Goitre and hypothyroidism in the newborn after cutaneous absorption of iodine.

Jp, Chabrolle; Rossier, A

doi:10.1136/adc.53.6.495

Cited by 123 publications

(30 citation statements)

References 10 publications

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“…The figures reported in this work for uri nary iodine after vaginal application of PVP-I are of the same order of magnitude as the ones reported previously by our group after skin disinfection with povidone-iodine in preparation for cesarean section [24], These data confirm that a significant quantity of iodine is reabsorbed after cutaneous or vagi nal application of povidone-iodine [25][26][27][28], Our data confirm that iodine overload induced by vaginal douching with PVP-I is not severe enough to impair thyroid function in the mother [7,8].…”

Section: Discussionsupporting

confidence: 80%

Effect of Vaginal Douching with Povidone-Iodine during Early Pregnancy on the Iodine Supply to Mother and Fetus

Mahillon

Peers²,

Bourdoux³

et al. 1989

Neonatology

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Vaginal douching with polyvinylpyrrolidone iodine (PVP-I) during pregnancy results in maternal iodine overload and increases the iodine content of amniotic fluid. We evaluated the possible effects of this therapy on the thyroid of the fetus by investigating 62 women with a mean duration of amenorrhea of 20 weeks who solicited controlled abortion. Nineteen of them douched daily with PVP-I for 7 consecutive days before abortion (treated group). The other 43 women were not treated (control group). In both groups the iodine content was determined in the fetal thyroid and in amniotic fluid and maternal urine at the time of abortion. In addition, in the treated group the concentrations of iodine were also determined in amniotic fluid and urine before therapy and in urine after 4 days of therapy. There were no differences in the concentrations of iodine in urine and amniotic fluid in the control group and in the treated group before therapy. In the treated group urinary iodine increased from 6.1 ± (SEM) 0.8 µg/dl before therapy to 91 ± 20 µg/dl after 4 days and to 153 ± 60 µg/dl after 7 days of therapy (p < 0.001). In parallel, iodine in amniotic fluid increased from 1.2 ± 0.2 µg/dl before therapy to 3.7 ± 1.3 µg/dl after 7 days (p < 0.05). In both groups the iodine content of the fetal thyroid increased with gestational age. However, it increased more rapidly in the treated group (from 1 to 7.7 µg) than in the control group (from 1 to 2.5 µg), p < 0.05. In conclusion, routine vaginal douching with PVP-I during early pregnancy induces maternal iodine overload and markedly increases the iodine content not only of the amniotic fluid but also of the fetal thyroid, as soon as the trapping mechanism of iodide by the thyroid has started to develop. In view of the well-documented hypersensitivity of the fetal and neonatal thyroid to the blocking effect of excess iodide, the vaginal application of PVP-I is not recommended during pregnancy.

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Section: Discussionsupporting

confidence: 80%

Effect of Vaginal Douching with Povidone-Iodine during Early Pregnancy on the Iodine Supply to Mother and Fetus

Mahillon

Peers²,

Bourdoux³

et al. 1989

Neonatology

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“…Accordingly, we stained collagen tissues with a high atomic weight material, iodine tincture, which was selected for its excellent skin permeability and ready binding to organic compounds [23,24]. …”

Section: Discussionmentioning

confidence: 99%

Phase-Contrast Microtomography with Synchrotron Radiation Technology: A New Noninvasive Technique to Analyze the Three-Dimensional Structure of Dermal Tissues

et al. 2012

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Background: Since the three-dimensional (3-D) structure of dermal tissue has an important role in regulating cell behavior and directing the wound healing process, the characteristic of the 3-D structure of dermal tissue needs to be clarified. Objective: To explore the different 3-D structures between normal and scar dermal tissues. Material and Methods: Phase-contrast microtomography with synchrotron radiation technology was applied to detect the 3-D structure of dermal tissues. Results: The normal dermal tissue consists of elliptical structures formed by fiber bundles interwoven in a helical manner. A regular louver-like structure was observed on the fibers. In scar tissue, the fiber bundles were arrayed in parallel, the louver-like structures were disordered. Conclusion: The study demonstrates the mesoscopic difference between normal dermal tissue and scar tissue, suggests that the high level of interweaving capability of collagen is compromised/lost when dermal tissue is injured, and provides a basis for future studies.

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“…Transient hypothyroidism was observed af ter intrauterine application of contrast agents and after neonatal angiocardiography [1][2][3] and after skin disinfection with iodinecontaining solutions [4][5][6]. In other studies, however, no thyroid dysfunction was found after application of iodine-containing prepa rations in neonates [7][8][9][10], These discrepan-…”

mentioning

confidence: 89%

Iodine in Contrast Agents and Skin Disinfectants Is the Major Cause for Hypothyroidism in Premature Infants during Intensive Care

l’Allemand

Grüters²,

Beyer

et al. 1987

Horm Res

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In 51 sick newborns the influence of two different nonionic, iodine-containing contrast agents, Amipaque® (group 1) and Omnipaque® (group 2) and of long-term treatment with polyvinylpyrrolidone-iodine (PVP-I) (group 3) on thyroid function was studied. In the dose given, freshly dissolved Amipaque® releases roughly 100 µg ‘free’ iodide/kg body weight; this release may be even higher in the solubilized agent Omnipaque® because of increased breakdown. Urinary iodine excretion was elevated in all groups on day 5 after iodine exposure. In group 1 which included 17 term newborns, the median TSH level was normal after 5 days and 2 weeks, only 1 case of transient hypothyrotropinemia was observed; T₄ and T₃ median levels were in the lower range of normal. In groups 2 and 3, which included 8 preterm infants of 15 newborns and 9 preterm infants of 19 newborns, respectively, the median TSH values were elevated and T₄ and T₃ levels were very low. Hypothyroidism was diagnosed in 6 of the 8 preterm and in 1 of the 7 term newborns of group 2. In group 3, 7 of the 9 preterm and 3 of the 10 term newborns reacted with hypothyroidism. Eight preterm and 3 term newborns had to be substituted with thyroxine. The thyroid function of term newborns was less affected by Amipaque® or Omnipaque® than by PVP-I. The data show that preterm infants are very sensitive to an iodine load.

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Goitre and hypothyroidism in the newborn after cutaneous absorption of iodine.

Cited by 123 publications

References 10 publications

Effect of Vaginal Douching with Povidone-Iodine during Early Pregnancy on the Iodine Supply to Mother and Fetus

Effect of Vaginal Douching with Povidone-Iodine during Early Pregnancy on the Iodine Supply to Mother and Fetus

Phase-Contrast Microtomography with Synchrotron Radiation Technology: A New Noninvasive Technique to Analyze the Three-Dimensional Structure of Dermal Tissues

Iodine in Contrast Agents and Skin Disinfectants Is the Major Cause for Hypothyroidism in Premature Infants during Intensive Care

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