Gold(III) bis-thiosemicarbazonato complexes: synthesis, characterization, radiochemistry and X-ray crystal structure analysis

Bottenus, Brienne N.; Kan, Para; Jenkins, Tyler; Ballard, B.; Rold, Tammy L.; Barnes, Charles L.; Cutler, Cathy S.; Hoffman, Timothy J.; Green, Mark; Jurisson, Silvia S.

doi:10.1016/j.nucmedbio.2009.08.003

Cited by 27 publications

(34 citation statements)

References 45 publications

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“…(Table S1) and IR spectroscopic data analysis shows similarities in their structures. Complexes [37] recently reported the synthesis of complex 3 which was prepared through a different synthetic protocol than that described here.…”

Section: Lipophilicity Determinationmentioning

confidence: 99%

New bis(thiosemicarbazonate) gold(III) complexes inhibit HIV replication at cytostatic concentrations: Potential for incorporation into virostatic cocktails

Fonteh

Keter

Meyer

2011

Journal of Inorganic Biochemistry

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Section: Lipophilicity Determinationmentioning

confidence: 99%

New bis(thiosemicarbazonate) gold(III) complexes inhibit HIV replication at cytostatic concentrations: Potential for incorporation into virostatic cocktails

Fonteh

Keter

Meyer

2011

Journal of Inorganic Biochemistry

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“…Unfortunately, the chemistry of Au(III) is not straight-forward and both hydrolysis and reduction to Au(0) are problems that need to be overcome. At the radiotracer level, hydrolysis becomes an issue for Au(III) above pH 4; extracting (t-Bu 4 N)[ 198/199 AuCl 4 ] into an organic solvent such as CHCl 3 prior to reaction with the chelate addresses this issue [150]. …”

Section: Radiometal Chelate Considerationsmentioning

confidence: 99%

“…Recently, Bottenus and co-workers investigated a series of gold(III) bis-thiosemicarbazone complexes [150]. Although one of the complexes reported, Au(3,4-HxTSE) (Figure 10), showed favorable in vitro stability, biodistribution studies in CF-1 normal mice showed >50% ID/g remaining in the bloodstream at 4 h p.i.…”

Section: Radiometal Chelate Considerationsmentioning

confidence: 99%

“…Although one of the complexes reported, Au(3,4-HxTSE) (Figure 10), showed favorable in vitro stability, biodistribution studies in CF-1 normal mice showed >50% ID/g remaining in the bloodstream at 4 h p.i. with high lung uptake possibly resulting from complex binding to serum albumin [150]. Stabilizing Au(III) to reduction under in vivo conditions continues to be an issue that must be overcome to generate a potential 199 Au radiotherapeutic agent.…”

Section: Radiometal Chelate Considerationsmentioning

confidence: 99%

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Inorganic chemistry in nuclear imaging and radiotherapy: current and future directions

et al. 2012

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Summary Radiometals play an important role in diagnostic and therapeutic radiopharmaceuticals. This field of radiochemistry is multidisciplinary, involving radiometal production, separation of the radiometal from its target, chelate design for complexing the radiometal in a biologically stable environment, specific targeting of the radiometal to its in vivo site, and nuclear imaging and/or radiotherapy applications of the resultant radiopharmaceutical. The critical importance of inorganic chemistry in the design and application of radiometal-containing imaging and therapy agents is described from a historical perspective to future directions.

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“…Gold and its complexes have demonstrated unique biological and medical properties. 33 A number of Schiff base and thiosemicarbazonato complexes are prepared with 198 Au. 22 Similarly, information on the use of Au(III) complexes as anti-HIV agents is scarce; only a few reports have been recently published.…”

Section: Introductionmentioning

confidence: 99%

Potent selective inhibition of MMP-14 by chloroauric acid and its inhibitory effect on cancer cell invasion

Wang

et al. 2015

RSC Adv.

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Matrix metalloproteinases (MMPs) are a family of zinc-containing proteases with vital roles in extracellular matrix remodeling. The regulation of MMPs can modulate a number of cellular activities. The therapeutic potential of MMP inhibitors has been shown for diseases such as arthritis and cancer. This paper is the first to demonstrate that HAuCl 4 inhibits the activity of MMP-2 and MMP-13 as well as having a more specific inhibitory effect on MMP-14. The effect of HAuCl 4 on MMP-14 involves a non-competitive reversible inhibitory mechanism. Moreover, 0-50 mM HAuCl 4 did not affect the cell viability of HT-1080 human fibrosarcoma cells. However, HAuCl 4 at these concentrations showed significant inhibitory effects on the invasion of the HT-1080 cells, thereby suggesting that HAuCl 4 may modulate tumor cell behaviors by inhibiting MMP-14. These findings provide initial clues to further elucidate the biological activity of HAuCl 4 and its potential therapeutic value for related diseases.

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Gold(III) bis-thiosemicarbazonato complexes: synthesis, characterization, radiochemistry and X-ray crystal structure analysis

Cited by 27 publications

References 45 publications

New bis(thiosemicarbazonate) gold(III) complexes inhibit HIV replication at cytostatic concentrations: Potential for incorporation into virostatic cocktails

New bis(thiosemicarbazonate) gold(III) complexes inhibit HIV replication at cytostatic concentrations: Potential for incorporation into virostatic cocktails

Inorganic chemistry in nuclear imaging and radiotherapy: current and future directions

Potent selective inhibition of MMP-14 by chloroauric acid and its inhibitory effect on cancer cell invasion

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