Gold catalyzed double condensation reaction: Synthesis, antimicrobial and cytotoxicity of spirooxindole derivatives

Gold catalyzed synthesis of tetrahydropyrimidines and octahydroquinazolines under ball milling conditions and evaluation of anticonvulsant potency

“…2H2O, 34 which can serve as both an oxophilic as well as a carbophilic catalyst, we initiated our studies using this particular catalyst. We aimed at solvent-free conditions, however, in order to drive the reaction between the substrates, the reactants have to be close enough, which we thought could be achieved by mechanical chemistry.…”

“…As part of our research interests on new synthetic methodologies for pharmacologically important molecules, [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] we have demonstrated the catalytic application of gold for the construction of various structurally challenging carboand heterocycles. [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] In order to circumvent the aforementioned limitations linked with the synthesis of dihydropyrimidines, coupled with our research interests in gold catalysis, we have now investigated the synthesis of both tetrahydropyrimidines and octahydroquinazolines under the catalytic influence of gold. Towards this end, we herein report an improved methodology for the solvent-free synthesis of tetrahydrohydropyrimidine / octahydroquinazoline derivatives under mechanochemical conditions in presence of Au(III) as catalyst.…”

Supercritical water assisted preparation of recyclable gold nanoparticles and their catalytic utility in cross-coupling reactions under sustainable conditions

“…[19][20][21][22][23][24] On the other hand, it is pertinent to mention that the catalytic potential of AuNPs is exemplied in oxidative esterication and hydrogen transfer reactions. 25 As part of our research interest in new reaction development [26][27][28][29][30] based on gold catalysis, [31][32][33][34][35][36][37] we became interested in the sustainable preparation of AuNPs and subsequent catalytic application in cross-coupling reactions. In particular, we desired to develop a simple and practical procedure for AuNP catalyzed Sonogashira and Suzuki reactions.…”

Synthesis and Biological Evaluation of New Isatin‐Based QACs with High Antimicrobial Potency

“…The constantly growing studies on the methods of synthesis and modification of oxindole cycle is primarily due to these compounds possess a wide spectrum of physiological activity ‐ antiviral, antifungal, antibacterial, antiproliferative, antitumor, anti‐inflammatory, antihypertensive and anticonvulsant . Among a wide range of isatin derivatives, compounds containing the C=N bond in position 3 ‐ Schiff bases and acyl hydrazones, which exhibit antitumor, herbicidal, antitubercular and antimicrobial activity are of particular interest.…”