Gold(I)-Catalyzed Regioselective Hydroarylation of Propiolic Acid with Arylboronic Acids

Abstract

A gold-catalyzed intermolecular hydroarylation involving arylboronic acid has been disclosed. This carboxylic acid-directed arylation is highly regioselective and occurs at the less electrophilic carbon to afford α-aryl acrylic acids in attractive yields. This protocol offers easy access to NSAID precursors.

Metal-catalyzed Markovnikov-type selective hydrofunctionalization of terminal alkynes

“…74 Recently, Balamurugan and co-workers reported gold( i )-catalyzed Markovnikov-type selective hydroarylation of propiolic acid with organic boronic acids to α-carboxyl alkenes (Scheme 16(c)). 75…”