2022
DOI: 10.3390/toxics10060321
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Glyphosate, Roundup and the Failures of Regulatory Assessment

Abstract: Roundup is the most widely used herbicide in agriculture. It contains glyphosate as the ‘active ingredient’, together with formulants. There are various versions of Roundup, with somewhat different effects depending on the formulants. Most genetically-modified crops are designed to tolerate Roundup, thus allowing spraying against weeds during the growing season of the crop without destroying it. Having been so heavily used, this herbicide is now found in the soil, water, air, and even in humans worldwide. Roun… Show more

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Cited by 30 publications
(9 citation statements)
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“…GLY, the most frequently used herbicide worldwide, is the focus of scientific and public discussions, especially in the European Union, where the renewing of its approval is approaching (currently approved in the EU until 15 December 2022). Recently, besides examining the acute and chronic biological effects (cytotoxicity, carcinogenicity, teratogenicity, endocrine disruption) of GLY 4 6 and some GBHs 52 , 53 , the focus has been on the occurrence of antibiotic resistance evoked by GLY in soil and bacterioplankton communities 54 , 55 , E. coli 56 , and Salmonella strains 26 , 57 . At the same time, other pathogenic bacteria like P. aeruginosa, with a high capacity to tolerate and utilize GLY as the sole P or N source leading to its complete degradation within 96h 40 , have not been investigated from the antibiotic resistance point of view 27 .…”
Section: Discussionmentioning
confidence: 99%
“…GLY, the most frequently used herbicide worldwide, is the focus of scientific and public discussions, especially in the European Union, where the renewing of its approval is approaching (currently approved in the EU until 15 December 2022). Recently, besides examining the acute and chronic biological effects (cytotoxicity, carcinogenicity, teratogenicity, endocrine disruption) of GLY 4 6 and some GBHs 52 , 53 , the focus has been on the occurrence of antibiotic resistance evoked by GLY in soil and bacterioplankton communities 54 , 55 , E. coli 56 , and Salmonella strains 26 , 57 . At the same time, other pathogenic bacteria like P. aeruginosa, with a high capacity to tolerate and utilize GLY as the sole P or N source leading to its complete degradation within 96h 40 , have not been investigated from the antibiotic resistance point of view 27 .…”
Section: Discussionmentioning
confidence: 99%
“…63−65 Close ties between regulatory agencies and the pesticide industry have been reported, including revolving doors, reliance on unpublished industry papers while dismissing papers published by independent scientists, and covert industry influence on the regulatory process. 66 Also, despite a clear legal requirement to disclose all performed studies, the pesticide industry withheld a substantial number [9 of 35 (26%)] of developmental neurotoxicity studies from EU authorities. If these studies had been submitted to the evaluating competent authorities, seven of the studies could have altered the outcome of the assessments.…”
Section: Conflict-of-interest-induced Bias and Manufacturing Of Doubt...mentioning
confidence: 99%
“…Another example is the widely used herbicide Roundup, which contains the active ingredient glyphosate along with formulation chemicals that may increase the toxicity of the product. Close ties between regulatory agencies and the pesticide industry have been reported, including revolving doors, reliance on unpublished industry papers while dismissing papers published by independent scientists, and covert industry influence on the regulatory process . Also, despite a clear legal requirement to disclose all performed studies, the pesticide industry withheld a substantial number [9 of 35 (26%)] of developmental neurotoxicity studies from EU authorities.…”
Section: Conflict-of-interest-induced Bias and Manufacturing Of Doubt...mentioning
confidence: 99%
“…For instance, the main surfactant used in RoundUp Optima+® used in this study is alkylpolyglycoside which consists of glucose and fatty alcohol, which could account for the shifts in metabolism reported here and elsewhere. What is clear, however, is that current policies on the listing and testing of all co-formulants in commercial formulations are inhibitory to achieving a full understanding of the effects and risks posed by the pesticidal AI and co-formulants alike on bees (Mullin, 2015;Mullin et al, 2015;Novotny, 2022;Straw et al, 2022).…”
Section: Glyphosate Alone Is Not Always Comparable To Glyphosate-base...mentioning
confidence: 99%
“…This represents a major knowledge gap in our attempts to mitigate the risks posed to pollinators by herbicides. Co-formulants are generally not subjected to the same testing rigour as the AI and where they have been tested, the focus has been on mortality, ignoring possible sublethal effects (Mesnage and Antoniou, 2018;Novotny, 2022;Straw et al, 2022). In addition, many co-formulants are considered proprietary information, making it difficult and sometimes impossible to assess co-formulant impact on the organism being studied (Mesnage and Antoniou, 2018).…”
Section: Introductionmentioning
confidence: 99%