Glyoxylic Acid Monohydrate-Promoted Formation of the C–SO₂ Bond Starting from Maleimides/Quinones and Sodium Sulfinates

Abstract

By using glyoxylic acid monohydrate as a promoter, a wide range of substances containing a C–SO2 bond could be obtained from N-substituted maleimides or quinones and sodium sulfinates. The protocol features mild reaction conditions, short reaction time, and good atomic economics, which provides an alternative protocol for the α-sulfonylation of α,β-unsaturated ketones.