Glycyrrhizic acid derivatives as Dengue virus inhibitors

Baltina, L. A.; Tasi, Yan Ting; Huang, Su; Lai, Hsueh Chou; Балтина, Л. А.; Петрова, С. Ф.; Yunusov, M. S.; Lin, Cheng Wen

doi:10.1016/j.bmcl.2019.126645

Cited by 51 publications

(33 citation statements)

References 33 publications

(63 reference statements)

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“…Moreover, glycyrrhizin was bioactive against the varicella-zoster virus [ 60 ], herpex simplex virus [ 61 ], hepatitis C virus [ 62 ], and dengue virus [ 63 ]. The chemical structures of the compounds are shown in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

Bioactive Terpenes and Their Derivatives as Potential SARS-CoV-2 Proteases Inhibitors from Molecular Modeling Studies

Diniz¹,

Pérez-Castillo

Elshabrawy

et al. 2021

Biomolecules

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The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel coronavirus; the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Millions of cases and deaths to date have resulted in a global challenge for healthcare systems. COVID-19 has a high mortality rate, especially in elderly individuals with pre-existing chronic comorbidities. There are currently no effective therapeutic approaches for the prevention and treatment of COVID-19. Therefore, the identification of effective therapeutics is a necessity. Terpenes are the largest class of natural products that could serve as a source of new drugs or as prototypes for the development of effective pharmacotherapeutic agents. In the present study, we discuss the antiviral activity of these natural products and we perform simulations against the Mpro and PLpro enzymes of SARS-CoV-2. Our results strongly suggest the potential of these compounds against human coronaviruses, including SARS-CoV-2.

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Section: Resultsmentioning

confidence: 99%

Bioactive Terpenes and Their Derivatives as Potential SARS-CoV-2 Proteases Inhibitors from Molecular Modeling Studies

Diniz¹,

Pérez-Castillo

Elshabrawy

et al. 2021

Biomolecules

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“…The Val conjugate of monoterpenoids serves as plant defense potentiator Functional PSMs conjugated with L-amino acids have been explored academically for multiple pharmacological purposes, as represented by conjugates of menthol and borneol with glycine that exhibit analgesic and anti-in ammatory activities (Nesterkina and Kravchenko 2017), triterpenoids and asiatic acid conjugated with L-amino acids that exhibit antitumor activity (Ukiya et al 2010, Jing et al 2015, asiatic acid conjugated with L-amino acids, and glycyrrhizic acid conjugates with Ile (Dengue Virus inhibition) (Baltina et al 2019). Moreover, besides amino acids, β-pinene (monoterpenoid) derivatives containing amide moieties and acylthiourea moieties that exhibit in vitro antifungal activity have been developed (Shi et al 2019).…”

Section: Discussionmentioning

confidence: 99%

An amino acid ester of menthol elicits defense responses in plants

et al. 2021

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Terpenoids, including menthol, exhibit potent abilities as plant defense potentiators in agriculture and horticulture. In the current study, we developed new terpene derivatives that consisted of menthol and various amino acids and that were expected to act as powerful plant defense potentiators. We used 6 amino acids possessing low-reactive sidechains to synthesize an array of amino acid ester of menthol (ment-aa) compounds. Transcript levels of two defense genes (pathogenesis-related 1 [PR1] and trypsin inhibitor [TI]) were evaluated in leaves of soybean plants 24 h after application of aquatic solution of menthol or menthol-aa, and revealed that the menthol menthyl ester of valine (ment-Val) alone elevated the transcript level of defense genes, and it did so only at the low dose of 1 µM, not at higher or lower doses tested. Moreover, it appeared that histone acetylation was involved in this effect. Application of ment-Val enabled soybean plants to sustain the increased transcript levels in their leaves for up to 3 days. Moreover, when ment-Val was additionally applied at day 4, at which time the transcript level had declined to the basal level, the transcript level was re-elevated, indicating the possibility that ment-Val could be repeatedly used to sustain pest control. Ment-Val was found to be chemically stable and effective for defense of several crop species. Collectively, these data show that terpenoid conjugates are useful for pest control instead of or in addition to pesticides.

