Gold-Catalyzed Tandem Annulations of Pyridylhomopropargylic Alcohols with Propargyl Alcohols

Alcohol Dehydrogenases and N‐Heterocyclic Carbene Gold(I) Catalysts: Design of a Chemoenzymatic Cascade towards Optically Active β,β‐Disubstituted Allylic Alcohols

“…This is in accordance with the already described reactivity of furan derivatives in combination with gold catalysis, occurring e.g., furan‐alkyne intramolecular cyclizations or other rearrangements [58] . At this point, the use of pyridine derivatives was omitted since it is well known that the basic nitrogen atom coordinates to the gold catalyst leading to a dramatic loss of the metal activity, [59] requiring therefore higher reaction temperatures [60] that on the other hand would not be compatible with a second enzymatic reaction.…”

Bi(OTf)3-Catalyzed Alkyl-Intercepted Meyer–Schuster Rearrangement of Propargylic Alcohols for the Synthesis of 1,2,3,5-Tetrasubstituted Pentane-1,5-diones

“…On the basis of the knowledge of the Meyer–Schuster rearrangement , and the mechanistic evidence shown in Scheme , we proposed a possible mechanism of present transformation (Scheme ). Initially, the loss and addition of a molecular water in the presence of catalyst led to enol II , and recycled the catalyst.…”

Development of novel transition metal-catalyzed synthetic approaches for the synthesis of a dihydrobenzofuran nucleus: a review

“…Au-catalyzed synthesis of heterocycles via [3 + 2] annulation portrays an appealing strategy as it offers complete regio- and stereo-control for introducing the functional groups. Utilizing this strategy, Liang 112 et al in 2021 described the synthesis of polycyclic dihydrobenzofuran derivatives 215 via gold and Cu-catalyzed tandem reaction. In their synthetic approach, propargyl alcohols 212 were coupled with pyridylhomopropargylic alcohols 213 via a number of processes, i.e.…”