Glyphosate: The world's most successful herbicide under intense scientific scrutiny

Duke, Stephen O.

doi:10.1002/ps.4902

Cited by 28 publications

(19 citation statements)

References 22 publications

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“…Their assessment classified glyphosate into Group E, not likely to be carcinogenic to humans. The Agrochemical Division of the American Chemical Society (ACS) dedicated an entire symposium to glyphosate during the 252nd Annual ACS Meeting in 2016, the presentations of which having been published recently (Duke, 2018). The 23 papers presented covered the history of glyphosate, plant glyphosate resistance management, its plant biology and societal issues, but not the toxicology of the compound, reflecting the favorable evaluation by the US EPA.…”

Section: Efsa Vs Iarcmentioning

confidence: 99%

Re-registration Challenges of Glyphosate in the European Union

Székacs

Darvas

2018

Front. Environ. Sci.

106

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Section: Efsa Vs Iarcmentioning

confidence: 99%

Re-registration Challenges of Glyphosate in the European Union

Székacs

Darvas

2018

Front. Environ. Sci.

106

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“…Until 2002, approximately 200 known species displayed single resistance or even cross‐resistance to herbicides of different chemical classes . This problem has intensified since the introduction of crops genetically modified to tolerate a narrow range of herbicides, which has encouraged over‐reliance of farmers on their routine and repeated use . Herbicide resistance is therefore, a growing threat to global food security (http://www.weedscience.org).…”

Section: Introductionmentioning

confidence: 99%

“…24 The compounds were prepared from rac-(3aR,4S,7R,7aS)-3a,4,7, 7a-tetrahydro−4,7-methanoisobenzofuran-1(3H)-one (7) and rac-(3aS,4S,7R,7aR)-3a,4,7,7a-tetrahydro-4,7-methanoisobenzofuran-1(3H)-one (8) (Fig. 2), that were synthesized via cycloaddition reaction between cyclopentadiene and furan-2(5H)-one (6). 25 The phytotoxic activities of compounds 7-8 and furan-2-(5H)-one were also evaluated.…”

Section: Introductionmentioning

confidence: 99%

Herbicidal activity of isobenzofuranones and in silico identification of their enzyme target

Teixeira

Alvarenga

Lopes

et al. 2019

Pest Management Science

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BACKGROUND Given the weed resistance to various herbicides with different mechanisms of action, the search for new compounds that are more effective and exhibit low levels of impact to other species in nature has been imperative in the field of the agriculture. For this purpose, 16 phthalides, and furan‐2(5H)‐one were synthetized and evaluated for their effectiveness as herbicides in seeds of Sorghum bicolor (sorghum), Cucumis sativus (cucumber), and Allium cepa (onion). Furthermore, a preliminary in silico study was carried out to identify the enzyme target of the most active compounds. RESULTS In the assays with S. bicolor, the mixture rac‐(3aR,4R,5S,6S,7S,7aS)‐5,6‐dibromohexahydro‐4,7‐methanoisobenzofuran‐1(3H)‐one + rac‐(3aR,4R,5R,6R,7S,7aS)‐5,6‐dibromohexahydro‐4,7‐methanoisobenzofuran‐1(3H)‐one (15a + 15b) showed comparable inhibitory activity to (S)‐metolachlor, which was used as control herbicide at concentrations ranging from 50 μm to 1000 μm. The developments of the seeds evaluated were altered by all 17 compounds, either stimulating or inhibiting. The best results were presented by compounds 15a, and 15b, either in their pure form or as a mixture. CONCLUSION The results presented by 15a, and 15b were superior to the activity of the commercial herbicide (S)‐metolachlor in the assays with C. sativus, and A. cepa. The in silico study provides strong evidence that the most active compounds bind to strigolactones esterases D14 through the same binding site of (5R)‐5‐hydroxy‐3‐methylfuran‐2(5H)‐one (H3M), which is one of the strigolactones (SLs) cleavage products. © 2019 Society of Chemical Industry

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“…Glyphosate is the most successful herbicide used for weed control in the world . In Brazil, it is the most used post‐emergent herbicide on eucalyptus plantations.…”

Section: Introductionmentioning

confidence: 99%

“…Glyphosate is the most successful herbicide used for weed control in the world. 1 In Brazil, it is the most used post-emergent herbicide on eucalyptus plantations. However, in areas with frequent applications of glyphosate, some weed species such as Conyza sp.…”

Section: Introductionmentioning

confidence: 99%