Goblet cell carcinoid of the appendix

Goblet Cell Carcinoid of the Appendix.

“…The cell origin of goblet cell carcinoid has been a controversial matter. To date, six main theories have been proposed to explain the histogenesis of goblet cell carcinoid: 1) an origin in the amine precursor uptake and decarboxylation cell (APUD) system (1 3), 2) two independent cell origins for mucin-producing cells and carcinoid cells (1,9,16) The clinical behavior of these tumors is variable and has led to somedisagreement in the literature regarding their malignant potential and their appropriate treatment. Earlier authors (6,7) felt that these tumors were prognostically equivalent to carcinoids and recommendedonly appendectomy as adequate treatment, but more recently the aggressive clinical behavior of these tumors has been recognized (5,(23)(24)(25).…”

“…Since the first report of carcinoid tumors of the appendix in 1838 by Merling, as noted by Rodriguez et al (1), multiple histologic types have been described. Although it has long been appreciated that mucin production mayoccur in carcinoids, the excessive production of mucin traditionally resulted in such tumors being classified as adenocarcinomas (2).…”

“…These terms reflect the continuing difference of opinion as to the cell of origin of these tumors. The clinical presentation of this neoplasm is variable, but appendicitis is very common (1,2,5,8,9,(12)(13)(14)(15)(16)(17) Goblet Cell Carcinoid of the Appendix probable periappendiceal abscess, a laparotomy was performed for a diagnosis of acute appendicitis. At laparotomy, the distal portion of the appendix was found to be adhered to the retroperitoneum with periappendiceal abscess formation.…”

Carcinoid Tumor of the Cystic Duct

“…Of additional importance, the NE tumors may occur as a collision tumor concomitantly with a non-NE tumor; may form a significant or integral component of non-NE tumors (mixed/composite glandular endocrine cell carcinoma) or may appear as amphicrine tumors, in which individual tumor cells exhibit endocrine-exocrine characteristics [13, 14, 15, 16, 17, 18, 19, 20]. …”

Cytology of Gastrointestinal Histoplasmosis

“…2,4,11 Signet ring cell carcinoid, a composite tumor exhibiting both adenocarcinomatous and carcinoid differentiation, has been found in the gastrointestinal tract, especially the appendix. 17,19 The cells are round to polygonal, with clear cytoplasm, small nuclei with finely granular chromatin, and rare mitoses. They stain with mucicarmine, PAS stain and chromogranin and have neurosecretory granules demonstrable on electron microscopy.…”