Abstract:Due to the linear coordination nature of gold(I) catalysts, achieving high enantiocontrol in asymmetric gold catalysis is a great challenge. To improve the enantiocontrol of gold catalysis, an ion-pairing strategy was therefore proposed. A series of bifunctional P,N ligands based on chiral spirocyclic and biaryl scaffolds were synthesized and applied in the gold(I)-catalyzed desymmetric lactonization of alkynylmalonic acids. A wide range of chiral lactones containing an α-position quaternary stereocenter were … Show more
This cutting-edge research work presents a comprehensive and in-depth theoretical investigation on the mechanism, selectivity patterns, and ligand effects in gold(i)-catalyzed annulations between ynamides and isoxazoles.
This cutting-edge research work presents a comprehensive and in-depth theoretical investigation on the mechanism, selectivity patterns, and ligand effects in gold(i)-catalyzed annulations between ynamides and isoxazoles.
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