Gold and silver nanoparticles as tools to combat multidrug-resistant pathogens

Balestri, Arianna; Cardellini, Jacopo; Berti, Debora

doi:10.1016/j.cocis.2023.101710

Cited by 17 publications

(7 citation statements)

References 75 publications

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“…These nanoparticles demonstrate antimicrobial efficacy against viruses, bacteria, and chronic diseases. One notable advantage is their straightforward and cost-effective synthesis, coupled with their minimal harm to eukaryotic cells [ 102 ]. In addition, nano-materials can easily cross biological membranes and deliver TQ to specific locations in the body in a sustained fashion [ 103 ].…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Thymoquinone and Thymoquinone Nanoparticles against Diazinon-Induced Hepatic Injury in Rats: A Possible Protection Mechanism

Nassar,

El-Kholy,

El-Sawi

et al. 2023

Toxics

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The health benefits of thymoquinone (TQ) have been a significant focus of numerous studies. However, more research is needed to ascertain whether its nano-form can effectively treat or prevent chronic diseases. In this study, we investigated how thymoquinone and its nanoparticles can mitigate liver damage induced by diazinon in male Wistar rats and explored the intracellular mechanisms involved. Forty-two Wistar male rats (n = 42) were randomly allotted into seven groups. Group 1 served as the control. Group 2 (vehicle) consisted of rats that received corn oil via a gastric tube daily. In Group 3 (TQ), rats were given a daily oral administration of TQ (40 mg/kg bw). Group 4 (thymoquinone nanoparticles, NTQ) included rats that received NTQ (0.5 mg/kg bw) orally for 21 days. Group 5 (DZN) involved rats that were administered diazinon (DZN, 15 mg/kg bw) orally. In Group 6 (TQ + DZN), rats first received TQ orally, followed by DZN. Group 7 (NTQ + DZN) consisted of rats receiving NTQ orally, then DZN. After 21 days of treatment, the rats were euthanized. After oral administration of DZN, liver enzymes were significantly elevated (p < 0.05). Additionally, there were noticeable increases in oxidative injury markers, such as nitric oxide, malondialdehyde, redox oxygen radicals, and overall increases in hydrogen peroxide and liver protein carbonyl concentrations. This was accompanied by the upregulation of apoptotic markers (Bax, caspase9, caspase 3, bax/Bcl2 ratio), inflammatory cytokines (TNF-α, IL-6), and DNA damage. There was also a noteworthy decrease (p < 0.05) in the activities of antioxidant enzymes and anti-apoptotic markers. However, the oral administration of thymoquinone or its nanoparticle form mitigated these diazinon complications; our histopathological findings corroborated our biochemical and molecular observations. In conclusion, the significant antioxidant properties of thymoquinone, or its nanoparticle form, in tandem with the downregulation of apoptotic markers and inflammatory cytokines, provided a protective effect against hepatic dysfunction caused by diazinon.

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Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Thymoquinone and Thymoquinone Nanoparticles against Diazinon-Induced Hepatic Injury in Rats: A Possible Protection Mechanism

Nassar,

El-Kholy,

El-Sawi

et al. 2023

Toxics

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“…The usage of these plasmonic nanocomposites against microbes is a hot topic [18], and research still needs to be undertaken to yield results that can be transferred into practical applications. Au and Ag can enhance the photocatalytic antimicrobial action of ZnO, and they can also enhance treatment efficiency due to their intrinsic antimicrobial activity [21]. In a previous study, we demonstrated that ZnO/Au nanocomposites, composed of small ZnO nanorods and small AuNPs, work through a synergistic action, proving to be more effective against E. coli and S. aureus than ZnO alone [22].…”

