Gold nanoflowers synthesized using Acanthopanacis cortex extract inhibit inflammatory mediators in LPS-induced RAW264.7 macrophages via NF-κB and AP-1 pathways

Ahn, Sungeun; Singh, Priyanka; Jang, Mi Hyeon; Kim, Yujin; Castro-Aceituno, Verónica; Simu, Shakina Yesmin; Kim, Yeon Ju; Yang, Deok‐Chun

doi:10.1016/j.colsurfb.2017.11.037

Cited by 60 publications

(40 citation statements)

References 29 publications

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“…The synthesis was first monitored by the visual color change in the reaction mixture, followed by the spectral analysis [18]. After the complete reduction in metal salts to nanoparticles, the nanoparticles were purified by centrifugation, first at 2000 rpm for 5 min, which allowed removing the large particulates, followed by a second round of centrifugation at 14,000 rpm for 15 min to collect the nanoparticles [18,21]. The obtained nanoparticles were washed thoroughly with distilled water to remove the unconverted metal ions or any other reaction constituents.…”

Section: Green Synthesis Of Aunps and Agnpsmentioning

confidence: 99%

“…Plant components such as polysaccharides, flavonoids, terpenoids, polyphenols, amino acids, alkaloids, organic acids and vitamins are all known to contribute to reducing metals salts to form nanoparticles and/or capping and stabilizing the produced nanoparticles [26,31]. AuNPs and AgNPs were synthesized successfully, as indicated by the color change in the reaction suspension from light yellow to deep purple for AuNPs and brown for AgNPs (Figure 1) [21,32,33]. The synthesis of nanoparticles was confirmed by a wavelength scan (300-700 nm) of the nanoparticles suspension.…”

Section: Green Synthesis Of Nanoparticlesmentioning

confidence: 99%

“…Terpenoids, which are a class of diverse organic polymers found in plants, have been suggested to be accountable for the reduction of silver and gold ions into nanoparticles [31,45]. Similarly, flavonoids possess various functional groups, which are capable of reducing metal ions into nanoparticles [21,45].…”

Section: Nanoparticles Surface Contains Biomolecules From the R Rosementioning

confidence: 99%

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Anti-biofilm effects of gold and silver nanoparticles synthesized by the Rhodiola rosea rhizome extracts

Singh

Pandit

Beshay

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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115

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Bacterial biofilm represents a major problem in medicine. They colonize and damage medical devices and implants and, in many cases, foster development of multidrug-resistant microorganisms. Biofilm development starts by bacterial attachment to the surface and the production of extracellular polymeric substances (EPS). The EPS forms a structural scaffold for dividing bacterial cells. The EPS layers also play a protective role, preventing the access of antibiotics to biofilm-associated microorganisms. The aim of this work was to investigate the production nanoparticles that could be used to inhibit biofilm formation. The applied production procedure from rhizome extracts of Rhodiola rosea is simple and environmentally friendly, as it requires no additional reducing, stabilizing and capping agents. The produced nanoparticles were stable and crystalline in nature with an average diameter of 13-17 nm for gold nanoparticles (AuNPs) and 15-30 nm for silver nanoparticles (AgNPs). Inductively coupled plasma mass spectrometry analysis revealed the concentration of synthesized nanoparticles as 3.3 and 5.3 mg/ ml for AuNPs and AgNPs, respectively. Fourier-transform infrared spectroscopy detected the presence of flavonoids, terpenes and phenols on the nanoparticle surface, which could be responsible for reducing the Au and Ag salts to nanoparticles and further stabilizing them. Furthermore, we explored the AgNPs for inhibition of Pseudomonas aeruginosa and Escherichia coli biofilms. AgNPs exhibited minimum inhibitory concentrations of 50 and 100 mg/ml, against P. aeruginosa and E. coli, respectively. The respective minimum bactericidal concentrations were 100 and 200 mg/ml. These results suggest that using the rhizome extracts of the medicinal plant R. rosea represents a viable route for green production of nanoparticles with anti-biofilm effects.

