The most prevalent malignant tumor in the oral cavity is squamous cell carcinoma (SCC). Social interactions are impeded, including eating, conversing, and practicing basic oral hygiene. A 43-year-old man who had previously suffered pus discharge in the right side of the buccal mucosa complained of dull aching in the lower right back of his jaw. The patient's right buccal mucosa was surgically treated for SCC two years ago. He received 30 cycles of high-dose radiation therapy for SCC of the right buccal mucosa. The right maxilla and mandible had osteoradionecrosis, according to a clinical and radiographic assessment. The aim of emphasizing the importance of cardiac rehabilitation and mouth opening exercises in oral squamous cell carcinoma (OSCC) is to address the multifaceted impact of this type of cancer on a patient's overall health and well-being. OSCC refers to a type of cancer that occurs in the cells lining the oral cavity, including the lips, tongue, gums, and the floor of the mouth. The implications of OSCC go beyond the local effects on the oral region and can have systemic consequences, affecting various aspects of a patient's health.