Gold chemistry with ferrocene derivatives as Ligands

Abstract

The synthesis and properties of gold complexes with l,l'-bis(diphenylphosphino)ferrocene (dppf), its sulfide (dppfS 2 ) and disubstituted dithiocarbamate or thiolate ferrocene derivatives as ligands are reviewed. The ability of these metalloligands to modify their steric bite in order to adapt to different geometric requirements of the metal centres has allowed the synthesis of several gold complexes with unusual geometries and novel structures. The potential of the new compounds for a number of applications is considered.

Synthetic Control of Mitochondrial Dynamics: Developing Three-Coordinate Au(I) Probes for Perturbation of Mitochondria Structure and Function

“…9 − 13 Their unique properties have alluded to unique behavior both in vivo and in vitro in comparison to other transition metal-based alternatives. 14 − 19 Despite the breadth of gold complex libraries developed thus far, the unique geometry of tricoordinated Au(I) complexes 20 − 25 are uncommon and their therapeutic potential left untapped. 26 − 28 Bourrisou and co-workers have demonstrated catalytic capability with tricoordinate complexes due to their distinct reactivity.…”

“…The development of gold-based small-molecules for biological use received a major boost following the FDA approval of auranofin for the treatment of rheumatoid arthritis . Over the past decade, several gold compounds have been synthesized as potential therapeutic agents for a plethora of diseases. − Their unique properties have alluded to unique behavior both in vivo and in vitro in comparison to other transition metal-based alternatives. − Despite the breadth of gold complex libraries developed thus far, the unique geometry of tricoordinated Au­(I) complexes − are uncommon and their therapeutic potential left untapped. − Bourrisou and co-workers have demonstrated catalytic capability with tricoordinate complexes due to their distinct reactivity. ,− We sought to explore the effect of these geometrically unique gold complexes on mitochondria morphology and functional consequences in normal or cancerous epithelial cells.…”