Gold Glyconanoparticles Based on Aldoses 6-Mercaptohexanoyl Hydrazones and Their Anti-Influenza Activity

Еrshov, A. Yu.; Martynenkov, A. A.; Lagoda, I. V.; Kopanitsa, M. A.; Zarubaev, Vladimir V.; Slita, Alexander V.; Buchkov, E. V.; Панарин, Е. Ф.; Yakimansky, Alexander V.

doi:10.1134/s1070363221090188

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…These preliminary data on the activity against the A/Puerto Rico/8/34 (H1N1) demonstrated the prospects of their further investigation for the search for efficient drugs for the prevention and treatment of acute respiratory viral infections [36] (Table 1).…”

Section: Gold(i) and Gold(iii) Complexesmentioning

confidence: 88%

“…Synthesized gold glyconanoparticles [37] (Table 1) were tested against the Influenza virus H1N1 (A/Puerto Rico/8/34) via a standard protocol [36]. The nanoparticles revealed [47] As a preliminary screen for anti-fibrotic activity, we used the Lx-2 cell morphology.…”

Section: Gold(i) and Gold(iii) Complexesmentioning

confidence: 99%

“…Synthesized gold glyconanoparticles [37] (Table 1) were tested against the Influenza virus H1N1 (A/Puerto Rico/8/34) via a standard protocol [36]. The nanoparticles revealed low cytotoxicity towards the MDCK cells (higher than 100 µg/mL) and high antiviral activity at concentrations of 3 and 6 µg/mL.…”

Section: Gold(i) and Gold(iii) Complexesmentioning

confidence: 99%

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Biological Activity of Gold Compounds against Viruses and Parasitosis: A Systematic Review

Fonseca

Aureliano

2022

BioChem

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In this contribution, we provide an overview of gold compound applications against viruses or parasites during recent years. The special properties of gold have been the subject of intense investigation in recent years, which has led to the development of its chemistry with the synthesis of new compounds and the study of its applicability in various areas such as catalysis, materials, nanotechnology and medicine. Herein, thirteen gold articles with applications in several viruses, such as hepatitis C virus (HCV), influenza A virus (H1N1), vesicular stomatitis virus (VSV), coronavirus (SARS-CoV and SARS-CoV-2), Dengue virus, and several parasites such as Plasmodium sp., Leishmania sp., Tripanossoma sp., Brugia sp., Schistosoma sp., Onchocerca sp., Acanthamoeba sp., and Trichomonas sp. are described. Gold compounds with anti-viral activity include gold nanoparticles with the ligands mercaptoundecanosulfonate, 1-octanethiol and aldoses and gold complexes with phosphine and carbene ligands. All of the gold compounds with anti-parasitic activity reported are gold complexes of the carbene type. Auranofin is a gold drug already used against rheumatoid arthritis, and it has also been tested against virus and parasites.

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Section: Gold(i) and Gold(iii) Complexesmentioning

confidence: 88%

Section: Gold(i) and Gold(iii) Complexesmentioning

confidence: 99%

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Biological Activity of Gold Compounds against Viruses and Parasitosis: A Systematic Review

Fonseca

Aureliano

2022

BioChem

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“…Additionally, for designing a potential carbohydrate-based anticancer vaccine, AuNPs were conjugated with T-cell helper peptides and sialyl-Tn and Lewis antigens, which were tumor-associated carbohydrate antigens overexpressed in several cancer types . In a recent study, it was claimed that gold glyconanoparticles decorated with condensation products of N -acetylamino- d -glucose, d -mannose, d -galactose, and l -fucose with 6-mercaptohexanoic acid hydrazide could be a promising efficient drug for acute respiratory viral infection treatments . The preliminary data showed that these gold glyconanoparticles at high doses had low toxicity in MDCK cells and also resulted in remarkable antiviral activity against the A/Puerto Rico/8/34 (H1N1) influenza virus at doses of 3 and 6 μg/mL.…”

Section: Introductionmentioning

confidence: 99%

“…34 In a recent study, it was claimed that gold glyconanoparticles decorated with condensation products of N-acetylamino-D-glucose, D-mannose, D-galactose, and L-fucose with 6-mercaptohexanoic acid hydrazide could be a promising efficient drug for acute respiratory viral infection treatments. 35 The preliminary data showed that these gold glyconanoparticles at high doses had low toxicity in MDCK cells and also resulted in remarkable antiviral activity against the A/Puerto Rico/8/34 (H1N1) influenza virus at doses of 3 and 6 μg/mL. Last but not least, a glyconanoparticles platform including 31 glycopolymers tailored with heterogeneous or homogeneous different sugar moieties, such as β-glucose, β-galactose, αmannose, β-N-acetyl glucosamine, and β-N-acetyl galactosamine (unconjugated with AuNPs), was reported.…”

Section: Introductionmentioning

confidence: 99%

Systematic Investigation of Cellular Response to Hydroxyl Group Orientation Differences on Gold Glyconanoparticles

Sarıçam,

Ercan Ayra,

Culha

2023

ACS Omega

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Nanoparticle (NP) surfaces act as the interface as they interact with living systems and play a critical role in defining their cellular response. The nature of these interactions should be well understood to design safer and more effective NPs to be used in a wide range of biomedical applications. At the moment, it is not clear how a subtle change in surface chemistry will affect an NP's behavior in a biological system. Thus, understanding the role of such a small change is critical and may allow one to fine-tune a biological response. In this study, the cellular response to −OH orientation differences generated on gold glyconanoparticles, which are recently considered promising therapeutic agents as they mimic a glycocalyx, is investigated. As model molecules, glucose and mannose (C2 epimer) as monosaccharides and lactose and maltose (galactose and glucose as free units, C4 epimer) as disaccharides were chosen to monitor the cellular response in A549, BEAS-2b, and MDA-MB-231 cells through cellular uptake, cytotoxicity, and cell cycle progression. The three cell lines gave various and remarkable cellular responses to the same subtle −OH differences on gold glyconanoparticles, and it is determined that not only −OH orientation differences but also the number of saccharides on gold glyconanoparticles affect the cellular response. It was shown that mannose (C2 epimer to glucose) was significant with the promise of being a therapeutic agent for lung cancer therapy, whereas the toxicological profile of MDA-MB-231 cells was affected by AuNPs− glucose the most. This study demonstrates that clearly small chemical alterations on a NP surface can result in a significant cellular response. It can be concluded that the −OH orientation at the second and fourth carbon of a carbohydrate ring has a critical role in designing and engineering novel gold glyconanoparticles (consisting of monolayer mono-or disaccharides) for a specific cancer therapy.

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Structure of the Products of 4-Mercaptobutyric Acid Hydrazide Condensation with a Series of Aldoses as Promising Ligands of Gold Glyconanoparticles for Biomedical Application

Martynenkov,

Lagoda,

Batyrenko

et al. 2024

Russ J Gen Chem

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Gold Glyconanoparticles Based on Aldoses 6-Mercaptohexanoyl Hydrazones and Their Anti-Influenza Activity

Cited by 6 publications

References 20 publications

Biological Activity of Gold Compounds against Viruses and Parasitosis: A Systematic Review

Biological Activity of Gold Compounds against Viruses and Parasitosis: A Systematic Review

Systematic Investigation of Cellular Response to Hydroxyl Group Orientation Differences on Gold Glyconanoparticles

Structure of the Products of 4-Mercaptobutyric Acid Hydrazide Condensation with a Series of Aldoses as Promising Ligands of Gold Glyconanoparticles for Biomedical Application

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