Going Viral 2019

Martinez, Jose Dario; Garza, Jesús Alberto Cárdenas‐de la; Cuéllar-Barboza, Adrián

doi:10.1016/j.det.2018.07.008

Cited by 39 publications

(22 citation statements)

References 66 publications

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“…Patients diagnosed with chikungunya and Zika were older and predominantly female. Rash and/or arthralgia in conjunction with fever are typical clinical manifestations of chikungunya and Zika infections (Duffy et al, 2009;He et al, 2017;Langsjoen et al, 2016;Martinez et al, 2019;Pineda et al, 2016;Rosario et al, 2015). Although lower than rates reported elsewhere, arthralgia rates among chikungunya cases in our dataset were consistent with previously documented rates among individuals diagnosed with chikungunya in the Dominincan Republic (Langsjoen et al, 2016).…”

Section: Multiple Endemic and Emerging Mosquito-borne Virus Outbreakssupporting

confidence: 89%

Asynchronicity of endemic and emerging mosquito-borne disease outbreaks in the Dominican Republic

Petrone

Earnest

Lourenço

et al. 2020

Preprint

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Mosquito-borne viruses pose a perpetual public health threat to countries and territories in the Carribean due to the region's tropical climate and seasonal reception of international tourists. Outbreaks of the emerging viruses chikungunya and Zika in 2014 and 2016, respectively, demonstrated the rapidity with which these viruses can spread between islands. At the same time, the number of reported dengue fever cases, caused by the endemic dengue virus, has steadily climbed over the past decade, and a large dengue outbreak that began sweeping through this region in 2019 continues in 2020. Sustainable disease and mosquito control measures are urgently needed to quell virus transmission in the long term and prevent future outbreaks from occurring. To improve upon current surveillance methods, we analyzed temporal and spatial patterns of chikungunya, Zika, and dengue outbreaks reported in the Dominican Republic between 2012 and 2018. The viruses that caused these outbreaks are transmitted by Aedes mosquitoes, which are sensitive to seasonal climatological variability. In this study, we evaluated whether climate and the spatio-temporal dynamics of past dengue outbreaks could inform when and where future emerging disease outbreaks might occur. We found that the temporal and spatial distribution of emerging disease outbreaks did not conform to those of seasonal dengue outbreaks. Rather, the former occurred when climatological conditions were suboptimal for Aedes activity. Provincial dengue attack rates did not correspond to those of emerging diseases. Our study also provides evidence for under-reporting of dengue cases, especially following the 2016 Zika outbreak. We advocate for the implementation of a sustainable and long-term surveillance system to monitor the spread of known mosquito-borne viruses and to identify emerging threats before they cause outbreaks. Specifically, we recommend the use of febrile illness incidence, case fatality rates, and serosurveys during inter-outbreak periods to better understand rates of transmission and asymptomatic infection.

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Section: Multiple Endemic and Emerging Mosquito-borne Virus Outbreakssupporting

confidence: 89%

Asynchronicity of endemic and emerging mosquito-borne disease outbreaks in the Dominican Republic

Petrone

Earnest

Lourenço

et al. 2020

Preprint

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“…Although many viral infections can be associated with skin manifestations [47][48][49][50] , cutaneous symptoms have rarely been reported in association with COVID-19 [51] . In China, 0.2-1.2% of 1099 COVID-19 patients had a rash [25] .…”

