Gold concentration in blood in relation to the number of gold restorations and contact allergy to gold

Abstract

Previous studies have demonstrated an association between gold allergy and the presence of dental gold restorations. The aim of the present study was to investigate the relationship between the concentration of gold in blood (B-Au) and the number of tooth surfaces with gold alloys in subjects with and without contact allergy to gold. In 80 patients referred for patch testing because of eczematous disease, blood samples were taken and analyzed for B-Au using inductively coupled plasma mass spectrometry. The detection limit for the Au determination was 0.04 microg/L. In addition, a dentist made a clinical and radiological examination of the patients and registered the number of dental gold surfaces. Patients with dental gold restorations had a statistically significantly higher B-Au in Mann-Whitney U test (P = 0.025), (range < 0.04-1.07 microg/L) than patients without (range < 0.04-0.15 microg/L). Furthermore, a positive correlation was found between B-Au and the number of dental gold surfaces (P < 0.01). There was no statistically significant difference in B-Au between persons with and without contact allergy to gold. The study thus indicates that gold is released from dental restorations and taken tip into the circulation.

Contact allergy to gold in patients with gold‐plated intracoronary stents

“…However, gold release from gold alloys used in jewellery has been demonstrated (20), and an experimental study has indicated the importance of skin exposure to gold-plated earrings as significant for the development of allergic contact dermatitis from gold (21). Furthermore, we have demonstrated that dental gold may be decisive for sensitization to gold (22) and that there is a statistically significant correlation between the amount of dental gold and the blood level of gold (23). It is known that systemic provocation with an intramuscularly given gold salt to patients with contact allergy to gold gives a clinical flare-up reaction (24).…”

Contact Allergy and Vulvar Lichen Sclerosus et Atrophicus

“…The major sensitizers in these groups are present in most baseline patch test series. Several of the allergens found in the dental series can cause systemic reactions [19,20] and oral lichenoid reactions may be caused by sensitizers such as mercury and gold in dental materials [19,20]. Dental materials in the mouth are constantly exposed to saliva which may extract possible sensitizers.…”

“…Dental materials in the mouth are constantly exposed to saliva which may extract possible sensitizers. The sensitizers may be absorbed in the gastrointestinal canal and hereby cause a systemic allergic contact dermatitis or aggravate an existing skin disease [14,20].…”

“…that might be used locally and for substances that are known to, or theoretically might, cause systemic reactions or flare up [18][19][20][21][22]. With regard to locally used products within the genital area, preservatives, fragrance substances, and corticosteroids are examples of sensitizers known to be present in products used in the genital area for hygiene purposes or for the treatment of GLS [2,14,20].…”

Prevalence of Metal Sensitivity in Symptomatic Patients with Dental Alloy Restorations and the Relation to the Clinical Manifestations

“…Metal ions are releasing from dental alloys, precious and non-precious, and are causing adverse health effects including allergies (2,5,13). cases of clinical failure as a result of local or systemic allergic manifestations have been reported (3,4,6,7,8,9).…”