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“…Gycyrrhizin. Unknown Pompei et al, 1979 Pompei et al, 1980 Sato et al, 1996 Cinatl J et al, 2003 Hoever et al, 2005 Wolkerstorfer et al, 2009 Michaelis et al, 2011 Dao et al, 2010 Ashfaq et al, 2011 Hardy et al, 2012 Matsumoto et al, 2013 Yu et al, 2014 Laconi et al, 2014 Duan et al, 2015 Baltina et al, 2015 Chen Q et al, 2017 Si et al, 2018 Liang et al, 2019 Baltina et al, 2019 Gao et al, 2020 Tong et al, 2020 Chen and Du, 2020 …”

Section: Antiviral Effect Of Glycyrrhizin and Licorice Extractmentioning

confidence: 99%

“…The anti-SARS-CoV activity of glycyrrhizic acid (glycyrrhizin) was shown to be increased up to 70-fold by conjugation of glycyrrhizin with an amide or two amino acid residues, however, the cytotoxicity also increased resulting in a decrease in the selectivity index ( Hoever et al, 2005 ). Recently, it has been observed that glycyrrhizic acid derivatives were observed as Dengue virus inhibitors ( Baltina et al, 2019 ). More recently, Tong et al,(2020) observed that glycyrrhizic-Acid-Based Carbon Dots (Gly-CDs), semisynthetic derivatives of glycyrrhizic acid, possess multisite viral inhibition and unusual antiviral activity, providing a promising antiviral agent for the treatment of respiratory syndrome virus infection.…”

Section: Antiviral Effect Of Glycyrrhizin and Licorice Extractmentioning

confidence: 99%

The potential of glycyrrhizin and licorice extract in combating COVID-19 and associated conditions

Gomaa

Abdel-Wadood

2021

Phytomedicine Plus

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Background Several recent studies have stated that glycyrrhizin and licorice extract are present in most traditional Chinese medicine formulas used against SARS-CoV-2 in China. Significant data are showing that glycyrrhizin and licorice extract have multiple beneficial activities in combating most features of SARS-CoV-2 Purpose The aim of current review was to highlight recent progresses in research that showed the evidence of the potential use of glycyrrhizin and licorice extract against COVID-19. Methodology We have reviewed the information published from 1979 to October 2020. These studies demonstrated the effects , use and safety of glycyrrhizin and icorice extract against viral infections,bacterial infections, inflammatory disorders of lung ( in vitro and in vivo ). These studies were collated through online electronic databases research (Academic libraries as PubMed, Scopus, Web of Science and Egyptian Knowledge Bank). Results Pooled effect size of articles provides information about the rationale for using glycyrrhizin and licorice extract to treat COVID-19. Fifty studies demonstrate antiviral activity of glycyrrhizin and licorice extract. The most frequent mechanism of the antiviral activity is due to disrupting viral uptake into the host cells and disrupting the interaction between receptor- binding domain (RBD) of SARS-COV2 and ACE2 in recent articles. Fifty studies indicate that glycyrrhizin and licorice extract have significant antioxidant, anti-inflammatory and immunomodulatory effects. Twenty five studies provide evidence for the protective effect of glycyrrhizin and licorice extract against inflammation-induced acute lung injury and cardiovascular disorders. Conclusion The current study showed several evidence regarding the beneficial effects of glycyrrhizin and licorice extract in combating COVID-19. More randomized clinical trials are needed to obtain a precise conclusion.

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Glycyrrhizic acid derivatives as Dengue virus inhibitors

Cited by 51 publications

References 33 publications

Bioactive Terpenes and Their Derivatives as Potential SARS-CoV-2 Proteases Inhibitors from Molecular Modeling Studies

Bioactive Terpenes and Their Derivatives as Potential SARS-CoV-2 Proteases Inhibitors from Molecular Modeling Studies

An amino acid ester of menthol elicits defense responses in plants

The potential of glycyrrhizin and licorice extract in combating COVID-19 and associated conditions

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