“God has sent me to you”: Right temporal epilepsy, left prefrontal psychosis

Arzy, Shahar; Schurr, Roey

doi:10.1016/j.yebeh.2016.04.022

Cited by 14 publications

(7 citation statements)

References 35 publications

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“…For example, people with basal ganglia or caudate lesions can present with both hallucinations and delusions 60 , 61 . Furthermore, a case study of religious delusions in a patient with temporal lobe epilepsy was associated with overactivity of the PFC 62 , and there are multiple lines of evidence suggesting that the PFC is integral for delusionary beliefs 63 . Therefore, while impairing networks specific to certain sensory modalities can lead to hallucinations, dysfunctional integration of PFC input to the associative striatum may be especially important for delusional symptoms in schizophrenia.…”

Section: Psychosis: a Consequence Of Network Dysfunctionmentioning

confidence: 99%

Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience

et al. 2018

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The stagnation in drug development for schizophrenia highlights the need for better translation between basic and clinical research. Understanding the neurobiology of schizophrenia presents substantial challenges but a key feature continues to be the involvement of subcortical dopaminergic dysfunction in those with psychotic symptoms. Our contemporary knowledge regarding dopamine dysfunction has clarified where and when dopaminergic alterations may present in schizophrenia. For example, clinical studies have shown patients with schizophrenia show increased presynaptic dopamine function in the associative striatum, rather than the limbic striatum as previously presumed. Furthermore, subjects deemed at high risk of developing schizophrenia show similar presynaptic dopamine abnormalities in the associative striatum. Thus, our view of subcortical dopamine function in schizophrenia continues to evolve as we accommodate this newly acquired information. However, basic research in animal models has been slow to incorporate these clinical findings. For example, psychostimulant-induced locomotion, the commonly utilised phenotype for positive symptoms in rodents, is heavily associated with dopaminergic activation in the limbic striatum. This anatomical misalignment has brought into question how we assess positive symptoms in animal models and represents an opportunity for improved translation between basic and clinical research. The current review focuses on the role of subcortical dopamine dysfunction in psychosis and schizophrenia. We present and discuss alternative phenotypes that may provide a more translational approach to assess the neurobiology of positive symptoms in schizophrenia. Incorporation of recent clinical findings is essential if we are to develop meaningful translational animal models.

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Section: Psychosis: a Consequence Of Network Dysfunctionmentioning

confidence: 99%

Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience

et al. 2018

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“…Other studies have observed higher rates of ictal fear, bilateral independent discharges, and gross structural lesions in PIP [16] while additional studies show no differentiating EEG findings between psychotic and nonpsychotic PWE [17]. Yet another case study has shown a patient with right temporal lobe epilepsy undergoing a hyper-religious psychotic experience, with increased activity in the left prefrontal cortex suggesting a possible mechanism related to prefrontal lobe processes rather than medial temporal-lobe processes [18].…”

Section: Discussionmentioning

confidence: 99%

"You Are The One Who Was Beating Me": A Case Report of a Patient with Postictal Psychosis Secondary to Bilateral Temporal Lobe Epilepsy

Ngo¹,

Camacho

Singh

2019

Cureus

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Postictal psychosis is a rare but potentially serious complication in patients with seizure disorders. There is no consensus on best practices in managing and treating postictal psychosis as well as other psychoses of epilepsy, but current research is investigating topics such as adherence to seizure medications and antipsychotic administration during or before psychosis and addressing psychosocial stressors as potential components of effective treatment. We present a case report detailing a patient's lengthy history of postictal psychosis due to her underlying temporal lobe epilepsy; her disease course as correlated by a diagnostic electroencephalogram (EEG), her history of medication nonadherence, and the treatment of postictal psychosis are also discussed.

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“…Moreover, in the teaching of Hassidism, an influential 18th century east-European messianic Jewish movement, every single person who follows the commandments is taking part in the Messianic mission [58,59]. These examples are dependent on the cultural environment in a specific place and time [60]. Likewise, such painters of religious figures may be perceived as sinners and may be executed in one cultural or political scenario, admired in another, or subjected to academic research, but no one will relate to them positive symptoms of schizophrenia.…”

Section: From Illusory Experience To Cultural Experience Art and Religionmentioning

confidence: 99%

Agency, Ownership and the Potential Space

Arzy

2021

Brain Sciences

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The potential space, the space between the experiencer and the experience, is at the heart of Winnicott’s theory. The concepts of agency of one’s actions and ownership of one’s experience have been recently applied to such a space lying in between the experiencing self and the mental (cognitive) map she creates, representing her surroundings. Agency is defined as “the sense that I am the one who is generating the experience represented on a mental map”, while ownership is defined as “the sense that I am the one who is undergoing an experience, represented on a mental map”. Here these concepts are introduced and applied to five main realizations of Winnicott’s potential space: Playing, transitional phenomena, the therapeutic space, culture and creativity. Through theoretical constructs and clinical analyses, it is shown how agency and ownership, and their mutual interrelations, may help to better understand Winnicott’s theory with implications to clinical practice.

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“God has sent me to you”: Right temporal epilepsy, left prefrontal psychosis

Cited by 14 publications

References 35 publications

Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience

Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience

"You Are The One Who Was Beating Me": A Case Report of a Patient with Postictal Psychosis Secondary to Bilateral Temporal Lobe Epilepsy

Agency, Ownership and the Potential Space

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