Glycyrrhizin (20β-carboxy-11-oxo-30-norolean-12-en-3β-yl-2-O-β-d-glucopyranuronosyl-α-d-glucopyranosiduronic acid) improves the resistance of thermally injured mice to opportunistic infection of herpes simplex virus type 1

Utsunomiya, T.; Kobayashi, Makiko; Herndon, David N.; Pollard, Richard B.; Suzuki, Fujio

doi:10.1016/0165-2478(94)00183-r

Cited by 38 publications

(42 citation statements)

References 30 publications

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“…In previous studies from our laboratory, the impaired resistance of thermally injured mice to herpesvirus infection was recovered to levels observed in normal mice by glycyrrhizin (GR), an active component of licorice roots (9). Also, burn-associated impairment of interleukin-12 (IL-12) responsiveness was recovered in thermally injured mice treated with GR (10).…”

Section: Introductionmentioning

confidence: 92%

“…Also, burn-associated impairment of interleukin-12 (IL-12) responsiveness was recovered in thermally injured mice treated with GR (10). GR has been shown to be an inducer of type 2 antagonistic CD4 ϩ T cells (9,11,12), which have the ability to inhibit the production of IL-4 and IL-10 by burn-associated CD8 ϩ type 2 T cells (11,13). Type 2 antagonistic CD4 ϩ T cells induced by GR were characterized as CD4 ϩ CD28 ϩ TCR␣/␤ ϩ Vicia villosa lectin-adherent T cells (9,11,12).…”

Section: Introductionmentioning

confidence: 98%

“…Type 2 antagonistic CD4 ϩ T cells induced by GR were characterized as CD4 ϩ CD28 ϩ TCR␣/␤ ϩ Vicia villosa lectin-adherent T cells (9,11,12). They were different from the other CD4 ϩ T cell subsets, such as Th1 cells and Th2 cells, by their cytokine-producing profiles and adherence to V. villosa lectin (9,11,13). In addition, they showed no helper cell activity when they were subjected to the hemolysin production assay (13).…”

Section: Introductionmentioning

confidence: 98%

“…GR has been shown to be an inducer of type 2 antagonistic CD4 ϩ T cells (9,11,12), which have the ability to inhibit the production of IL-4 and IL-10 by burn-associated CD8 ϩ type 2 T cells (11,13). Type 2 antagonistic CD4 ϩ T cells induced by GR were characterized as CD4 ϩ CD28 ϩ TCR␣/␤ ϩ Vicia villosa lectin-adherent T cells (9,11,12). They were different from the other CD4 ϩ T cell subsets, such as Th1 cells and Th2 cells, by their cytokine-producing profiles and adherence to V. villosa lectin (9,11,13).…”

Section: Introductionmentioning

confidence: 99%

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Glycyrrhizin Improves the Resistance of MAIDS Mice to Opportunistic Infection of Candida albicans through the Modulation of MAIDS-Associated Type 2 T Cell Responses

Utsunomiya

Kobayashi²,

Ito

et al. 2000

Clinical Immunology

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Glycyrrhizin Improves the Resistance of MAIDS Mice to Opportunistic Infection of Candida albicans through the Modulation of MAIDS-Associated Type 2 T Cell Responses

Utsunomiya

Kobayashi²,

Ito

et al. 2000

Clinical Immunology

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“…GR has been used clinically in Japan for patients with active chronic hepatitis [9]. It has various biological activities including: induction of IFN-Á production [10], augmentation of NK cell activity [11], inhibition of inflammation [12] and suppression of herpesvirus replication [13]. In addition, GR is capable of inducing anti-type-2 T cells [14] and improving the resistance of hosts exposed to certain opportunistic pathogens [15].…”

Section: Introductionmentioning

confidence: 99%

Effect of Glycyrrhizin, an Active Component of Licorice Roots, on HIV Replication in Cultures of Peripheral Blood Mononuclear Cells from HIV-Seropositive Patients

et al. 2002

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The effect of glycyrrhizin (GR) on HIV replication in cultures of peripheral blood mononuclear cells (PBMC) from HIV-infected patients was investigated. After the depletion of CD8+ T cells, PBMC from HIV+ patients (patient PBMC) and PBMC from healthy donors (healthy PBMC) were cocultured in the presence or absence of GR (100 µg/ml) for 21 days. In cultures of 13 of 42 samples of patient PBMC (13/42, 31%), GR inhibited more than 90% of HIV replication. Among 42 samples of patient PBMC, 20 were identified to be infected with a non-syncytium-inducing variant of HIV (NSI-HIV), 15 with a syncytium-inducing variant of HIV (SI-HIV), and the remaining 7 were classified as cells infected with SI-HIV and/or NSI-HIV. GR inhibited more than 90% of HIV replication in cultures of 12 patient PBMC samples infected with NSI-HIV (12/20, 60%). In patient PBMC infected with SI-HIV, GR inhibited HIV replication in only 1 patient (1/15, 7%). In cultures of patient PBMC, GR induced the production of CC chemokine ligand (CCL)4 and CCL5 in a dose-dependent manner. When the assay was performed in PBMC cultures supplemented with a mixture of monoclonal antibodies for CCL4 and CCL5, no evidence of anti-HIV activity of GR was found. These results indicate that GR has the potential to inhibit NSI-HIV replication in patient PBMC cultures by inducing the production of β-chemokines.

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Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts

et al. 1997

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Survivors of allogeneic marrow transplants are immunodeficient for at least 1 year after grafting. Multiple defects of immunity have been found; however, it is not known which defect primarily accounts for the high infectious morbidity of these patients. Twenty-nine allograft recipients who were in complete remission of the original disease were examined for the following parameters of immunity at 1 year after transplant: infection score (gauging the number and severity of infections within the 6 months prior to the annual exam), serum total IgM, IgG, and IgA, anti-Haemophilus influenzae IgG, anti-Streptococcus pneumoniae IgG, skin test reactivity, and the blood counts of B cells, CD4 + T cells, CD8 + T cells, and their subsets. THe only parameter inversely correlated with the infection score was CD4 + T cell count (P = 0.005 in univariable analysis, P = 0.06 in multivariable analysis). We conclude that infectious morbidity of long-term transplant survivors is related to the reconstitution of CD4 + T cells. Am. J. Hematology 54:131-138, 1997 © 1997 Wiley-Liss, Inc.

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Glycyrrhizin (20β-carboxy-11-oxo-30-norolean-12-en-3β-yl-2-O-β-d-glucopyranuronosyl-α-d-glucopyranosiduronic acid) improves the resistance of thermally injured mice to opportunistic infection of herpes simplex virus type 1

Cited by 38 publications

References 30 publications

Glycyrrhizin Improves the Resistance of MAIDS Mice to Opportunistic Infection of Candida albicans through the Modulation of MAIDS-Associated Type 2 T Cell Responses

Glycyrrhizin Improves the Resistance of MAIDS Mice to Opportunistic Infection of Candida albicans through the Modulation of MAIDS-Associated Type 2 T Cell Responses

Effect of Glycyrrhizin, an Active Component of Licorice Roots, on HIV Replication in Cultures of Peripheral Blood Mononuclear Cells from HIV-Seropositive Patients

Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts

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