Gold nanoclusters for biomedical applications: toward <i>in vivo</i> studies

Porret, Estelle; Guével, Xavier Le; Coll, Jean‐Luc

doi:10.1039/c9tb02767j

Cited by 114 publications

(105 citation statements)

References 153 publications

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“…However, the penetration depth of green light is even less than NIR and is thus limited in applicability [39]. Due to their theranostic benefits, such as imaging and biosensing, along with therapeutic properties such as drug delivery, gold nanoclusters have emerged as a useful tool [40,41]. The use of gold nanoclusters can allow for molecular imaging, improving diagnostics and imaging in the future [42].…”

Section: Introductionmentioning

confidence: 99%

Advances in Gold Nanoparticle-Based Combined Cancer Therapy

Bromma

Chithrani

2020

Nanomaterials

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According to the global cancer observatory (GLOBOCAN), there are approximately 18 million new cancer cases per year worldwide. Cancer therapies are largely limited to surgery, radiotherapy, and chemotherapy. In radiotherapy and chemotherapy, the maximum tolerated dose is presently being used to treat cancer patients. The integrated development of innovative nanoparticle (NP) based approaches will be a key to address one of the main issues in both radiotherapy and chemotherapy: normal tissue toxicity. Among other inorganic NP systems, gold nanoparticle (GNP) based systems offer the means to further improve chemotherapy through controlled delivery of chemotherapeutics, while local radiotherapy dose can be enhanced by targeting the GNPs to the tumor. There have been over 20 nanotechnology-based therapeutic products approved for clinical use in the past two decades. Hence, the goal of this review is to understand what we have achieved so far and what else we can do to accelerate clinical use of GNP-based therapeutic platforms to minimize normal tissue toxicity while increasing the efficacy of the treatment. Nanomedicine will revolutionize future cancer treatment options and our ultimate goal should be to develop treatments that have minimum side effects, for improving the quality of life of all cancer patients.

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Section: Introductionmentioning

confidence: 99%

Advances in Gold Nanoparticle-Based Combined Cancer Therapy

Bromma

Chithrani

2020

Nanomaterials

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“…This includes for example, their possible toxicity related to the toxicity of their constituents in the case of most QDs and low QYs < 1 % for the organic molecules. A relatively new class of NIR II emitters are ultra-small gold nanoclusters (Au NCs) 7 . Recent studies with Au NCs stabilized by zwitterionic sulfobetaine ligands (AuZw) showing a reasonably high QY (3.8%), enabled to detect blood vessels using photoluminescence (PL) and revealed efficient renal clearance 8 .…”

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confidence: 99%

High-Resolution Shortwave Infrared Imaging of Vascular Disorders Using Gold Nanoclusters

Musnier

Wegner

et al. 2020

ACS Nano

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We synthesized a generation of water-soluble, atomically precise gold nanoclusters (Au NCs) with anisotropic surface containing short dithiol pegylated chain. These Au NCs exhibit a high brightness (QY∼6%) in the shortwave infrared (SWIR) spectrum with a detection above 1250nm and showed a slow elimination from blood with a weak accumulation in organs. We also developed a non-invasive, whole-body vascular imaging system in the SWIR window with high-resolution, benefiting from a series of Monte Carlo image processing of the images. The imaging process enabled to improve contrast by one order of magnitude and enhance by 54% the spatial resolution. After systemic administration of these nanoprobes in mice, we could quantify vessel complexity in depth (>4mm). Using Bmp9 deficient mice, we can detect very subtle vascular disorders noninvasively. The combination of these anisotropic surface charged gold nanoclusters plus an improved SWIR imaging device allows then a precise mapping at high resolution and in depth of the organization of the vascular network in live animals.

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“…The gold clusters, CQDs, and FONs have the potential to be good candidates for probes. [89] The quantum yield of gold clusters and their biocompatible modification requires further improvement. In addition, more strategies for avoiding degradation of probes in cells remain to be developed.…”

Section: Discussionmentioning

confidence: 99%

Principles and Applications of Single Particle Tracking in Cell Research

Zhao

Wang

Zhang

et al. 2021

Small

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It is a tough challenge for many decades to decipher the complex relationships between cell behaviors and cellular physical properties. Single particle tracking (SPT) with high spatial and temporal resolution has been applied extensively in cell research to understand physicochemical properties of cells and their bio‐functions by tracking endogenous or exogenous probes. This review describes the fundamental principles of SPT as well as its applications in intracellular mechanics, membrane dynamics, organelles distribution, and processes of internalization and transport. Finally, challenges and future directions of SPT are also discussed.

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Gold nanoclusters for biomedical applications: toward in vivo studies

Abstract: In parallel with the rapidly growing and widespread use of nanomedicine in the clinic, we are also witnessing the development of so-called theranostic agents that combine diagnostic and therapeutic properties.

Cited by 114 publications

References 153 publications

Advances in Gold Nanoparticle-Based Combined Cancer Therapy

Advances in Gold Nanoparticle-Based Combined Cancer Therapy

High-Resolution Shortwave Infrared Imaging of Vascular Disorders Using Gold Nanoclusters

Principles and Applications of Single Particle Tracking in Cell Research

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