2006
DOI: 10.1016/j.humpath.2006.05.016
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Glypican-3 expression in hepatocellular tumors: diagnostic value for preneoplastic lesions and hepatocellular carcinomas

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Cited by 210 publications
(170 citation statements)
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“…Using this ELISA, we measured sGOLPH2 levels in the range of 1.5-60 g/mL with 5% of sera exceeding the upper range. The sGOLPH levels in this study are in the range of serum levels found for interleukin-2 (IL-2), IL-6, IL-8, tumor necrosis factor-␣, 11 CCSA-2 (colon cancer-specific antigen 2), 12 Glypican-3 in patients with HCC, 13 or C-reactive protein (CRP).…”
Section: Golph2 Protein Expression In Hepatocellularmentioning
confidence: 49%
“…Using this ELISA, we measured sGOLPH2 levels in the range of 1.5-60 g/mL with 5% of sera exceeding the upper range. The sGOLPH levels in this study are in the range of serum levels found for interleukin-2 (IL-2), IL-6, IL-8, tumor necrosis factor-␣, 11 CCSA-2 (colon cancer-specific antigen 2), 12 Glypican-3 in patients with HCC, 13 or C-reactive protein (CRP).…”
Section: Golph2 Protein Expression In Hepatocellularmentioning
confidence: 49%
“…[34][35][36][37][38][39] GPC3 immunoreactivity has a reported sensitivity of 77% and specificity of 96% in the diagnosis of small HCC; therefore, GPC3 positivity is a strong argument for malignancy. 40,41 The staining pattern is usually cytoplasmic but may be membranous or canalicular (Fig. 4).…”
Section: Emerging Tumor Markersmentioning
confidence: 99%
“…[18][19][20][21] In the current series, 10 cases of ␤-catenin-activated HCA without HCC were negative for GPC3 staining (data not shown). However, considering that only 64% of HCC developed on normal liver were previously shown to be positively stained by GPC3, 22 we need to identify new markers of malignant transformation of the ␤-catenin-activated adenomas and therefore precisely understand the malignant transformation of this type of HCA. Furthermore, we found that SAA overexpression in inflammatory adenomas included all cases of lesions previously classified as telangiectatic FNH.…”
Section: Discussionmentioning
confidence: 99%