Gold nanoclusters for ratiometric sensing of pH in extremely acidic media

Bonanno, Adele; Pérez-Herráez, Irene; Zaballos-García, Elena; Pérez‐Prieto, Julia

doi:10.1039/c9cc08539d

Cited by 29 publications

(21 citation statements)

References 30 publications

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“…To date, AuNCs have been studied for their potential applications in bioimaging, 8,9 radiofrequency-mediated hyperthermia, 10 optoelectronics, 11 and sensing. 12,13 AuNCs are typically synthesized by either top-down or bottom-up approaches. In both methodologies, because of their strong affinity toward gold, thiol-containing ligands, including small molecules, polymers, and proteins, have been most widely used as capping agents to produce AuNCs.…”

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confidence: 99%

Engineering Fluorescent Gold Nanoclusters Using Xanthate-Functionalized Hydrophilic Polymers: Toward Enhanced Monodispersity and Stability

et al. 2020

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We introduce xanthate-functionalized poly(cyclic imino ethers)s (PCIEs), specifically poly(2-ethyl-2-oxazoline) and poly(2-ethyl-2oxazine) given their stealth characteristics, as an attractive alternative to conventional thiol-based ligands for the synthesis of highly monodisperse and fluorescent gold nanoclusters (AuNCs). The xanthate in the PCIEs interacts with Au ions, acting as a well-controlled template for the direct formation of PCIE-AuNCs. This method yields red-emitting AuNCs with a narrow emission peak (λ em = 645 nm), good quantum yield (4.3−4.8%), long fluorescence decay time (∼722−844 ns), and unprecedented product yield (>98%). The PCIE-AuNCs exhibit long-term colloidal stability, biocompatibility, and antifouling properties, enabling a prolonged blood circulation, lower nonspecific accumulation in major organs, and better renal clearance when compared with AuNCs without polymer coating. The advances made here in the synthesis of metal nanoclusters using xanthate-functionalized PCIEs could propel the production of highly monodisperse, biocompatible, and renally clearable nanoprobes in large-scale for different theranostic applications.

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confidence: 99%

Engineering Fluorescent Gold Nanoclusters Using Xanthate-Functionalized Hydrophilic Polymers: Toward Enhanced Monodispersity and Stability

et al. 2020

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“…These measurements suggest that NAD interacts with the gold surface through the nicotinamide moiety, corroborating previous results. 25 The NAD-Au interaction is further confirmed by photoluminescence of nanoparticles 26 through the emission band at 400 nm (Figure 2f). It should be noted that of NAD(H) retains chemical integrity during the dark reaction, as demonstrated by NMR analysis of the oxidized and reduced cofactor in the presence of metallic precursor (Figure S3).…”

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confidence: 72%

Coupling plasmonic catalysis and nanocrystal growth through cyclic regeneration of NADH

2021

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“…Since all these attributes can affect the electron transfer process between the ligands and the metal core, it is not surprising that the pH value has an effect on the luminescence of MNCs. [62] The rigidity of the surrounding environment of MNCs also plays a critical role in regulating the luminescence of MNCs. This is because that the motion of surface ligands of MNCs is largely affected by the rigidity of the surrounding solvent.…”

Section: Luminescence Propertiesmentioning

confidence: 99%

Luminescent metal nanoclusters: Biosensing strategies and bioimaging applications

et al. 2021

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Metal nanoclusters (MNCs) are ultrasmall metal‐organic aggregates, composed of a metal core less than 2 nm and a protecting shell of metal‐organic ligand motifs. The controlled aggregation of metal atoms (in the cluster core) and metal‐organic ligand motifs (around the cluster core) renders MNCs with numerous molecule‐like properties, among which strong and bright luminescence has attracted extensive basic and applied interests. It has now known that aggregation‐induced emission is a feasible mechanism for controlling luminescence of MNCs, which makes it particularly useful in biosensing and bioimaging applications. Although the luminescence fundamentals and design principles largely determine the practicality and effectiveness of MNCs in biosensing and bioimaging applications, a systematic summary of this topic is lacking in the current literature. In this review, we aim to provide a concise discussion of the latest developments in biosensing and bioimaging applications of luminescent MNCs, highlighting their luminescence mechanisms, biosensing principles, and bioimaging strategies. Specifically, we first introduce the recent advances in the synthetic chemistry of MNCs, and then briefly discuss the luminescence fundamentals of MNCs. Then the design strategy and practicality of luminescent MNCs in biosensing and bioimaging applications are exemplified. We conclude the review with our perspectives on the further development of MNC‐based optical probes in biosensing and bioimaging applications. Our review is expected to provide guidance for the future practice of designing and synthesizing luminescent MNCs for biomedical and other applications.

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Gold nanoclusters for ratiometric sensing of pH in extremely acidic media

Abstract: AuNCs capped with β-nicotinamide adenine dinucleotide phosphate exhibit an outstanding performance as ratiometric, fluorescent pH sensors in extremely acid media (0.6–2.7) and in the 7.0–9.2 pH range; the nanocluster itself is the fluorophore.

Cited by 29 publications

References 30 publications

Engineering Fluorescent Gold Nanoclusters Using Xanthate-Functionalized Hydrophilic Polymers: Toward Enhanced Monodispersity and Stability

Engineering Fluorescent Gold Nanoclusters Using Xanthate-Functionalized Hydrophilic Polymers: Toward Enhanced Monodispersity and Stability

Coupling plasmonic catalysis and nanocrystal growth through cyclic regeneration of NADH

Luminescent metal nanoclusters: Biosensing strategies and bioimaging applications

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