Glyphosate pathways to modern diseases V: Amino acid analogue of glycine in diverse proteins

Can glyphosate’s disruption of the gut microbiome and induction of sulfate deficiency explain the epidemic in gout and associated diseases in the industrialized world?

“…Three recent reviews of glyphosate have centred on the idea that glyphosate, acting as an amino acid analogue of glycine, may become incorporated into proteins in place of glycine through a coding error during protein synthesis [48][49][50]. The first study by Samsel and Seneff showed how disruption of multiple proteins in the body with highly conserved glycines could easily explain the correlations seen in the Swanson et al paper [48].…”

“…The first study by Samsel and Seneff showed how disruption of multiple proteins in the body with highly conserved glycines could easily explain the correlations seen in the Swanson et al paper [48]. The study by Seneff et al [49] focused specifically on ALS, and showed that a large number of proteins implicated in ALS have multiple glycine dependencies.…”

“…It receives an electron from each of four cytochrome c molecules, and transfers them to one oxygen molecule, converting it to two molecules of water. As described in [48], cytochrome c oxidase has an oxyanion hole that channels the oxygen molecule to the active site, and maintenance of this hole has a strong glycine dependency. Thus it is possible that impairments in glyphosate-contaminated cytochrome c oxidase lead to increased toxicity of sulfite in mitochondria.…”

“…They argue that this leads to functional iron deficiency and disrupted iron homeostasis, including elevated serum ferritin, which is linked to diabetes. Glyphosate exposure can be predicted to lead to both iron deficiency and iron toxicity (due to the Fenton reaction), because biological iron transport mechanisms are disrupted by glyphosate [48].…”

Glyphosate pathways to modern diseases VI: Prions, amyloidoses and autoimmune neurological diseases

“…In a recent paper [32], we suggested that glyphosate, a non-coding amino acid analogue of glycine, could substitute for glycine in error during protein synthesis. Such misincorporation and disruption of proteostasis could explain the strong correlations observed between glyphosate usage and multiple modern diseases.…”