GM-CSF and G-CSF stimulate the synthesis of histamine and putrescine in the hematopoietic organs in vivo

Endo, Yasuo; Kikuchi, Takashi; Takeda, Yoshikazu; Nitta, Yoshio; Rikiishi, Hidemi; Kumagai, Katsuo

doi:10.1016/0165-2478(92)90086-4

Cited by 63 publications

(65 citation statements)

References 17 publications

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“…Moreover, haematopoietic cytokines, such as interleukin-3 (IL-3), granulocyte-macrophage-colony stimulating factor (GM-CSF) and granulocyte-colony stimulating factor (G-CSF), induced HDC in vivo only in haematopoietic organs (Lebel et al, 1990;Endo et al, 1992b). These, and our recent results (Endo et al, 1995), suggest that histamine is involved in haematopoiesis, probably with a role in the formation of macrophages and granulocytes.…”

Section: Introductionmentioning

confidence: 82%

“…Substances with adjuvant activity such as lipopolysaccarides and SEPS can also increase HDC activity in the bone marrow and spleen (Endo et al, 1992b;Ando et al, 1984). Freund's complete adjuvant also increases HDC activity in these organs (data not shown).…”

Section: Discussionmentioning

confidence: 99%

“…However, non-aminoBPs showed no such activity. Compared to the transient enhancement of HDC activity after the injection of lipopolysaccharides (LPS) or cytokines (Endo, 1989;Endo et al, 1992b), the enhancement of HDC activity by the aminoBPs was remarkably long-lasting, persisting for several days (Endo et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

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Contrast between effects of aminobisphosphonates and non‐aminobisphosphonates on collagen‐induced arthritis in mice

Nakamura

Ando

Abe

et al. 1996

British J Pharmacology

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1 Bisphosphonates (BPs) are inhibitors of bone resorption, and many derivatives have been developed for the treatment of enhanced bone resorption. Aminobisphosphonates (aminoBPs) are particularly potent in this respect. We have shown previously that aminoBPs, such as 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (AHBuBP), induce histidine decarboxylase, the enzyme forming histamine, and increase macrophages, granulocytes and osteoclast numbers. Non-aminoBPs do not show this activity. 2 In the present study, an additional aminoBP, cycloheptyl-aminomethylene bisphosphonate (CHAMBP), was shown to have similar properties to AHBuBP suggesting that these actions are common among aminoBPs. 3 In experiments carried out to determine if aminoBPs affect immune responses, we found that CHAMBP and AHBuBP each exacerbated the arthritis induced in mice by the co-injection of type II collagen and an adjuvant, a model for rheumatoid arthritis. In contrast, dichloromethylene bisphosphonate (C12MBP), a typical non-aminoBP, did suppress the arthritis. 4 On the basis of these results, and those obtained previously, we propose that the exacerbating effects of CHAMBP and AHBuBP may be related to their ability to stimulate the synthesis of histamine and to increase macrophages and granulocytes. Conversely, we propose that the suppressive effect of C12MBP on arthritis is related to its cytotoxic action on macrophages or granulocytes.

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Section: Introductionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

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Contrast between effects of aminobisphosphonates and non‐aminobisphosphonates on collagen‐induced arthritis in mice

Nakamura

Ando

Abe

et al. 1996

British J Pharmacology

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“…It has been demonstrated that the activity of ornithine decarboxylase (ODC), the rate-limiting enzyme of the polyamine cascade, is regulated by intracellular polyamine concentrations in various ways, namely inhibition of translation, acceleration of ODC degradation and induction of an ODC-inhibitory protein named antizyme [24,25]. Knowing that both polyamines and histamine may play an important role during cell proliferation and/or differentiation, and that their synthesis by ODC and HDC respectively, is induced in hematopoietic organs by the same growth factors [7,[26][27][28], we are actually investigating whether similar mechanisms regulate HDC and ODC activities.…”

Section: S Corbel M Dy/febs Letters 391 (1996) 279-281mentioning

confidence: 99%

Evidence for bidirectional histamine transport by murine hematopoietic progenitor cells