Section: Cutaneous Manifestationsmentioning

confidence: 99%

Extra-respiratory manifestations of COVID-19

Lai

Lee

et al. 2020

International Journal of Antimicrobial Agents

293

271

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Coronavirus disease 2019 , caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global health threat. Although most patients with COVID-19 manifest fever and respiratory tract symptoms, SARS-CoV-2 infection may also involve other organs/systems and present with extra-respiratory manifestations, including cardiac, gastrointestinal, hepatic, renal, neurological, olfactory, gustatory, ocular, cutaneous and haematological symptoms. Occasionally, these extra-respiratory symptoms/signs represent the initial presentation of SARS-CoV-2 infection, prior to fever or respiratory manifestations. Therefore, this comprehensive review of the extra-respiratory manifestations of COVID-19 is intended to help clinicians better understand the range of clinical presentations associated with SARS-CoV-2 infection, allowing the consideration of COVID-19 in differential diagnoses. A screening test for SARS-CoV-2 should be performed when patients have these extra-respiratory manifestations. In addition, clinicians should be alerted to the adverse effects of anti-SARS-CoV-2 agents that can mimic the extrarespiratory manifestations of COVID-19. Moreover, some extra-respiratory manifestations, such as ocular and gastrointestinal involvement, may be caused by direct invasion of SARS-CoV-2. Therefore, protective measures should be taken while managing the associated clinical specimens. Finally, several extrarespiratory manifestations, such as cardiac involvement, acute kidney injury, coagulation disorders and thrombotic complications, could be associated with a poor prognosis.

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“…ZIKV is a recent emerging infectious disease characterized by its rapid spread and high virulence. Clinical manifestations following infection are generally mild, self-limited, and non-specific, which include symptoms such as fever, headache, arthralgia, myalgia, asthenia, and non-purulent conjunctivitis, found to be very similar to those caused by other arboviruses, therefore confounding the diagnosis [2]. Nevertheless, more severe outcomes have been described including the development of microcephaly in newborns, and grave neurological impairments in adults such as the Guillain Barrè syndrome (GBS) [89,92,93,94].…”

Section: Therapy Development and Approaches To Counteract Zikv Infmentioning

confidence: 99%

“…Nevertheless, this emerging arbovirus infection reached a global scale of diffusion since its arrival in the Americas in 2015, particularly devastating in the northeastern territories of Brazil. This virus was declared a public health emergency after reports of clinical complications such as neonatal microcephaly and other neurological disorders following infection [1,2]. Even if viral circulation is currently at low levels in endemic areas, presumably due to the development of herd immunity, Zika is still considered an ongoing challenge requiring strict surveillance [3].…”

Section: Introductionmentioning

confidence: 99%

“…ZIKV, a 50 nm enveloped and icosahedral particle with an 11 kb positive-strand RNA genome, is typically transmitted by bites from infected Aedes genus mosquitoes, in addition to mother-to-child transmission, blood transfusion, sexual contact, and organ transplantation [2]. ZIKV’s viral RNA genome encodes three structural proteins (membrane precursor prM, envelope E glycoprotein, and core C) and seven non-structural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5), which have been found to play a pivotal role in assisting viral pathogenesis and propagation by mediating viral entry and promoting viral translation and replication [5,6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Autophagy in Zika Virus Infection: A Possible Therapeutic Target to Counteract Viral Replication

Gratton

Agrelli

Tricarico

et al. 2019

IJMS

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Zika virus (ZIKV) still constitutes a public health concern, however, no vaccines or therapies are currently approved for treatment. A fundamental process involved in ZIKV infection is autophagy, a cellular catabolic pathway delivering cytoplasmic cargo to the lysosome for degradation—considered as a primordial form of innate immunity against invading microorganisms. ZIKV is thought to inhibit the Akt-mTOR signaling pathway, which causes aberrant activation of autophagy promoting viral replication and propagation. It is therefore appealing to study the role of autophagic molecular effectors during viral infection to identify potential targets for anti-ZIKV therapeutic intervention.

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Going Viral 2019

Cited by 39 publications

References 66 publications

Asynchronicity of endemic and emerging mosquito-borne disease outbreaks in the Dominican Republic

Asynchronicity of endemic and emerging mosquito-borne disease outbreaks in the Dominican Republic

Extra-respiratory manifestations of COVID-19

Autophagy in Zika Virus Infection: A Possible Therapeutic Target to Counteract Viral Replication

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