Glycosylated Hemoglobin Levels in a Benign Form of Sickle Cell Anemia in Saudi Arabia

Alayash, A.I.; Dafallah, Abdullah A.; Al-Husayni, Husayn; Al-Ali, Amein K.; Al-Quorain, Abdulaziz; Omer, Awad; Wilson, Moira; Bonaventura, J.; Cashon, Robert E.

doi:10.1159/000206111

Cited by 10 publications

(7 citation statements)

References 20 publications

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“…GHB in the sickle cell anemia patients expressed as a percentage of the control level is 81 %. This is close to the 90% re ported in Saudi [8] and Nigerian patients [3], but it is significantly higher than the 58% reported in an Amer ican Black group of patients [9]. The near normal lev els of GHB in Saudi SCA patients have been attrib uted to a benign course of the disease brought about by prolongation of RBC survival due to persistence of HbF.…”

Section: Discussionsupporting

confidence: 68%

Glycosylated Hemoglobin Levels in Sudanese Sickle Cell Anemia Patients

Atabani

Hassan²,

Rahman³

et al. 1989

Acta Haematol

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Glycosylated hemoglobin was measured, by a colorimetric method, in 49 patients with sickle cell anemia attending Khartoum Teaching Hospital. The level obtained (4.9%, SD 1.3) was significantly lower than the control value (5.6%, SD 0.2; p < 0.0025). Expressed as percentage of the control value, the glycosylated hemoglobin level in these patients was 81 %. This falls midway between the 90% reported in a benign form of sickle cell anemia in Saudi Arabia and the 58% reported in a severe form in an American Black group, which gives support to the observed heterogeneity of sickle cell anemia. Alternatively, glycosylated hemoglobin level in 27 subjects with sickle cell trait (5.6%, SD 0.2) was identical to that of the controls. The state of hemolysis in the sickle cell anemia patients, as indicated by bilirubin levels, did not correlate with the glycosylated hemoglobin values. Although glycosylated hemoglobin measurement is affected by red cell survival, it does not reflect the state of ongoing hemolysis.

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Section: Discussionsupporting

confidence: 68%

Glycosylated Hemoglobin Levels in Sudanese Sickle Cell Anemia Patients

Atabani

Hassan²,

Rahman³

et al. 1989

Acta Haematol

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“…This fact is important as it provides a baseline for comparison with glycosylated haemoglobin levels in patients with shortened red cell life-span as in the case of some haemolytic anaemias known to be prevalent in the Eastern Province of Saudi Arabia. ": 22 The levels of glycosylated haemoglobin in 81 newly born infants from healthy mothers were significantly lower (4·1 % ) than in normal adults (4'9%). This is due to the shortened life-span of the young erythrocytes (neocytes) and to a concomitant reticulocytosis in fetuses compared to adnlts.?…”

Section: Glycosylated Haemoglobin In Saudi Arabs 281mentioning

confidence: 87%

Determination of Glycosylated Haemoglobin in Normal, Newborn and Diabetic Saudi Arabs

Alayash

Dafallah²,

Al-Husayni³

et al. 1987

Ann Clin Biochem

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SUMMARY. Colorimetric determinations of glycosylated haemoglobin by the thiobarbituric acid method were carried out in normal adults (n=142), newly born infants of healthy mothers (n=81), and in a group of patients with diabetes mellitus (n= 124). The glycosylated haemoglobin level in normal adult males was 4·9%, which is close to that reported for other populations. No correlation was found between age and the levels of glycosylated haemoglobin in males over 10 years old. However, the mean value for glycosylated haemoglobin in cord blood was 4·1%, significantly different from that of adults. The range values for glycosylated haemoglobin in diabetic patients was 7-1lJ'Yo. The mean value for glycosylated haemoglobin was 10.9°/." similar to that established in other diabetic populations. Results of colorimetric determinations of glycosylated haemoglobin in the Saudi population compare well with other ethnic groups and, therefore, suggest no ethnic differences in glycosylated haemoglobin levels.

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“…An increase in the redox potential in sickle erythrocytes will probably reduce the rate of formation of methemoglobin and thus reduce the denaturation of HbS [5]. Previously, it has been reported that the level of 2,3 diphosphoglycerate (2,3 DPG), a potent inhibitor of glycolysis, is significantly elevated in both Saudis and African Americans with SCD [21, 22]. However, the value of 2,3 DPG in Saudis is not as highly elevated as in the case of African Americans with SCD [23].…”

Section: Discussionmentioning

confidence: 99%

Pyridine Nucleotide Redox Potential in Erythrocytes of Saudi Subjects with Sickle Cell Disease

Al-Ali¹

2002

Acta Haematol

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Key antioxidant defense reactions in RBCs are linked to nicotinamide adenine dinucleotide (NAD⁺) and nicotinamide adenine dinucleotide phosphate (NADP⁺). The ratio of reduced (NAD(P)H) to total pyridine nucleotide pool [(NAD(P)_T i.e. NAD(P)H plus NAD(P)⁺], which is known as redox potential, reflects the redox status of erythrocytes. Through the utilization of a spectrophotometric cycling assay, the NAD⁺ and NADP⁺ redox potentials were determined in erythrocytes from normal Saudi subjects and those with sickle cell disease (SCD). The sickle erythrocytes NADH/NAD_T ratio (0.386) was reduced compared to the normal ratio (0.464). This reduction appears to be due to a significant increase in oxidized NAD⁺ in sickle RBCs. However, the value of the redox potential of erythrocytes in Saudi subjects with SCD is slightly higher than that reported for comparable African Americans. Although the high fetal hemoglobin is the main factor in the amelioration of the clinical course exhibited by Saudi sickle cell patients, it is assumed that the slight improvement in the redox potential may play a part in this process. This is supported by a relatively uninhibited glycolytic pathway in the erythrocytes of Saudi subjects with SCD with a higher level of NADH than their African American counterparts.

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Glycosylated Hemoglobin Levels in a Benign Form of Sickle Cell Anemia in Saudi Arabia

Cited by 10 publications

References 20 publications

Glycosylated Hemoglobin Levels in Sudanese Sickle Cell Anemia Patients

Glycosylated Hemoglobin Levels in Sudanese Sickle Cell Anemia Patients

Determination of Glycosylated Haemoglobin in Normal, Newborn and Diabetic Saudi Arabs

Pyridine Nucleotide Redox Potential in Erythrocytes of Saudi Subjects with Sickle Cell Disease

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