients without history of known diabetes mellitus, reported that HbA1c may be functioning as an independent diagnostic factor in nondiabetic patients with severe coronary atherosclerosis [27]. Besides, Wenhui Zhao et al used African American and white diabetic patients as the study population and obtained similar results [28].…”

Section: Discussionmentioning

confidence: 83%

Nonlinear relationship between HbA1c and coronary artery calcium score progression: a secondary analysis based on a retrospective cohort study

Gao

2021

Diabetol Metab Syndr

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Objective Coronary artery calcium score and glycated hemoglobin(HbA1c) are both considered risk factors for coronary heart disease. However, the relationship between coronary artery calcium score and HbA1c is still unclear. Consequently, the present study was undertaken to explore HbA1c association with coronary artery calcium score progression in South Korea. Methods This study is a secondary analysis based on a retrospective cohort study in which 8151 participants received Health examination kits at the Health Promotion Center, Samsung Medical Center in Seoul, South Korea, from March 1, 2003–December 31, 2013. Cox proportional-hazards regression model was then used to evaluate the independent relationship between HbA1c and coronary artery calcium score progression. Results After adjusting potential confounding factors (age, sex, BMI, height, weight, SBP, DBP, TC, LDL-C, HDL-C, triglycerides, smoking status, alcohol consumption, reflux esophagitis status, hypertension, diabetes, dyslipidemia, ischemic heart disease and cerebrovascular disease), it was revealed that there was a nonlinear relationship between HbA1c and coronary artery calcium score progression, while the scoring point was 5.8%. The effect size was 2.06 to the left of the inflection point, while the 95% CI was 1.85 to 2.29. Whereas, the effect size was 1.04, on the right side of the inflection point while 95% CI was 0.99 to1.10. Conclusion The relationship between HbA1c and coronary artery calcium score progression is nonlinear. HbA1c is positively related to coronary artery calcium score progression when HbA1c level was less than 5.8%.

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Section: Discussionmentioning

confidence: 83%

Nonlinear relationship between HbA1c and coronary artery calcium score progression: a secondary analysis based on a retrospective cohort study

Gao

2021

Diabetol Metab Syndr

View full text Add to dashboard Cite

show abstract

“…Some previous studies have shown the consistent results with ours investigating correlation between HbA1c and coronary artery calcium score progression or coronary atherosclerosis. Based on 411 patients without history of known diabetes mellitus, Reza Ajudani reported that HbA1c may be an independent diagnostic factor in non-diabetic patients with severe coronary atherosclerosis in a cross-sectional study [19]. Besides, Wenhui Zhao et al used African American and white diabetic patients as the study population and obtained similar results [20].…”

Section: Discussionmentioning

confidence: 86%

“…First, the sample size of this study was relatively large. Seconde, previous articles that also studied HbA1c and coronary artery calcium score or coronary atherosclerosis did not clarify the nonlinear relationship [19,20,[24][25][26][27][28][29]. To the best of our knowledge, this is the rst time that a non-linear relationship has been reported and an in ection point has been determined and explained in exploring the correlation between HbA1c and coronary artery calcium score progression.…”

Section: Discussionmentioning

confidence: 88%

Nonlinear Relationship Between HbA1c and Coronary Artery Calcium Score Progression: A Secondary Analysis Based on a Retrospective Cohort Study

