Abstract:Over the past few years, substantial progress has been achieved in the development of nitroso-related organic chemistry. Annulations of nitroso compounds with other π-conjugated systems, especially the notable hetero Diels-Aldertype reaction, have drawn much interest from organic chemists, because of their regioselective, enantioselective and highly efficient advantages. In addition, the N-nitroso moiety can also be employed as powerful and transformable directing group in specific C-H direct functionalization reactions. Herein, we summarized the versatile applications of nitroso compounds as useful building blocks in the selective synthesis of diverse molecules in recent years.