2022
DOI: 10.3389/fneur.2022.885020
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Glymphatic System Dysfunction: A Novel Mediator of Sleep Disorders and Headaches

Abstract: Sleep contributes to the maintenance of overall health and well-being. There are a growing number of patients who have headache disorders that are significantly affected by poor sleep. This is a paradoxical relationship, whereby sleep deprivation or excess sleep leads to a worsening of headaches, yet sleep onset also alleviates ongoing headache pain. Currently, the mechanism of action remains controversial and poorly understood. The glymphatic system is a newly discovered perivascular network that encompasses … Show more

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Cited by 23 publications
(26 citation statements)
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“…Aristotle came up with the brilliant idea that sleep triggers brain cleansing [ 22 ]. After 2000 years, his idea was confirmed by several studies suggesting that sleep activates unique brain processes for the removal of metabolites and wastes [ 15 , 23 , 24 , 25 , 26 , 27 , 28 ] ( Figure 1 ). However, not all sleep is crucial to CNS health.…”
Section: Therapeutic Properties Of Activation Of Brain Waste Removal ...mentioning
confidence: 88%
“…Aristotle came up with the brilliant idea that sleep triggers brain cleansing [ 22 ]. After 2000 years, his idea was confirmed by several studies suggesting that sleep activates unique brain processes for the removal of metabolites and wastes [ 15 , 23 , 24 , 25 , 26 , 27 , 28 ] ( Figure 1 ). However, not all sleep is crucial to CNS health.…”
Section: Therapeutic Properties Of Activation Of Brain Waste Removal ...mentioning
confidence: 88%
“…When the glymphatic system is damaged, it disrupts the brain's microenvironment, leading to an imbalance in the homeostasis of its internal environment, which inversely causes an increase in pro‐inflammatory substances in the brain, 23,24 resulting in headaches. Calcitonin gene‐related peptide (CGRP) is a neuropeptide that is widely distributed in the central and peripheral nervous system and can be present in three different locations upon release: the venous blood plasma, cerebrospinal fluid (CSF), and possibly the glymphatic system 7,25 . As an essential element of headaches, especially migraine, CGRP is a vasodilator and regulator of neuronal excitability 26 .…”
Section: Discussionmentioning
confidence: 99%
“…Most patients with headaches would gradually experience sleep problems 33 . Moreover, sleep disturbance can also lead to a decrease in substance exchange through the glymphatic system 7 . It is thought that awakening elicits the discharge of norepinephrine, resulting in the contraction of the interstitial space, which then inhibits substance exchange 23 .…”
Section: Discussionmentioning
confidence: 99%
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“…Sleep health is related to individual, social and contextual factors 18 . Increasing evidence demonstrates the association of sleep disorders with other comorbidities and indicates the crucial role of sleep deprivation and/or dysfunction in the development of these diseases 18 , 19 .…”
Section: The Approach To the Patient In Sleep Physiotherapymentioning
confidence: 99%