Gold-iron oxide nanoparticle: A unique multimodal theranostic approach for thrombosis

Fithri, Najma Annuria; Wu, Yuao; Cowin, Gary; Akhter, Fahima; Tran, Huong; Tse, Brian Wan-Chi; Holthe, Nicholas Westra van; Moonshi, Shehzahdi S.; Peter, Karlheinz; Wang, Xiaowei; Truong, Nghia P.; Ta, Hang T.

doi:10.1016/j.apmt.2023.101750

Cited by 10 publications

(7 citation statements)

References 71 publications

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“…However, they are inferior to second-generation drug-eluting stents for angiographic results. [102,103] Other Metal-Based Coatings: Due to its alleged biocompatibility, gold is employed widely for biomedical applications [104] and is preferred in many medical implants without the exception and c,d) the corresponding number of adhered platelets on different substrates. Reproduced with permission.…”

Section: Inorganic Coatingsmentioning

confidence: 99%

“…Due to its alleged biocompatibility, gold is employed widely for biomedical applications [ 104 ] and is preferred in many medical implants without the exception of antithrombotic coatings. [ 105 ] The biocompatibility of stents was supposed to be improved by coating 316L stainless steel with gold, and experimental evidence from animal studies supports this claim.…”

Section: Surface Coating To Prevent Blood Clottingmentioning

confidence: 99%

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Unravelling Surface Modification Strategies for Preventing Medical Device‐Induced Thrombosis

Luu,

Nguyen,

2023

Adv Healthcare Materials

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The use of biomaterials in implanted medical devices remains hampered by platelet adhesion and blood coagulation. Thrombus formation is a prevalent cause of failure of these blood‐contacting devices. Although systemic anticoagulant can be used to support materials and devices with poor blood compatibility, its negative effects such as an increased chance of bleeding, make materials with superior hemocompatibility extremely attractive, especially for long‐term applications. This review examines blood–surface interactions, the pathogenesis of clotting on blood‐contacting medical devices, popular surface modification techniques, mechanisms of action of anticoagulant coatings, and discusses future directions in biomaterial research for preventing thrombosis. In addition, this paper comprehensively reviews several novel methods that either entirely prevent interaction between material surfaces and blood components or regulate the reaction of the coagulation cascade, thrombocytes, and leukocytes.This article is protected by copyright. All rights reserved

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Section: Inorganic Coatingsmentioning

confidence: 99%

Section: Surface Coating To Prevent Blood Clottingmentioning

confidence: 99%

Unravelling Surface Modification Strategies for Preventing Medical Device‐Induced Thrombosis

Luu,

Nguyen,

2023

Adv Healthcare Materials

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“…Plasmonic metals like gold and silver display enhanced photostability and stronger light absorption abilities owing to their unique SPR in comparison to conventional photoabsorbing dyes. 9 Nonetheless, while silver exhibited the highest efficiency of SPR in the visible range, gold NPs have been intensively employed as photothermal agents for treatment in various cancer models. Owing to silver's high efficiency of SPR, Ag represents an appropriate potential alternative based on the enhanced photothermal conversion ability, which translates to enhanced efficacy accompanied by its cost-effectiveness in comparison to gold.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, the unique surface plasmon resonance (SPR) properties of silver present it as a suitable agent for photothermal therapy, whereby conversion of absorbed photons of the laser into heat energy results in temperature elevation. Plasmonic metals like gold and silver display enhanced photostability and stronger light absorption abilities owing to their unique SPR in comparison to conventional photoabsorbing dyes . Nonetheless, while silver exhibited the highest efficiency of SPR in the visible range, gold NPs have been intensively employed as photothermal agents for treatment in various cancer models.…”

Section: Introductionmentioning

confidence: 99%

Spiky Silver–Iron Oxide Nanohybrid for Effective Dual-Imaging and Synergistic Thermo-Chemotherapy

Moonshi,

Vazquez-Prada,

Tang

et al. 2023

ACS Appl. Mater. Interfaces

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Nanophotothermal therapy based on nanoparticles (NPs) that convert near-infrared (NIR) light to generate heat to selectively kill cancer cells has attracted immense interest due to its high efficacy and being free of ionizing radiation damage. Here, for the first time, we have designed a novel nanohybrid, silver−iron oxide NP (AgIONP), which was successfully tuned for strong absorbance at NIR wavelengths to be effective in photothermal treatment and dual-imaging strategy using MRI and photoacoustic imaging (PAI) in a cancer model in vivo and in vitro, respectively. We strategically combine the inherent anticancer activity of silver and photothermal therapy to render excellent therapeutic capability of AgIONPs. In vitro phantoms and in vivo imaging studies displayed preferential uptake of folate-targeted NPs in a cancer mice model, indicating the selective targeting efficiency of NPs. Importantly, a single intravenous injection of NPs in a cancer mice model resulted in significant tumor reduction, and photothermal laser resulted in a further substantial synergistic decrease in tumor size. Additionally, biosafety and biochemical assessment performed in mice displayed no significant difference between NP treatment and control groups. Overall, our folic acid AgIONPs displayed excellent potential in the simultaneous application for safe and successful targeted synergistic photothermal treatment and imaging of a cancer model.

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“…5 Gold nanoparticles have been found to treat thrombosis by affecting fibrin formation, 17 preventing platelet activation, 18 and photothermal thrombolysis. 19 In addition, gold nanoparticles can also target activated neutrophil attachment to treat immunothrombosis associated with neutrophil adhesion in antiphospholipid syndrome. 20 Compared with gold nanoparticles, ultrasmall AuNCs have distinctive physicochemical properties and biological behaviors.…”

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confidence: 99%

Mercaptopyrimidine-templated gold nanoclusters for antithrombotic therapy

Dai,

Lei,

Zhang

et al. 2024

J. Mater. Chem. B

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Gold-iron oxide nanoparticle: A unique multimodal theranostic approach for thrombosis

Cited by 10 publications

References 71 publications

Unravelling Surface Modification Strategies for Preventing Medical Device‐Induced Thrombosis

Unravelling Surface Modification Strategies for Preventing Medical Device‐Induced Thrombosis

Spiky Silver–Iron Oxide Nanohybrid for Effective Dual-Imaging and Synergistic Thermo-Chemotherapy

Mercaptopyrimidine-templated gold nanoclusters for antithrombotic therapy

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