Gold‐Catalyzed Transformations of Propargyl Alcohols and Propargyl Amines

Abstract

Propargyl alcohols and propargyl amines are useful building blocks for the synthesis of heterocycles and complex molecules. The development of homogeneous gold catalysis has greatly benefited organic synthesis. This Focus Review presents an overview of the gold-catalyzed transformations of propargyl alcohols and amines.

Recent Developments in the Meyer‐Schuster Rearrangement

“…[4] On the other hand gold catalysis, as well as transition metal-catalyzed reactions of propargylic derivatives, have been much studied during the last decade, and therefore the progress for MSR has also been included in corresponding review articles. [5,6] Further, a review on cascade reactions includes also a few examples with MSR, [7a] and a very recent review on propargylic alcohols chemistry reports also a number of MSRs. [7b] The goal of this review is to give a comprehensive coverage of the literature on the progress in MSR during the last decade (2010-2020).…”

An Efficient A3 Coupling Catalyst Based on a Silver Complex Bearing N‐Heterocyclic Carbene and Homoscorpionate Bis(3‐methyl‐mercaptoimidazolyl)borate Ligands

“…Propargylamines constitute an important class of compounds and they have widespread utility e. g., as intermediates for the synthesis of organic molecules . Propargylamines are also utilized for the preparation of natural products and therapeutic drug molecules .…”

“…Propargylamines constitute an important class of compounds and they have widespread utility e. g., as intermediates for the synthesis of organic molecules. [1][2][3][4][5][6] Propargylamines are also utilized for the preparation of natural products and therapeutic drug molecules. [7] Some pharmaceutically active propargylamines include those that are used in the treatment of Parkinson and Alzheimer diseases.…”

Gold(I)‐Catalyzed Synthesis of Six‐Membered P,O‐Heterocycles via Hydration/Intramolecular Cyclization Cascade Reaction

“…Owing to their advantages in activation of carbon‐carbon π bonds, gold catalysts have shown their power in the transformation of alkyne‐containing substrates . For example, fruitful achievements have been made in the gold‐catalyzed rearrangement of propargyl esters, cycloisomerizations of enynes, cyclizations of diynes, oxidation of alkynes by N ‐oxides and transformations of propargyl alcohols and propargyl amines . Gold complexes have also been used to promote the synthesis of heterocyclic phosphorus compounds, which are useful in organic synthesis, medicinal chemistry, and material science.…”