Corbel

1996

FEBS Letters

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Murine hematopoietic progenitor cells synthesize substantial amounts of histamine in response to IL-3 or calcium ionophore. They also take up extracellular histamine by an active transport system. In the present study we demonstrate that this system mediates both influx and efflux of histamine. Indeed, MR16155 and thioperamide, the two 1-13 antagonists which are most effective in inhibiting histamine uptake, likewise diminish the release of preloaded histamine from bone marrow cells. These compounds also inhibit the release of histamine which has been newly synthesized by hematopoietic progenitors in response to IL-3 or calcium ionophore, as assessed by the accumulation of the mediator inside the cells in the presence of the antagonists. The potency of different histamine receptor antagonists as inhihitors of histamine release increases with their capacity to block histamine uptake.Key words: Hematopoietic progenitor; Histamine; Bidirectional transport; Interleukin-3 Histamine uptake is temperature-dependent and partially requires sodium exchange [13]. Although we have provided evidence that this phenomenon is not mediated by classical histamine receptors, Ha receptor antagonists, such as thioperamide and MR16155, are potent inhibitors. Conversely to the polyamine transport system, which exists in numerous cell types and has been extensively studied [14,15], histamine transport seems to be restricted to astrocytes, endothelial and glial cells, and is still poorly understood [16][17][18]. It has been suggested that astrocytes could use the same means of transport for histamine uptake and release [18]. Herein, we provide evidence for a bidirectional transporter in bone marrow cells (BMC) and in the IL-3-dependent cell line FDCP1, as assessed by the finding that the inhibitors of histamine uptake likewise decrease release of preloaded histamine. We also show that this system is involved in the release of endogenous histamine which is newly synthesized in response to IL-3 or calcium ionophore since we found a decrease in histamine release accompanied by an increase in intracellular histamine contents in the presence of H3 receptor antagonists.

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“…[1][2][3] Histidine decarboxylase (HDC) is the histamine-forming enzyme. HDC activity is induced in response to a variety of stimuli, [4][5][6][7] and the induction of HDC activity is due to a de novo formation of HDC. 8) Recent studies suggest that histamine may play important physiological roles in skeletal muscles.…”

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confidence: 99%

Induction of the Histamine-Forming Enzyme Histidine Decarboxylase in Skeletal Muscles by Prolonged Muscular Work: Histological Demonstration and Mediation by Cytokines

Ayada

Tsuchiya

Yoneda

et al. 2017

Biological & Pharmaceutical Bulletin

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Recent studies suggest that histamine-a regulator of the microcirculation-may play important roles in exercise. We have shown that the histamine-forming enzyme histidine decarboxylase (HDC) is induced in skeletal muscles by prolonged muscular work (PMW). However, histological analysis of such HDC induction is lacking due to appropriate anti-HDC antibodies being unavailable. We also showed that the inflammatory cytokines interleukin (IL)-1 and tumor necrosis factor (TNF)-α can induce HDC, and that PMW increases both IL-1α and IL-1β in skeletal muscles. Here, we examined the effects (a) of PMW on the histological evidence of HDC induction and (b) of IL-1β and TNF-α on HDC activity in skeletal muscles. By immunostaining using a recently introduced commercial polyclonal anti-HDC antibody, we found that cells in the endomysium and around blood vessels, and also some muscle fibers themselves, became HDC-positive after PMW. After PMW, TNF-α, but not IL-1α or IL-1β, was detected in the blood serum. The minimum intravenous dose of IL-1β that would induce HDC activity was about 1/10 that of TNF-α, while in combination they synergistically augmented HDC activity. These results suggest that PMW induces HDC in skeletal muscles, including cells in the endomysium and around blood vessels, and also some muscle fibers themselves, and that IL-1β and TNF-α may cooperatively mediate this induction.

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GM-CSF and G-CSF stimulate the synthesis of histamine and putrescine in the hematopoietic organs in vivo

Cited by 63 publications

References 17 publications

Contrast between effects of aminobisphosphonates and non‐aminobisphosphonates on collagen‐induced arthritis in mice

Contrast between effects of aminobisphosphonates and non‐aminobisphosphonates on collagen‐induced arthritis in mice

Evidence for bidirectional histamine transport by murine hematopoietic progenitor cells

Induction of the Histamine-Forming Enzyme Histidine Decarboxylase in Skeletal Muscles by Prolonged Muscular Work: Histological Demonstration and Mediation by Cytokines

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