Glycyrrhetinic acid-decorated and docetaxel-loaded thermosensitive liposomes for combination therapy against hepatocellular carcinoma

Zhu, Xiali; Huang, Shengnan; Li, Linghua; Wang, Shasha; Chen, Jiaqi; Guan, Yanbin; Wang, Baiyan; Jia, Yongyan

doi:10.1007/s11051-021-05273-7

Cited by 6 publications

(1 citation statement)

References 32 publications

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“…The research on docetaxel-loaded liposomes decorated with GA went further by co-loading copper sulfide nanoparticles which rendered the nanoformulation thermosensitive; thus, upon injection in liver tumor-bearing mice, the modified liposomes increased drug accumulation at the tumor site and actively targeted liver cells while the copper sulfide enhanced the release of the active compound after being NIR irradiated. The modified liposomal formulation can be used for photothermal therapy combined with chemotherapy thus exhibiting a significantly improved inhibitory activity of tumor growth as well as lower toxicity [260]. A similar study used GA as liver targeting ligand for wogonin-loaded liposomes (GA-WG-Lip); the liposomes were prepared by the reverse evaporation method using the same 18-GA-Suc derivative, only this time the active drug, being water soluble, was emulsified in the lipid solution, after which the solvent was removed through vacuum evaporation.…”

Section: Glycyrrhetinic Acidmentioning

confidence: 99%

The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges

Milan

Mioc

Prodea

et al. 2022

IJMS

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The last decade has witnessed a sustained increase in the research development of modern-day chemo-therapeutics, especially for those used for high mortality rate pathologies. However, the therapeutic landscape is continuously changing as a result of the currently existing toxic side effects induced by a substantial range of drug classes. One growing research direction driven to mitigate such inconveniences has converged towards the study of natural molecules for their promising therapeutic potential. Triterpenes are one such class of compounds, intensively investigated for their therapeutic versatility. Although the pharmacological effects reported for several representatives of this class has come as a well-deserved encouragement, the pharmacokinetic profile of these molecules has turned out to be an unwelcomed disappointment. Nevertheless, the light at the end of the tunnel arrived with the development of nanotechnology, more specifically, the use of liposomes as drug delivery systems. Liposomes are easily synthesizable phospholipid-based vesicles, with highly tunable surfaces, that have the ability to transport both hydrophilic and lipophilic structures ensuring superior drug bioavailability at the action site as well as an increased selectivity. This study aims to report the results related to the development of different types of liposomes, used as targeted vectors for the delivery of various triterpenes of high pharmacological interest.

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Section: Glycyrrhetinic Acidmentioning

confidence: 99%