Gm and Km PHENOTYPE FREQUENCIES IN CHILDREN WITH CHRONIC ACTIVE HEPATITIS (CAH) B VIRUS INFECTION

Kacprzak-Bergman, I; Hałasa, J

doi:10.1111/j.1744-313x.1994.tb00207.x

Cited by 3 publications

(2 citation statements)

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“…In our previous work (Kacprzak-Bergman & Halasa, 1994) in children affected with hepatitis B virus and manifesting chronic active hepatitis (CAH), the Gm (1, 2, 3, 10, 21) phenotype appeared to be more frequent than in both other HBV infected groups and in healthy children.…”

Section: Discussionmentioning

confidence: 87%

FREQUENCY OF Gm AND Km PHENOTYPES IN CHILDREN WITH MUMPS MENINGITIS

Kacprzak-Bergman

Haasa

1995

Int J Immunogenetics

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Section: Discussionmentioning

confidence: 87%

FREQUENCY OF Gm AND Km PHENOTYPES IN CHILDREN WITH MUMPS MENINGITIS

Kacprzak-Bergman

Haasa

1995

Int J Immunogenetics

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“…Results of these investigations thus suggest genetic mediation of the immune response t o inflammation in the nervous system. However, immunological reactions in the course of some viral infections could be dependent on other genetic factors as complement (C4) alleles (Rittner et al, 1989) and Gm alleles (Kacprzak- Bergman and Halasa, 1994). The purpose of this study was to estimate the contribution of genetic and environmental factors in the levels of antimeasles, anti-rubella, and anti-mumps antibodies in twins.…”

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confidence: 98%

Genetic estimation of the humoral responses to several infectious agents

Kacprzak-Bergman

1995

American J Hum Biol

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Heritabilities of antibody levels to measles, rubella, and mumps were estimated in 88 MZ and DZ twin pairs. The contribution of genetic factors in phenotypic antibody levels to measles was somewhat lower than environmental factors in both sexes (h = 0.450 and 0.459). A significantly stronger genetic than environmental control of anti-mumps antibody levels was evident in both sexes, but more so in females (h = 0.882) than in males (h = 0.626). The genetic determination of anti-rubella antibodies was also significantly higher in girls (h = 0.833), while environmental determination was greater in boys (h = 0.350). © 1995 Wiley-Liss, Inc.

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Epistatic Effects of Immunoglobulin GM and KM Allotypes on Outcome of Infection with Hepatitis C Virus

Pandey

Astemborski

Thomas

2004

J Virol

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Immunoglobulin GM and KM allotypes-genetic markers of ␥ and chains, respectively-are associated with immune responsiveness to several infectious pathogens and with survival in certain viral epidemics. We hypothesized that GM and KM allotypes affect the outcome of hepatitis C virus (HCV) infection. To test this hypothesis, we serologically allotyped 100 persons with well-documented clearance of HCV infection and 198 matched persistently infected persons. None of the GM or KM phenotypes by itself was associated with the clearance or persistence of HCV infection. Particular combinations of these phenotypes, however, were significantly associated with the outcome of HCV infection. Subjects with GM 1,17 5,13 and KM 1,3 phenotypes were over three times (odds ratio Hepatitis C virus (HCV) is a major health problem, affecting over 170 million people worldwide (47). Of persons acutely infected with HCV, about 15% spontaneously clear the virus. Among the factors influencing the outcome of HCV infection, the host genetic factors are thought to play a predominant role. Reports from several studies documenting consistent associations of particular HLA alleles with viral persistence and clearance support this contention (40,41,43). Allelic variation at the HLA loci, however, accounts for only a small percentage of the total interindividual variation in the outcome of HCV infection (41), suggesting involvement of additional genetic factors that might modify the host immune responsiveness to this pathogen.[Immunoglobulin (Ig) GM and KM allotypes-hereditary antigenic determinants of IgG heavy chains and -type light chains, respectively-are associated with viral immunological properties and thus are ideal candidate genetic systems for investigations to identify risk-conferring factors in HCV pathogenesis. GM and KM allotypes are associated with the susceptibility to and outcome of infection by several infectious agents (1-3, 6-13, 21, 23-26, 28-30, 33, 35). GM allotypes are strongly associated with IgG subclass concentrations (19,22,27,34), making them relevant to viral immunity, as the antibody responses to most viral epitopes appear to be IgG subclass (IgG1 and IgG3) restricted (15,37,39).These observations led us to hypothesize that GM and KM allotypes might contribute to the outcome of HCV infection through their possible influence on allotype-restricted antibody responses to the viral antigens. In addition, since particular GM and KM phenotypes have been shown to interact in influencing humoral immunity to certain viral epitopes (1), we wished to determine whether such epistatic interactions were associated with the outcome of HCV infection. MATERIALS AND METHODSStudy population. Between 1988 and 1989, a cohort was recruited in Baltimore, Md., of persons who had injected illicit drugs in the preceding 10 years, were more than 17 years of age, and were free of manifestations of AIDS (44). Within this cohort, a subset of 1,667 individuals was identified as the HCV subcohort because they had antibodies to HCV and had made at le...

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Gm and Km PHENOTYPE FREQUENCIES IN CHILDREN WITH CHRONIC ACTIVE HEPATITIS (CAH) B VIRUS INFECTION

Cited by 3 publications

References 12 publications

FREQUENCY OF Gm AND Km PHENOTYPES IN CHILDREN WITH MUMPS MENINGITIS

FREQUENCY OF Gm AND Km PHENOTYPES IN CHILDREN WITH MUMPS MENINGITIS

Genetic estimation of the humoral responses to several infectious agents

Epistatic Effects of Immunoglobulin GM and KM Allotypes on Outcome of Infection with Hepatitis C Virus

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