Glycyrrhiza glabra (Licorice) root extract attenuates doxorubicin-induced cardiotoxicity via alleviating oxidative stress and stabilising the cardiac health in H9c2 cardiomyocytes

Upadhyay, Shishir; Mantha, Anil K.; Dhiman, Monisha

doi:10.1016/j.jep.2020.112690

Cited by 65 publications

(27 citation statements)

References 36 publications

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“…glabra extracts have shown cardioprotective properties both in vitro and in vivo via the improvement of endogenous antioxidant defense mechanisms (Ojha et al, 2013;Upadhyay et al, 2020). In DOX-induced toxicity in cardiomyocytes, licorice aqueous extract has improved sirtuin (SIRT)-1, a cardioprotective transcription factor, and its downstream proteins, peroxisomes proliferator-activated receptors (PPAR)a/g (Upadhyay et al, 2020). Glycyrrhizic acid has demonstrated an inhibitory effect on the long-lasting (L)-type calcium channels of cardiomyocytes.…”

Section: Grape and Raisin (Vitis Vinifera L)mentioning

confidence: 99%

An Evaluation of Traditional Persian Medicine for the Management of SARS-CoV-2

Bahramsoltani

Rahimi

2020

Front. Pharmacol.

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A new coronavirus causing severe acute respiratory syndrome (SARS-CoV-2) has emerged and with it, a global investigation of new antiviral treatments and supportive care for organ failure due to this life-threatening viral infection. Traditional Persian Medicine (TPM) is one of the most ancient medical doctrines mostly known with the manuscripts of Avicenna and Rhazes. In this paper, we first introduce a series of medicinal plants that would potentially be beneficial in treating SARS-CoV-2 infection according to TPM textbooks. Then, we review medicinal plants based on the pharmacological studies obtained from electronic databases and discuss their mechanism of action in SARS-CoV-2 infection. There are several medicinal plants in TPM with cardiotonic, kidney tonic, and pulmonary tonic activities, protecting the lung, heart, and kidney, the three main vulnerable organs in SARS-CoV-2 infection. Some medicinal plants can prevent “humor infection”, a situation described in TPM which has similar features to SARS-CoV-2 infection. Pharmacological evaluations are in line with the therapeutic activities of several plants mentioned in TPM, mostly through antiviral, cytoprotective, anti-inflammatory, antioxidant, and anti-apoptotic mechanisms. Amongst the primarily-introduced medicinal plants from TPM, rhubarb, licorice, garlic, saffron, galangal, and clove are the most studied plants and represent candidates for clinical studies. The antiviral compounds isolated from these plants provide novel molecular structures to design new semisynthetic antiviral agents. Future clinical studies in healthy volunteers as well as patients suffering from pulmonary infections are necessary to confirm the safety and efficacy of these plants as complementary and integrative interventions in SARS-CoV-2 infection.

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Section: Grape and Raisin (Vitis Vinifera L)mentioning

confidence: 99%

An Evaluation of Traditional Persian Medicine for the Management of SARS-CoV-2

Bahramsoltani

Rahimi

2020

Front. Pharmacol.

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“…STAT3, SIRT-1, and PPAR have a protective involvement in DOX-induced myocardial hypertrophy by regulating the expression of the Atrial Natriuretic Factor, β-MHC, and cardiotrophin. [101][102][103] Similarly, the antagonist of ETA/endothelin B, bosentan (β-blocker) along with the inhibitor, angiotensin-converting enzyme exhibit a perseverance in myocardial contractility during DOX-induced cardiotoxicity. 104,105 Calpain, a cytosolic Ca 2+ regulated cysteine protease, is associated with myofibrillar deterioration, and works by instigating the degradation of contractile protein, titin and calpain inhibitors such as, MDL28170, and is effective in strengthening tcardiac contractility.…”

Section: Limiting the Detrimental Effect Of Dox On Contractile Machmentioning

confidence: 99%

“…DOX directly or indirectly can interfere with contractile machinery and interrupt cardiac normal functioning. STAT3, SIRT‐1, and PPAR have a protective involvement in DOX‐induced myocardial hypertrophy by regulating the expression of the Atrial Natriuretic Factor, β‐MHC, and cardiotrophin 101‐103 . Similarly, the antagonist of ETA/endothelin B, bosentan (β‐blocker) along with the inhibitor, angiotensin‐converting enzyme exhibit a perseverance in myocardial contractility during DOX‐induced cardiotoxicity 104,105 .…”

