GM Crops for Plant Virus Resistance: A Review

Johnson, A. M. Anthony; Gopal, D. V. R. Sai; Sudhakar, Chinta

doi:10.1007/978-981-15-5932-7_11

Cited by 5 publications

(6 citation statements)

References 467 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The transgenic plants expressing the coat protein (CP) gene of TMV were shown to exhibit a resistance against infection [67]. This ground-breaking discovery initiated the development of various virus-resistant transgenic plants [6]. PDR can be classified into different types depending on the strategy used to generate the resistance towards the virus in the host plant.…”

Section: Pathogen-derived Resistancementioning

confidence: 99%

“…This process entails the expression of viral-encoded proteins like CP, MP (movement protein) or Rep (replicase) in plants to counteract viruses [6]. In 1986, Beachy's group first demonstrated that the expression of the CP gene of TMV in transgenic tobacco plants could provide considerable protection against viral infection [68].…”

Section: Protein-mediated Resistancementioning

confidence: 99%

“…In 1986, Beachy's group first demonstrated that the expression of the CP gene of TMV in transgenic tobacco plants could provide considerable protection against viral infection [68]. It was observed that the expression of these viral proteins interfered with the disassembly of the virus by the formation of pseudo-capsids [6]. Several transgenics were made using the CP of the Cucumber mosaic virus (CMV), Papaya ringspot virus (PRSV), PVX, Plum pox virus (PPV), Zucchini yellow mosaic virus (ZYMV), Watermelon mosaic virus (WMV), Tomato yellow leaf curl virus (TYLCV), Tomato mosaic virus (ToMV), and so on [69].…”

Section: Protein-mediated Resistancementioning

confidence: 99%

“…Viruses are responsible for a worldwide crop loss of $30 billion annually and is predicted to reach up to $60-80 billion [3][4][5]. Plant viral diseases threaten global food security as they can cause severe food limitations for the world population, which is projected to elevate from 8 billion in 2022 to 10 billion by 2050 [6,7].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

When an Intruder Comes Home: GM and GE Strategies to Combat Virus Infection in Plants

Rahman,

Sanan-Mishra

2024

Agriculture

View full text Add to dashboard Cite

Viruses are silent enemies that intrude and take control of the plant cell’s machinery for their own multiplication. Infection by viruses and the resulting damage is still a major challenge in the agriculture sector. Plants have the capability to fight back, but the ability of viruses to mutate at a fast rate helps them to evade the host’s response. Therefore, classical approaches for introgressing resistance genes by breeding have obtained limited success in counteracting the virus menace. Genetic modification (GM)-based strategies have been successful in engineering artificial resistance in plants. Several different approaches based on pathogen-derived resistance, antisense constructs, hairpin RNAs, double-stranded RNA, etc., have been used to enhance plants’ resistance to viruses. Recently, genome editing (GE) strategies mainly involving the CRISPR/Cas-mediated modifications are being used for virus control. In this review, we discuss the developments and advancements in GM- and GE-based methods for tackling viral infection in plants.

show abstract

Section: Pathogen-derived Resistancementioning

confidence: 99%

Section: Protein-mediated Resistancementioning

confidence: 99%

Section: Protein-mediated Resistancementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

When an Intruder Comes Home: GM and GE Strategies to Combat Virus Infection in Plants

Rahman,

Sanan-Mishra

2024

Agriculture

View full text Add to dashboard Cite

show abstract

“…Interestingly, antagonistic interactions of strains were applied for plant ‘vaccination’ purposes when plants infected by a mild viral strain were protected from infection with an aggressive one, a phenomenon called ‘cross-protection’ [ 11 , 12 , 13 ]. Based on a similar principle, genetically modified crops expressing viral capsid proteins were developed to introduce resistance to related viruses [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Transmission of Diverse Variants of Strawberry Viruses Is Governed by a Vector Species

Koloniuk

Matyášová

Brázdová

et al. 2022

Viruses

View full text Add to dashboard Cite

Advances in high-throughput sequencing methods have boosted the discovery of multistrain viral infections in diverse plant systems. This phenomenon appears to be pervasive for certain viral species. However, our knowledge of the transmission aspects leading to the establishment of such mixed infections is limited. Recently, we reported a mixed infection of a single strawberry plant with strawberry mottle virus (SMoV), strawberry crinkle virus (SCV) and strawberry virus 1 (StrV-1). While SCV and StrV-1 are represented by two and three molecular variants, respectively, SmoV has three different RNA1 and RNA2 segments. In this study, we focus on virus acquisition by individual adult aphids of the Aphis gossypii, Aphis forbesi and Chaetosiphon fragaefolii species. Single-aphid transmission trials are performed under experimental conditions. Both different viruses and individual virus strains show varying performances in single aphid acquisition. The obtained data suggests that numerous individual transmission events lead to the establishment of multistrain infections. These data will be important for the development of epidemiological models in plant virology.

show abstract

Viral Nanoparticles‐Mediated Delivery of Therapeutic Cargo

Zanganeh

Doroudian

Nowzari

et al. 2023

Advanced Therapeutics

View full text Add to dashboard Cite

The rapid advancement of nanotechnology in recent years has opened new avenues of investigation for biomedical sciences. Viral nanoparticles (VNPs) are formulated from plant viruses, mammalian viruses, or bacteriophages. Based on their structure, viruses, and synthetic carriers have been utilized to design bio‐inspired nanocarriers, which serve as building blocks for innovative therapeutic applications. Scientists can chemically or genetically engineer VNPs to encompass various properties, such as enhancing their functionalization with therapeutic molecules and imaging reagents, enabling targeted delivery to specific ligands. The implementation of these novel nanocarrier platforms can revolutionize treatments for cancer, infectious diseases, and chronic illnesses. The primary goal of drug delivery systems is to localize cargo to the specific target site, increasing therapeutic benefits and minimizing off‐target effects. This review critically evaluates the major virus species used as nanocarriers, their applications in therapeutics, and their advantages and disadvantages.

show abstract

GM Crops for Plant Virus Resistance: A Review

Cited by 5 publications

References 467 publications

When an Intruder Comes Home: GM and GE Strategies to Combat Virus Infection in Plants

When an Intruder Comes Home: GM and GE Strategies to Combat Virus Infection in Plants

Transmission of Diverse Variants of Strawberry Viruses Is Governed by a Vector Species

Viral Nanoparticles‐Mediated Delivery of Therapeutic Cargo

Contact Info

Product

Resources

About