Gold nanoclusters encapsulated microneedle patches with antibacterial and self‐monitoring capacities for wound management

Abstract

The management of infected wounds is always of great significance and urgency in clinical and biomedical fields. Recent efforts in this area are focusing on the development of functional wound patches with effective antibacterial, drug delivery, and sensor properties. Here, we present novel hyaluronic acid (HA) microneedle patches with these features by encapsulating aminobenzeneboronic acid‐modified gold nanoclusters (A‐GNCs) for infected wound management. The A‐GNCs loaded microneedle patches were derived from negative‐mold replication and showed high mechanical strength to penetrate the skin. The release of the A‐GNCs was realized by the degradation of HA, and the self‐monitor of the released actives was based on the dynamic bright orange fluorescence emitted from A‐GNCs under ultraviolet radiation. As the A‐GNCs could destroy bacteria membranes, the microneedle patches were with excellent in vitro antibiosis ability. Based on these features, we have demonstrated the bacteria inhibition, residual drug self‐monitoring, and wound healing promotion abilities of the microneedle patches in Escherichia coli‐ or Staphylococcus aureus‐infected wound management. These results indicated the great potential of such A‐GNCs loaded microneedle patches for clinical applications.

Hydrogel microrobots for biomedical applications

“…(C) The composition and microfluidic 3D printing of PP hybrid bioactive scaffold ( Yang L. et al, 2023 ). (D) Schematic illustration of the aminobenzeneboronic acid-modified gold nanoclusters (A-GNCs) encapsulated fluorescent microneedles array applied to the bacteria-infected skin wounds ( Yi et al, 2024 ). (A) Copyright © 2023, John Wiley and Sons (B) Copyright © 2023 The Authors.…”

“…Wound healing remains a critical issue in clinical and healthcare environments. Zhao et al innovated an encapsulated nanomedicine microneedle array designed for the intelligent management of wounds infected by bacteria ( Yi et al, 2024 ). This advancement involved the preparation of hyaluronic acid (HA) microneedle patches, achieved by encapsulating aminophenylboronic acid-modified gold nanoclusters (A-GNCs) specifically for the treatment of infected wounds, and loading these onto PDMS negative mold replicated HA microneedle substrates, as illustrated in Figure 3D .…”

“…(C) The composition and microfluidic 3D printing of PP hybrid bioactive scaffold (Yang L. et al, 2023). (D) Schematic illustration of the aminobenzeneboronic acid-modified gold nanoclusters (A-GNCs) encapsulated fluorescent microneedles array applied to the bacteria-infected skin wounds (Yi et al, 2024). Frontiers in Chemistry frontiersin.org stimuli to accurately navigate to specific locations to conduct minimally invasive medical procedures or treat diseases.…”