Gold embedded chitosan nanoparticles with cell membrane mimetic polymer coating for pH-sensitive controlled drug release and cellular fluorescence imaging

Ma, Ke; Cheng, Yongbin; Wei, Xingmei; Chen, Daijun; Zhao, Xiaoli; Jia, Pengxiang

doi:10.1177/0885328220952594

Cited by 17 publications

(13 citation statements)

References 52 publications

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“…Typically, the core of the NP, which must be delivered and released at the target site, consists of its therapeutic agent and framework, which are shielded by cell membranes isolated from source cells (Gao et al, 2016;Zhang et al, 2017;Pitchaimani et al, 2018;Yang et al, 2018;Cao et al, 2020;Gong et al, 2020;Poudel et al, 2020;Wu et al, 2020;Chen et al, 2021a;Li et al, 2021a;Wang et al, 2021a;Zhao et al, 2021a;Wu et al, 2021c;Fan et al, 2021;Shen et al, 2021). Frontiers in Bioengineering and Biotechnology frontiersin.org Pitchaimani et al, 2018;Bidkar et al, 2019;Wang et al, 2019;Cao et al, 2020;Poudel et al, 2020;Wu et al, 2020;Wang et al, 2021a;Liu et al, 2021;Ma et al, 2021;Zhang et al, 2021;Cai et al, 2022).…”

Section: Cores Of Cell Membranecamouflaged Npsmentioning

confidence: 99%

“…Chitosan is a polycationic macromolecules derived from the alkaline deacetylation of chitin, and it is composed of randomly distributed β-(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine (Bhattacharyya and Ghosh, 2020;Ma et al, 2021). It is a porous material with a high surface areas and interconnected pore channels, and it is a good candidate to be used as an adsorbent.…”

Section: Chitosanmentioning

confidence: 99%

“…It is a porous material with a high surface areas and interconnected pore channels, and it is a good candidate to be used as an adsorbent. In that vein, Ma et al (Ma et al, 2021) employed a one-pot method to fabricate gold-embedded chitosan NPs (Au@CS NPs), which were modified by applying benzaldehyde-terminated poly [(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC). The obtained Au@CS-PMPC NPs had a diameter of 135 nm and showed features of elevated colloidal stability, high loading capacity of drugs, pHresponsive drug release, superior biocompatibility, and marked fluorescence emission.…”

Section: Chitosanmentioning

confidence: 99%

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Research update on cell membrane camouflaged nanoparticles for cancer therapy

Wang

2022

Front. Bioeng. Biotechnol.

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Cell membrane-camouflaged biomimetic functionalization of nanoparticles has emerged as a promising strategy for cancer theranostics. These cell membranes used for camouflaging are generally isolated from natural or engineered erythrocytes, neutrophils, macrophages, T lymphatic cells, stem cells, and cancer cells. The camouflaging strategy of coating nanoparticles with cell membranes allows for tumor homotypic targeting through self-recognition as source cells, immune evasion, and a prolonged blood circulation time, thereby improving the effective payload delivery and tumor therapy. More so, some engineered cell membranes with functionalized peptides, proteins and moieties on membrane surface can be transferred for therapy in the same time. In this review, we summarize the latest research on various types of cell membrane-camouflaged nanoparticles aimed at anti-cancer therapy, focusing on the biological advantages of different cell membranes, constitutions of nanoparticles, fabrication processes, key findings, potential therapies, and discuss the major challenges and future opportunities.

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Section: Cores Of Cell Membranecamouflaged Npsmentioning

confidence: 99%

Section: Chitosanmentioning

confidence: 99%

Section: Chitosanmentioning

confidence: 99%

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Research update on cell membrane camouflaged nanoparticles for cancer therapy

Wang

2022

Front. Bioeng. Biotechnol.

