1993
DOI: 10.1006/clin.1993.1068
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GM3 as a Target of Anti-lymphocytic Ganglioside Antibodies in AIDS Patients

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Cited by 25 publications
(19 citation statements)
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“…This finding is in agreement with previous reports on both total cell extract (1,2,41) and low density Triton-insoluble fraction (4). Here, we further characterized the GM3 comigrating band as GM3 by MS and GLC.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…This finding is in agreement with previous reports on both total cell extract (1,2,41) and low density Triton-insoluble fraction (4). Here, we further characterized the GM3 comigrating band as GM3 by MS and GLC.…”
Section: Discussionsupporting
confidence: 93%
“…In human peripheral blood lymphocytes (PBL) 1 monosialoganglioside GM3 represents the main ganglioside constituent of cell plasma membrane (72% of total ganglioside content) (1), although not correlated with a particular lymphocyte subpopulation, i.e. both CD4 ϩ and CD8 ϩ cells express a similar amount of GM3 (2). Minor ganglioside constituents of human PBL include sialosyl paragloboside (about 14%) and sialosyl lactohexaosyl ceramide (about 7%) (1).…”
mentioning
confidence: 99%
“…Moreover, we recently reported a 4-fold increase of GM3 concentration at the surface of HIV-infected lymphocytes, which appears to be consistent with the increase of GM3 concentration observed in human normal lymphocytes after incorporation of exogenous GM3 (22). These results suggest that GM3 may play a role in the CD4 down-modulation occurring during HIV infection (52,53). It is noteworthy that gangliosides modulate a number of immune functions (54) and the down-regulation of CD4 expression may be essential for normal T responses.…”
Section: Figsupporting
confidence: 87%
“…For the biopanning, purified human MHC class II antigen, type DR1, was kindly provided by L. Teyton (The Scripps Research Institute, La Jolla, CA). Elevated levels of anti-ganglioside antibodies have been reported associated with neuropathy (33) and AIDS (34) and increased levels of gangliosides have been found on lymphocytes from AIDS patients. The sialic acidcontaining glycosphingolipid GD2 used for biopanning was obtained from Sigma.…”
mentioning
confidence: 99%