Glycosylation of silybin

Antioxidant and antiviral activities of silybin fatty acid conjugates

“…A number of silybin water-soluble semisynthetic derivatives were designed to overcome this problem, e.g., silybin bis-hemisuccinate (Legalon) [16], silybin-23-O-phosphate [17], silybin 23-O-b-glycosides [6], and silybinic acid [9]. However, modifications of silybin leading to an increase in its water-solubility usually led to an impairment of its antioxidant (antiradical) activity in the lipophilic milieu [9].…”

Microbial transformation of silybin by Trichoderma koningii

“…It was interesting to note that production of 3-O-glycosides was readily achieved by microbial transformation, while the secondary alcohol at C-3 has been reported to be partially substituted by chemical synthetic methods only under prolonged reaction times with formation of small amounts of 3,9 0 -diglycosides. 7 Production of silybin analogues using microbial metabolic transformation has never been reported yet. This is the first report on the presence and unambiguous structure elucidation of silybin …”

Silymarin: What is in the name …? An appeal for a change of editorial policy

“…13 It is interesting to note that the diastereomers of silybin, prepared recently as pure compounds by our group, clearly have different pharmacokinetic profiles. 14,15 It is possible that these diasteromers interact in different ways with receptors to which silybin is known to bind (liver receptors for ␣-amanitin, receptors for steroids?). Controversy also surrounds the activity of these compounds in animals (mostly rodents).…”