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Section: Green Synthesis Of Aunps and Agnpsmentioning

confidence: 99%

Section: Green Synthesis Of Nanoparticlesmentioning

confidence: 99%

Section: Nanoparticles Surface Contains Biomolecules From the R Rosementioning

confidence: 99%

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Anti-biofilm effects of gold and silver nanoparticles synthesized by the Rhodiola rosea rhizome extracts

Singh

Pandit

Beshay

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

Self Cite

115

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“…Mechanisms of these nanoparticles include metal ion release, and oxidative and non-oxidative stress being active at the same time [17]. These mechanisms caused membrane degradation, deterioration of cellular and so on [18]. Silver nanoparticles (Ag NPs) are among these inorganic agents, which is non-toxic, prepared from silver metal, and having bactericidal, antiviral and antifungal effects at low concentrations [19].…”

Section: Introductionmentioning

confidence: 99%

Down-Regulation of fliL Gene Expression by Ag Nanoparticles and TiO2 Nanoparticles in Pragmatic Clinical Isolates of Proteus mirabilis and Proteus vulgaris from Urinary Tract Infection

Saleh¹,

Malik²,

Al-Rubaii³

2019

Nano BioMed ENG

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Ten isolates belonging to Proteus spp. were collected and obtained from Department of Biology, College of Science, the University of Baghdad. The diagnosis was done by polymerase chain reaction (PCR) technique using 16S rRNA gene and urease C gene. All isolates (100%) were sensitive to meropenem, imipenem, ciprofloxacin, gentamycin, amoxicillin, clavulanic acid and levofloxacin. These isolates also showed 60% sensitivity to cefixime and nitrofurantoin. However, both species of P. mirabilis and P. vulgaris showed the lowest sensitivity when treated with tetracycline (60%) and amikacin (20%). Cephalothin had a variable effect on the species under study as P. mirabilis isolates were 100% sensitive in comparison with the 80% sensitivity of P. vulgaris isolates. The antibacterial activities of Ag and TiO 2 nanoparticles (NPs) were investigated. The minimum inhibitory concentration (MIC) value of Ag NPs against both species isolates was 10 mg/mL, while the MIC value of TiO 2 NPs was 14 mg/mL against P. mirabilis and 15 mg/mL against P. vulgaris isolates. P. mirabilis isolates showed larger swarming diameter than P. vulgaris, but this motility phenomenon of P. vulgaris was arrested rapidly after incubation with sub-MIC of TiO 2 NPs and Ag NPs comparatively with control. All isolates showed shifting to down-regulation in the fliL gene expression under the effect of the NPs using TiO 2 NPs and Ag NPs. In conclusion, down-regulation of the fliL gene expression is directly linked to the inhibition of swarming movement of Proteus species. We encourage using these inhibitors (after tests to ensure minimal toxicity to human) in combination with antibiotics to ensure bactericidal /bacteriostatic effect to treat Proteus infections.

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“…Plants-mediated synthesis of core-shell nanoparticles is advantageous when compared to processes that are assisted by bacteria and fungi [36]. Prasad et al (2017) [37] reported one-step biosynthesized magnetic nickel/iron-oxide core shell NPs using 20 grams of Moringa oleifera extract.…”

Section: Greener Synthesis Of Core-shell Nanoparticles Using Plantsmentioning

confidence: 99%

Core@shell Nanoparticles: Greener Synthesis Using Natural Plant Products

et al. 2018

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Featured Application: Greener synthesis and applications of Core-shell nanoparticles.Abstract: Among an array of hybrid nanoparticles, core-shell nanoparticles comprise of two or more materials, such as metals and biomolecules, wherein one of them forms the core at the center, while the other material/materials that were located around the central core develops a shell. Core-shell nanostructures are useful entities with high thermal and chemical stability, lower toxicity, greater solubility, and higher permeability to specific target cells. Plant or natural products-mediated synthesis of nanostructures refers to the use of plants or its extracts for the synthesis of nanostructures, an emerging field of sustainable nanotechnology. Various physiochemical and greener methods have been advanced for the synthesis of nanostructures, in contrast to conventional approaches that require the use of synthetic compounds for the assembly of nanostructures. Although several biological resources have been exploited for the synthesis of core-shell nanoparticles, but plant-based materials appear to be the ideal candidates for large-scale green synthesis of core-shell nanoparticles. This review summarizes the known strategies for the greener production of core-shell nanoparticles using plants extract or their derivatives and highlights their salient attributes, such as low costs, the lack of dependence on the use of any toxic materials, and the environmental friendliness for the sustainable assembly of stabile nanostructures.

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Gold nanoflowers synthesized using Acanthopanacis cortex extract inhibit inflammatory mediators in LPS-induced RAW264.7 macrophages via NF-κB and AP-1 pathways

Cited by 60 publications

References 29 publications

Anti-biofilm effects of gold and silver nanoparticles synthesized by the Rhodiola rosea rhizome extracts

Anti-biofilm effects of gold and silver nanoparticles synthesized by the Rhodiola rosea rhizome extracts

Down-Regulation of fliL Gene Expression by Ag Nanoparticles and TiO2 Nanoparticles in Pragmatic Clinical Isolates of Proteus mirabilis and Proteus vulgaris from Urinary Tract Infection

Core@shell Nanoparticles: Greener Synthesis Using Natural Plant Products

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