Goblet cell tumors of the appendix: A review

Sinno, Sara; Jurdi, Nawaf

doi:10.1016/j.anndiagpath.2019.151401

Cited by 12 publications

(7 citation statements)

References 19 publications

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“…Appendiceal goblet cell carcinoid (GCC) is a histological type with characteristic goblet cells mixed with neuroendocrine tumors [ 18 , 19 ]. In this study, a total number of 1087 (12.5%) of GCC patients were identified.…”

Section: Discussionmentioning

confidence: 99%

Chemotherapy in the treatment of different histological types of appendiceal cancers: a SEER based study

Wang

Chen

2021

BMC Cancer

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Background Due to its rarity and high heterogeneity, neither established guidelines nor prospective data are currently available for using chemotherapy in the treatment of appendiceal cancer. This study was to determine the use of chemotherapy and its potential associations with survival in patients with different histological types of the cancer. Methods Patients with histologically different appendiceal cancers diagnosed during 1998–2016 were selected from the Surveillance, Epidemiology, and End Results (SEER) database. The role and effect of chemotherapy were examined in the treatment of the disease. The Kaplan-Meier method was applied to construct survival curves and significance was examined by Log-rank test. Cox proportional hazard models were used to analyze the impact of chemotherapy and other variables on survival in these patients. Results A total of 8733 appendiceal cancer patients were identified from the database. Chemotherapy was administrated at highly variable rates in different histological types of appendiceal cancer. As high as 64.0% signet ring cell carcinoma (SRCC), 46.4% of mucinous adenocarcinomas (MAC), 40.6% of non-mucinous adenocarcinoma (NMAC) and 43.9% of mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) were treated with chemotherapy, whereas only 14.7% of goblet cell carcinoma (GCC), 5% neuroendocrine tumors (NETs) and 1.6% carcinomas (NEC) received chemotherapy. In all patients combined, chemotherapy significantly improved overall survival during the entire study period and cancer-specific survival was improved during in cases from 2012–2016. Further multivariate analysis showed that both cancer-specific and overall survival was significantly improved with chemotherapy in patients with MAC, NMAC and SRCC, but not for patients with GCC, MiNENs, NETs and NECs. Number (> 12) of lymph node sampled was associated with survival of patients with most histological types of cancer under study. Other prognostic factors related to individual histological types were identified. Conclusions Chemotherapy is administrated at highly variable rates in different histological types of appendiceal cancer. Efficacy of chemotherapy in the treatment of these cancers has been improved in recent years and is significantly associated with better survival for patients with NMAC, MAC, and SRCC. Adequate lymph node sampling may result in a survival benefit for most of these patients.

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Section: Discussionmentioning

confidence: 99%

Chemotherapy in the treatment of different histological types of appendiceal cancers: a SEER based study

Wang

Chen

2021

BMC Cancer

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“…Intercrypt goblet cells located on the luminal surface of the colon are associated with several intestinal diseases, and mice deficient in these cells have increased susceptibility to chemically induced colitis and spontaneous colitis with age ( Nyström et al, 2021 ). Although goblet cells regulate interactions between the gut and microbes, they can become cancerous ( Sinno and Jurdi, 2019 ).…”

Section: Hippo Pathwaymentioning

confidence: 99%

Hippo pathway in intestinal diseases: focusing on ferroptosis

Deng,

Jia,

Ming

et al. 2023

Front. Cell Dev. Biol.

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The incidence of intestinal diseases, such as inflammatory bowel disease, gastric cancer, and colorectal cancer, has steadily increased over the past decades. The Hippo pathway is involved in cell proliferation, tissue and organ damage, energy metabolism, tumor formation, and other physiologic processes. Ferroptosis is a form of programmed cell death characterized by the accumulation of iron and lipid peroxides. The Hippo pathway and ferroptosis are associated with various intestinal diseases; however, the crosstalk between them is unclear. This review elaborates on the current research on the Hippo pathway and ferroptosis in the context of intestinal diseases. We summarized the connection between the Hippo pathway and ferroptosis to elucidate the underlying mechanism by which these pathways influence intestinal diseases. We speculate that a mutual regulatory mechanism exists between the Hippo pathway and ferroptosis and these two pathways interact in several ways to regulate intestinal diseases.

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“…Among appendiceal tumours, a distinctive rare entity is represented by goblet cell adenocarcinoma ( ex‐goblet cell appendiceal carcinoid ), in which both neuroendocrine and mucinous differentiation are present 1 . Appendiceal ex‐goblet cell appendiceal carcinoid exhibits a more aggressive behaviour compared to usual typical carcinoid tumours, since more than 40%‐50% of cases present with metastases at the clinical outset 2,3 …”

Section: Morphology Quizmentioning

confidence: 99%

Unusual case of pleural effusion in a young woman

et al. 2020

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Dedicated to teaching and education for all staff working in cytology laboratories worldwide Unusual case of pleural effusion in a young woman 1 | C A S E HIS TORY • A 16-year-old girl was admitted to the emergency department with acute bilateral pleural effusion and bibasal lung hypophonesis. An overlapping mutational profile of goblet cell carcinoids and adenocarcinoma ex goblet cell carcinoids has been reported; the poor response to chemotherapy may be related to the low frequency of mutations, such as APC, KRAS, BRAF and TP53, largely appreciable in colorectal carcinomas. Therefore, in this pathological scenario, molecular updates are needed to choose targeted chemotherapy.

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Goblet cell tumors of the appendix: A review

Cited by 12 publications

References 19 publications

Chemotherapy in the treatment of different histological types of appendiceal cancers: a SEER based study

Chemotherapy in the treatment of different histological types of appendiceal cancers: a SEER based study

Hippo pathway in intestinal diseases: focusing on ferroptosis

Unusual case of pleural effusion in a young woman

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