Section: Introductionmentioning

confidence: 94%

Antibacterial and Photocatalytic Activity of ZnO/Au and ZnO/Ag Nanocomposites

Busila,

Musat,

Alexandru

et al. 2023

IJMS

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The use of a combination of nanoparticles as antimicrobial agents can be one strategy to overcome the tendency of microbes to become resistant to antibiotic action. Also, the optimization of nano-photocatalysts to efficiently remove persistent pollutants from wastewater is a hot topic. In this study, two composites ZnO/Au (1% wt.) and ZnO/Ag (1% wt.) were synthesized by simple aqueous solution methods. The structure and morphology of the r nanocomposites were analyzed by structural and optical characterization methods. The formation of AuNPs and AgNPs in these experiments was also discussed. The antimicrobial properties of ZnO, ZnO/Au, and ZnO/Ag nanomaterials were investigated against Gram-negative bacteria (Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus). The results showed an increase of 80% in the antimicrobial activity of ZnO/Au against Pseudomonas aeruginosa compared with 30% in the case of ZnO/Ag. Similarly, in the case of the S. aureus strain tests, ZnO/Au increased the antimicrobial activity by 55% and ZnO/Ag by 33%. The photocatalytic tests indicated an improvement in the photocatalytic degradation of methylene blue (MB) under UV irradiation using ZnO/Au and ZnO/Ag nanocomposites compared to bare ZnO. The photocatalytic degradation efficiency of ZnO after 60 min of UV irradiation was ∼83%, while the addition of AuNPs enhanced the degradation rate to ∼95% (ZP2), and AgNP presence enhanced the efficiency to ∼98%. The introduction of noble metallic nanoparticles into the ZnO matrix proved to be an effective strategy to increase their antimicrobial activity against P. aeruginosa and S. aureus, and their photocatalytic activity was evaluated through the degradation of MB dye. Comparing the enhancing effects of Au and Ag, it was found that ZnO/Au was a better antimicrobial agent while ZnO/Ag was a more effective photocatalyst under UV irradiation.

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“…Several metals, such as silver or copper, have demonstrated notable antibacterial effects, opening new avenues for combating microbial infections. [5][6][7][8][9] In addition, combinations of various metals in nanomaterials present numerous advantages compared to nanoparticles consisting of a single metal. These advantages include improved properties, leading to synergistic effects and customized features, multifunctionality, stability, cost-effectiveness, and the potential for novel applications.…”

Section: Introductionmentioning

confidence: 99%

“…21 Furthermore, the combination of two metals could produce synergistic effects that enhance the activity of bionanohybrids. 8,10,13 To evaluate their antibacterial effectiveness, the Cu-Ag bionanohybrids were confronted to several bacterial strains, including Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. These strains were chosen because they are among the top six pathogens responsible for the most deaths due to antimicrobial resistance, according to the literature.…”

Section: Introductionmentioning

confidence: 99%

CuAgNPs-enzyme Biohybrids as Antimicrobial nanomaterials

Ortega-Nieto,

Losada-Garcia,

Domingo-Calap

et al. 2024

Preprint

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Multidrug-resistant bacterial infections have become major threats to public health worldwide. Thus, bimetallic Ag-Cu nanoparticles-enzyme biohybrids has been developed. Different bimetallic bionanohybrids were synthesized with different contents of Ag, by the direct incubation of a previous synthesized Cu3(PO4)2NPs-CALB hybrid with silver salt in aqueous media and r.t. They were fully characterized, determining silver phosphate as metal species, and different nanoparticles sizes depending on the amount of silver used. HAADF-STEM analyses demonstrated the formation of individual Ag3PO4 NPs on the Cu-CALB nanoflowers. The catalytic reductase or oxidase-like activities of the bimetallic biohybrids was also affected being higher values when lower amount of silver was used. This effect was corroborated in their antimicrobial efficacy against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Mycobacterium smegmatis. Results indicate that the presence of small content on silver in the bimetallic hybrids highly enhanced the antibacterial activity compared to initial Cu36@CALB hybrid. Optimal amount of silver has been found corresponding to the bimetallic Ag4Cu32@CALB hybrid which showed the strongest antibacterial effect, with log reductions of 7.6, 4.3 and 3.9 for K. pneumoniae, P. aeruginosa, E. coli, and 1.8 for M. smegmatis. Overall, these novel nanomaterials are a promising alternative for fight against different pathogens.

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Gold and silver nanoparticles as tools to combat multidrug-resistant pathogens

Cited by 17 publications

References 75 publications

Ameliorative Effect of Thymoquinone and Thymoquinone Nanoparticles against Diazinon-Induced Hepatic Injury in Rats: A Possible Protection Mechanism

Ameliorative Effect of Thymoquinone and Thymoquinone Nanoparticles against Diazinon-Induced Hepatic Injury in Rats: A Possible Protection Mechanism

Antibacterial and Photocatalytic Activity of ZnO/Au and ZnO/Ag Nanocomposites

CuAgNPs-enzyme Biohybrids as Antimicrobial nanomaterials

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