Gao

2021

Preprint

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ObjectiveSome previous studies was to clarify the correlation between glycated hemoglobin(HbA1c) and coronary heart disease (CHD) and the evidence regarding the correlation was still debated. However, there are fewer scientific dissertations about the correlation between HbA1c and coronary artery calcium score progression. Consequently, the present study was undertaken to explore the link of HbA1c on coronary artery calcium score progression in South Korea.MethodsThis study is a secondary analysis based on a retrospective cohort study. 8151 participants received a health check-up program at the Health Promotion Center of the Samsung Medical Center in Seoul, South Korea, from March 1, 2003 to December 31, 2013. We then used Cox proportional-hazards regression model to evaluate the independent relationship between HbA1c and coronary artery calcium score progression.ResultsAfter adjusting potential confounders (age, sex, BMI, height, weight, SBP, DBP, TC, LDL-C, HDL-C, triglycerides,smoking status, alcohol consumption, reflux esophagitis status, hypertension, diabetes, dyslipidemia, ischemic heart disease and cerebrovascular disease), non-linear relationship was detected between HbA1c and coronary artery calcium score progression, whose point was 5.8%. The effect sizes and the confidence intervals on the left and right sides of inflection point were 2.05 (1.85 to 2.27) and 1.04 (0.99 to 1.10) , respectively. ConclusionThe relationship between HbA1c and coronary artery calcium score progression is non-linear. HbA1c is positively related with coronary artery calcium score progression when HbA1c was less than 5.8%.

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“…The ideal cut-off value of HbA1c for the formation of coronary artery disease was found to be 5.6% (sensitivity: 60.5%, speci city: 52%) (13). In a study with 411 patients in recent years, based on the ROC curve, the cut-off value of HbA1c between patients with and without coronary atherosclerosis was found to be 5.45% (82.8% sensitivity and 62.7% speci city) (14). In our study, ROC analysis was used and HbA1c cut-off value was 91.55% sensitivity and 61.39% speci city was 5.6% in determining atherosclerotic patients.…”

Section: Discussionmentioning

confidence: 99%

Glycosylated Haemoglobin A1c as An Independent Marker Predicting Coronary Artery Disease in Non-diabetic Patient Population in Primary Healthcare in Turkey: A crosssectional study

Kayali¹,

Özder²

2020

Preprint

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Background: In our role as a preventive physician, there is a need for cheap and accessible biochemical markers that will allow the determination of the risk of coronary artery disease. We aimed to research the value of glycosylated haemoglobin (HbA1c) in the prediction of coronary artery disease. Methods: Patients aged between thirty and ninety years who were admitted to outpatient clinic of Cardiology department in a university hospital between January 2016 and June 2018 for angiography for various reasons were retrospectively screened. Patients with known diabetes or patients with HbA1c of 6.5 or above were excluded from the study. Comparative HbA1c data were obtained according to the stenosis groups and statistical significance was sought. Logistic regression analysis was used to investigate the risk factors affecting stenosis positivity. Results: A total of 247 patients were identified, 120 patients without any stenosis in any coronary artery, 56 patients with> 50% stenosis in one coronary artery, and 71 patients with > 50% stenosis in more than one coronary artery. There was a statistically significant difference between HbA1c measurements according to the degree of stenosis (p = 0.001 and p <0.01, respectively). The odd ratio for HbA1c was 6.260 (95% CI: 3,160-12,401). According to the stenosis positivity, the cut off point for HbA1c was found to be 5.6 and above. In the regression analysis, HbA1c was an independent risk factor for coronary artery disease. One unit increase in HbA1c measurements increases the risk of stenosis positive to 12.424 times (95% CI: 5,990-25,767).Conclusions: The study showed HbA1c can be used as an independent marker in determining the probability and severity of coronary artery disease in non-diabetic individuals and as an useful marker in primary care predicting coronary artery disease (CAD).

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Glycosylated haemoglobin and coronary atherosclerosis in non-diabetic patients: is it a prognostic factor?

Abstract: The present study demonstrated that HbA1c might be an independent diagnostic factor in non-diabetic patients with severe coronary atherosclerosis.

Cited by 12 publications

References 16 publications

Nonlinear relationship between HbA1c and coronary artery calcium score progression: a secondary analysis based on a retrospective cohort study

Nonlinear relationship between HbA1c and coronary artery calcium score progression: a secondary analysis based on a retrospective cohort study

Nonlinear Relationship Between HbA1c and Coronary Artery Calcium Score Progression: A Secondary Analysis Based on a Retrospective Cohort Study

Glycosylated Haemoglobin A1c as An Independent Marker Predicting Coronary Artery Disease in Non-diabetic Patient Population in Primary Healthcare in Turkey: A crosssectional study

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