2024
DOI: 10.1093/mtomcs/mfae019
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Glycyl-l-histidyl-l-lysine prevents copper- and zinc-induced protein aggregation and central nervous system cell death in vitro

Jin-Hong Min,
Heela Sarlus,
Robert A Harris

Abstract: Common features of neurodegenerative diseases are oxidative and inflammatory imbalances as well as the misfolding of proteins. An excess of free metal ions can be pathological and contribute to cell death, but only copper and zinc strongly promote protein aggregation. Herein we demonstrate that the endogenous copper binding tripeptide Glycyl-L-Histidyl-L-Lysine (GHK) has the ability to bind to and reduce copper redox activity, and to prevent copper and zinc induced cell death in vitro. In addition, GHK prevent… Show more

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