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“…Polymers undergo pH-sensitive conformational changes in three different ways: a) dissociation, b) destabilization (via collapse or swelling), and c) changes or partition coefficient between the drug and the vehicle. Among the most commonly used pH-sensitive polymers for decorating AuNPs, we encounter anionic polymers, such as poly(acrylic acid) (PAA) and poly(methyl methacrylate) (PMMA) [ 48 , 49 ], and cationic polymers, such as chitosan (CS) [ 50 ] and poly(4-vinyl pyridine) (PVP) [ 51 ]. For instance, commercially available organic molecules have been utilized to decorate and design pH-responsive nanosystems.…”

Section: Overview: Green Biosynthesis Of Metallic Nanoparticlesmentioning

confidence: 99%

Green Metallic Nanoparticles for Cancer Therapy: Evaluation Models and Cancer Applications

et al. 2021

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Metal-based nanoparticles are widely used to deliver bioactive molecules and drugs to improve cancer therapy. Several research works have highlighted the synthesis of gold and silver nanoparticles by green chemistry, using biological entities to minimize the use of solvents and control their physicochemical and biological properties. Recent advances in evaluating the anticancer effect of green biogenic Au and Ag nanoparticles are mainly focused on the use of conventional 2D cell culture and in vivo murine models that allow determination of the half-maximal inhibitory concentration, a critical parameter to move forward clinical trials. However, the interaction between nanoparticles and the tumor microenvironment is not yet fully understood. Therefore, it is necessary to develop more human-like evaluation models or to improve the existing ones for a better understanding of the molecular bases of cancer. This review provides recent advances in biosynthesized Au and Ag nanoparticles for seven of the most common and relevant cancers and their biological assessment. In addition, it provides a general idea of the in silico, in vitro, ex vivo, and in vivo models used for the anticancer evaluation of green biogenic metal-based nanoparticles.

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“…Gold nanoparticles (AuNPs) attracted great attention due to their high localized surface plasmon resonance (LSPR) [5,6]. Chitosan (CS) showed promising advantages in drug delivery systems, such as biocompatibility and biodegradability [7,8]. The 6MP is one of the most effective anti-cancer agents used to treat inflammatory diseases [9,10].…”

Section: Introductionmentioning

confidence: 99%

Laser Enhanced Combinatorial Chemo-photothermal Therapy of Green Synthesis Gold Nanoparticles Loaded with 6Mercaptopurine on Breast Cancer Model

et al. 2022

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Purpose We tend to evaluated a method for loading 6Mercaptopurine (6MP) on green synthesized hybrid chitosan gold nanoparticles (AuNPs) forming 6MP-AuNPs nanocomposite for the first time in combinatorial chemo-photothermal therapy. Methods The AuNPs were synthesized using chitosan as a reducing and capping agent. Different concentrations of 6MP were mixed AuNPs. Cells were incubated with 6MP and 6MP loaded AuNPs for 48 h and then exposed to laser. Results AuNPs and 6MP-AuNPs nanocomposite have small sizes of 18 ± 4 and 25 ± 5 nm and exhibit high stability with Zeta potential of 55.9 ± 6.3 and 57 ± 4 mV. 6MP-AuNPs nanocomposite irradiated with Diode Pumped Solid State (DPSS) laser showed a maximum inhibition in cell viability reaching 63% at 1.25 µM. Conclusions A hybrid chitosan gold nanoparticle is a powerful anti-cancer drug carrier as well as photothermal agent in combinatorial chemo-photothermal therapy.

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Gold embedded chitosan nanoparticles with cell membrane mimetic polymer coating for pH-sensitive controlled drug release and cellular fluorescence imaging

Cited by 17 publications

References 52 publications

Research update on cell membrane camouflaged nanoparticles for cancer therapy

Research update on cell membrane camouflaged nanoparticles for cancer therapy

Green Metallic Nanoparticles for Cancer Therapy: Evaluation Models and Cancer Applications

Laser Enhanced Combinatorial Chemo-photothermal Therapy of Green Synthesis Gold Nanoparticles Loaded with 6Mercaptopurine on Breast Cancer Model

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