Glycosylation of blood cells during the onset and progression of atherosclerosis and myocardial infarction

Ferro, Federico; Spelat, Renza; Pandit, Abhay; Martin-Ventura, José L.; Rabinovich, Gabriel A.; Contessotto, Paolo

doi:10.1016/j.molmed.2023.11.013

Cited by 5 publications

(1 citation statement)

References 119 publications

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“…CVDs, which are classified according to affected sites and involve various cell types, encompass a spectrum of conditions including cardiomyopathy, arrhythmia, atherosclerosis (AS), cardiac fibrosis, heart failure, coronary artery disease, and hypertension [2,3]. Current research indicates that the interaction between cells and the extracellular matrix (ECM) plays a significantly pivotal role in the pathogenesis of CVDs [4][5][6][7]. Notably, specific focus has been directed toward dysregulated ligands that target integrins, which emphasizes their unique relevance in the context of cardioprotection [8].…”

Section: Introductionmentioning

confidence: 99%

Roles of Integrin in Cardiovascular Diseases: From Basic Research to Clinical Implications

Zhang,

et al. 2024

IJMS

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Cardiovascular diseases (CVDs) pose a significant global health threat due to their complex pathogenesis and high incidence, imposing a substantial burden on global healthcare systems. Integrins, a group of heterodimers consisting of α and β subunits that are located on the cell membrane, have emerged as key players in mediating the occurrence and progression of CVDs by regulating the physiological activities of endothelial cells, vascular smooth muscle cells, platelets, fibroblasts, cardiomyocytes, and various immune cells. The crucial role of integrins in the progression of CVDs has valuable implications for targeted therapies. In this context, the development and application of various integrin antibodies and antagonists have been explored for antiplatelet therapy and anti-inflammatory-mediated tissue damage. Additionally, the rise of nanomedicine has enhanced the specificity and bioavailability of precision therapy targeting integrins. Nevertheless, the complexity of the pathogenesis of CVDs presents tremendous challenges for monoclonal targeted treatment. This paper reviews the mechanisms of integrins in the development of atherosclerosis, cardiac fibrosis, hypertension, and arrhythmias, which may pave the way for future innovations in the diagnosis and treatment of CVDs.

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Section: Introductionmentioning

confidence: 99%

Roles of Integrin in Cardiovascular Diseases: From Basic Research to Clinical Implications

Zhang,

et al. 2024

IJMS

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Clinical glycoproteomics: methods and diseases

Wang,

Lei,

Zhao

et al. 2024

MedComm

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Glycoproteins, representing a significant proportion of posttranslational products, play pivotal roles in various biological processes, such as signal transduction and immune response. Abnormal glycosylation may lead to structural and functional changes of glycoprotein, which is closely related to the occurrence and development of various diseases. Consequently, exploring protein glycosylation can shed light on the mechanisms behind disease manifestation and pave the way for innovative diagnostic and therapeutic strategies. Nonetheless, the study of clinical glycoproteomics is fraught with challenges due to the low abundance and intricate structures of glycosylation. Recent advancements in mass spectrometry‐based clinical glycoproteomics have improved our ability to identify abnormal glycoproteins in clinical samples. In this review, we aim to provide a comprehensive overview of the foundational principles and recent advancements in clinical glycoproteomic methodologies and applications. Furthermore, we discussed the typical characteristics, underlying functions, and mechanisms of glycoproteins in various diseases, such as brain diseases, cardiovascular diseases, cancers, kidney diseases, and metabolic diseases. Additionally, we highlighted potential avenues for future development in clinical glycoproteomics. These insights provided in this review will enhance the comprehension of clinical glycoproteomic methods and diseases and promote the elucidation of pathogenesis and the discovery of novel diagnostic biomarkers and therapeutic targets.

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Central role of Galectin-3 at the cross-roads of cardiac inflammation and fibrosis: Implications for heart failure and transplantation

Seropian,

El-Diasty,

El-Sherbini

et al. 2024

Cytokine & Growth Factor Reviews

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Glycosylation of blood cells during the onset and progression of atherosclerosis and myocardial infarction

Cited by 5 publications

References 119 publications

Roles of Integrin in Cardiovascular Diseases: From Basic Research to Clinical Implications

Roles of Integrin in Cardiovascular Diseases: From Basic Research to Clinical Implications

Clinical glycoproteomics: methods and diseases

Central role of Galectin-3 at the cross-roads of cardiac inflammation and fibrosis: Implications for heart failure and transplantation

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