Section: Limiting the Detrimental Effect Of Dox On Contractile Machinerymentioning

confidence: 99%

A short review: Doxorubicin and its effect on cardiac proteins

Upadhyay

Gupta

Mantha

et al. 2020

J of Cellular Biochemistry

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Doxorubicin (DOX) is a boon for cancer‐suffering patients. However, the undesirable effect on health on vital organs, especially the heart, is a limiting factor, resulting in an increased number of patients with cardiac dysfunction. The present review focuses on the contractile machinery and associated factors, which get affected due to DOX toxicity in chemo‐patients for which they are kept under life‐long investigation for cardiac function. DOX‐induced oxidative stress disrupts the integrity of cardiac contractile muscle proteins that alter the rhythmic mechanism and oxygen consumption rate of the heart. DOX is an oxidant and it is further discussed that oxidative stress prompts the damage of contractile components and associated factors, which include Ca2+ load through Ca2+ ATPase, SERCA, ryanodine receptor‐2, phospholamban, and calsequestrin, which ultimately results in left ventricular ejection and dilation. Based on data and evidence, the associated proteins can be considered as clinical markers to develop medications for patients. Even with the advancement of various diagnosing tools and modified drugs to mitigate DOX‐induced cardiotoxicity, the risk could not be surmounted with survivors of cancer.

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“…e SIRT-1-mediated pathway and its downstream activator PPARS are important for the maintenance of cell function. Glycyrrhiza extract could restore nuclear SIRT-1 and PPAR-c levels in H9C2 cardiomyocytes reduced by DOX interference [75]. It is concluded that Gancao extract can antagonize the cardiotoxicity induced by DOX and maintain the normal function of cardiac myocytes.…”

Section: Herbsmentioning

confidence: 87%

Study on Medication Rules of Traditional Chinese Medicine against Antineoplastic Drug‐Induced Cardiotoxicity Based on Network Pharmacology and Data Mining

Dan

Liu

Guo

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background and Aim. Antineoplastic drug-induced cardiotoxicity (ADIC) becomes the second leading cause of death for tumor survivors after tumor recurrence and metastasis, and there may be great room for development in the future of traditional Chinese medicine (TCM). However, the theory of anticardiotoxicity of TCM has not yet formed a system. This study aimed to explore the material basis and the rule of TCM against ADIC based on network pharmacology and data mining. Methods. The targets of antineoplastic drugs with cardiotoxicity were obtained from the National Center for Biotechnology Information (NCBI) database, China national knowledge infrastructure (CNKI) database, and Swiss Target Prediction platform. Then, the cardiotoxicity-related targets were derived from the Gene Cards, Disgenet, OMIM, and DrugBank databases, as well as the drug of current clinical guidelines. The targets both in these two sets were regarded as potential targets to alleviate ADIC. Then, candidate compounds and herbs were matched via Traditional Chinese Medicine Systems Pharmacology (TCMSP) platform. Cytoscape3.7.1 was used to set up the target-compound-herb network. Molecular docking between core targets and compounds was performed with AutodockVina1.1.2. The rules of herbs were summarized by analyzing their property, flavor, and channel tropism. Results. Twenty-one potential targets, 332 candidate compounds, and 400 kinds of herbs were obtained. Five core targets including potassium voltage-gated channel subfamily H member 2 (KCNH2), cyclin-dependent kinase 1 (CDK1), matrix metalloproteinase 2 (MMP2), mitogen-activated protein kinase1 (MAPK1), and tumor protein p53 (TP53) and 29 core compounds (beta-sitosterol, quercetin, kaempferol, etc.) were collected. Five core herbs (Yanhusuo, Gouteng, Huangbai, Lianqiao, and Gancao) were identified. Also, the TCM against ADIC were mainly bitter and acrid in taste, warm in property, and distributed to the liver and lung meridians. Conclusion. TCM against ADIC has great potential. Our study provides a new method and ideas for clinical applications of integrated Chinese and western medicine in treating ADIC.

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Glycyrrhiza glabra (Licorice) root extract attenuates doxorubicin-induced cardiotoxicity via alleviating oxidative stress and stabilising the cardiac health in H9c2 cardiomyocytes

Cited by 65 publications

References 36 publications

An Evaluation of Traditional Persian Medicine for the Management of SARS-CoV-2

An Evaluation of Traditional Persian Medicine for the Management of SARS-CoV-2

A short review: Doxorubicin and its effect on cardiac proteins

Study on Medication Rules of Traditional Chinese Medicine against Antineoplastic Drug‐Induced Cardiotoxicity Based on Network Pharmacology and Data Mining

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