Gnathic osteoblastoma: Clinicopathologic review of seven cases with long-term follow-up

Clinical–Pathological Conference: Case 4

“…While no discomfort was reported in the present case, recent literature indicates that significantly fewer patients experience pain associated with this neoplasm than was previously suggested [1]. The radiographic features of osteoblastoma can vary from a well-demarcated to illdefined osteolytic lesion with variable internal structure that can range from entirely radiolucent to our finding of a central radiopacity with radiolucent periphery [1][2][3].…”

“…Osteoblastoma is a rare primary bone tumor that typically occurs in patients under the age of 30, with a slight female predominance and a predilection for the mandible, particularly the posterior segments [1,2]. Pain and swelling with bone expansion are common clinical features [1,3]. While no discomfort was reported in the present case, recent literature indicates that significantly fewer patients experience pain associated with this neoplasm than was previously suggested [1].…”

“…Additionally, in contrast to the basophilic trabeculae often seen in osteoblastoma, cementoblastoma is characterized by sheets of eosinophilic mineralized tissue resembling cellular cementum containing plump cells within irregular lacunae [3,9,10]. The current diagnosis was supported by the identification of these features, in addition to focal encapsulation and the presence of the classic histopathologic pattern of peripheral radiating trabeculae [9,10].…”

Case Report: a Pediatric Case of Cementoblastoma with Histologic and Radiographic Features of an Osteoblastoma and Osteosarcoma

“…No clear gender predilection is seen with a peak in the second to third decade of life [4,5]. In the jaws, they often affect the mandible and present with painful swelling [6]. Radiographically, they begin as a well-circumscribed radiolucency progressing to a mixed lesion; at times they are associated with expansion of the cortical bone [7].…”

“…Radiographically, they begin as a well-circumscribed radiolucency progressing to a mixed lesion; at times they are associated with expansion of the cortical bone [7]. Histologically, the appearance can be variable with bony trabeculae in a loose fibrovascular stroma, plasmacytoid to large epithelioid osteoblasts with vesicular nuclei containing eosinophillic cytoplasm, prominent osteoid production with osteoblastic rimming, and minimal mitotic activity [4,6]. At times, atypical cells that are large, multinucleate, with unusual degenerative nuclear features, and prominent nucleoli can be seen [8,9]; thus, differentiating this lesion from OS can be difficult.…”