Gold(III) heteroleptic complexes with SNS-thiosemicarbazonate ligands as cytotoxic agents: Experimental and computational insights into the mechanism of action

Silva, Amandha Kaiser da; Obata, Malu Mateus Santos; Candido, Pamela Aparecida; Lopes, Érica de Oliveira; Pavan, Fernando Rogério; Carneiro, Zumira Aparecida; Silva, Marcos Vinícius da; Oliveira, Carlo José Freire; Batista, Alzir A.; Oliveira, Ronaldo Junio de; Deflon, Victor M.; Maia, Pedro Ivo da Silva

doi:10.1016/j.poly.2022.115767

Cited by 4 publications

(6 citation statements)

References 59 publications

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“…Most of them have advanced databases such as GEMIS and GHGenious offering an energy database of numerous materials and transportation systems like types of fuels, LEM specializing in energy consumption, and BioGrace providing information on greenhouse gas emissions could be given as few examples of stated specifications 25. However, SimaPro, GaBi, openLCA, and Umberto have seen the most usage in studies 26 due to their wide range of applications rather than specializations.…”

Section: Softwarementioning

confidence: 99%

“…In order to conduct an LCA study utilizing any software available, the differences of that software should be known. SimaPro, GaBi, openLCA, and Umberto are all commercially available LCA software that is offered to researchers to employ, yet it is common to observe different results in the same study 26, 27. In an investigation conducted by Silva et al.…”

Section: Softwarementioning

confidence: 99%

“…According to researchers, sulfur trioxide emissions were major contributors to the AC category in openLCA and Umberto, whereas sulfur dioxide emissions had a different impact in GaBi and SimaPro. Sulfur dioxide had a larger impact factor (1.31) than sulfur trioxide (1.05), which was why GaBi and Simapro had greater impacts than openLCA and Umberto 26.…”

Section: Softwarementioning

confidence: 99%

“…Besides being capable of normalization, calculating carbon footprint and environmental impact, SimaPro offers systematic and transparent analysis of cycles with high precision while also being global and easy to model 25. Similarly, GaBi offers normalization tools, too, while also offering databases of its own along with ecoinvent, modeling of cost and social aspects 26. Umberto presents a more modern graphical interface, thus being easier to use while also being compatible with the GaBi database in addition to ecoinvent.…”

Section: Softwarementioning

confidence: 99%

“…Generally applied LCA software also brings out various disadvantages of their own. For example, SimaPro is more demanding on the system space and has a more complicated interface, GaBi presents difficulties with aggregated datasets, Umberto does not allow import/export of datasets to traditional LCA formats, openLCA lacks standard quality databases and requires additional investment to be effectively utilized, while both Umberto and openLCA are lacking normalization and weighting factors 26.…”

Section: Softwarementioning

confidence: 99%

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Sustainable Point of View: Life Cycle Analysis for Green Extraction Technologies

Aslanbay Guler,

Tepe,

Imamoglu

2024

ChemBioEng Reviews

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Microalgae have emerged as a promising source of renewable energy and natural bioproducts since they show high biomass productivity, offer carbon dioxide fixation, and exhibit a rich content of compounds. Recent efforts have focused on green extraction technologies that utilize green solvents to further promote sustainability and minimize the environmental impact of the microalgal process. At this point, life cycle analysis (LCA) provides valuable insights into the environmental impacts of specific products and techniques. A comprehensive overview of the life cycle environmental and energy assessments conducted for the extraction of metabolites from microalgae is presented. Special attention is given to using green extraction technologies, i.e., supercritical fluid extraction, pressurized liquid extraction, microwave‐assisted extraction, ultrasound‐assisted extraction, and pulsed‐electric field extraction, and solvents to ensure sustainability. Additionally, the main principles, historical development, tools, and challenges of LCA are discussed. By addressing these aspects, the paper attracts attention to the environmental impacts associated with green extraction techniques for obtaining microalgal metabolites.

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Section: Softwarementioning

confidence: 99%

Section: Softwarementioning

confidence: 99%

Section: Softwarementioning

confidence: 99%

Section: Softwarementioning

confidence: 99%

Section: Softwarementioning

confidence: 99%

See 3 more Smart Citations

Sustainable Point of View: Life Cycle Analysis for Green Extraction Technologies

Aslanbay Guler,

Tepe,

Imamoglu

2024

ChemBioEng Reviews

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Advancement in SARS-CoV-2 diagnosis: A new and stable electrochemical biosensor for genomic RNA detection

Gomide,

Moço,

Tanaka

et al. 2025

Bioelectrochemistry

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Biological Activity of Late Transition Metal‐Based Compounds: From Computational and Theoretical Studies to Laboratory Exploration and Beyond

Ruwizhi,

Singh,

Omondi

et al. 2024

Bioinorganic Chemistry and Applications

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The use of metal compounds such as cisplatin and its derivatives as therapeutic and diagnostic agents against various diseases is well established. Although metallodrugs have been very successful clinically, low therapeutic selectivity and the potential toxicity of the metal compounds mandate the need for a continuous search for more efficient and specific treatments. Hence, the use of computer‐aided drug design (CADD), molecular modelling and theoretical studies in designing, selecting and applying potential drug candidates have become ever more necessary. Among the many computational and theoretical techniques, molecular docking and density functional theory play significant roles in predicting drug activity. Recent methodologies, within the past 5 years, that rely on these techniques to advance the adoption of potential metallodrugs are highlighted and thoroughly discussed. This is because advancements in computing power have led to the wide use of CADD approaches for drug discovery, development and analysis to shorten the time and reduce the costs associated with drug discovery.

show abstract

Gold(III) heteroleptic complexes with SNS-thiosemicarbazonate ligands as cytotoxic agents: Experimental and computational insights into the mechanism of action

Cited by 4 publications

References 59 publications

Sustainable Point of View: Life Cycle Analysis for Green Extraction Technologies

Sustainable Point of View: Life Cycle Analysis for Green Extraction Technologies

Advancement in SARS-CoV-2 diagnosis: A new and stable electrochemical biosensor for genomic RNA detection

Biological Activity of Late Transition Metal‐Based Compounds: From Computational and Theoretical Studies to Laboratory Exploration and Beyond

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