Gold Nanoparticle-assisted Selective Photothermolysis of Adipose Tissue (NanoLipo)

Sheng, Wangzhong; Alhasan, Ali H.; DiBernardo, Gabriella; Almutairi, Khalid; Rubin, J. Peter; DiBernardo, Barry E.; Almutairi, Adah

doi:10.1097/gox.0000000000000251

Cited by 19 publications

(23 citation statements)

References 23 publications

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“…Exploiting the PT-based cancer therapy concept, Adah Almutairi, professor at the University San Diego have developed a system for [130]. Copyright 2014, with permission from Elsevier fat removal using NPs-based liposuction [133], called «NanoLipo». This technology relies on the selective and local heating of adipose tissue upon external near-infrared laser exposure of AuNR allowing the fat to be liquefied and easily aspirated.…”

Section: Aunps-based Photothermal Therapymentioning

confidence: 99%

Recent advances using gold nanoparticles as a promising multimodal tool for tissue engineering and regenerative medicine

Vial¹,

Reis²,

Oliveira³

2017

Current Opinion in Solid State and Materials Science

144

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Gold nanoparticles (AuNPs) have arisen a lot of interest in the clinical realms of nanomedicine. Despite the large advances made in cancer research using AuNPs, their use in tissue engineering and regenerative medicine (TERM) is still in its infancy. Herein, it is discussed the properties, functionalization, and emerging use of AuNPs as a multifunctional and multimodal platform for drug delivery, phototherapy, diagnostic and cell imaging purposes. Moreover, the recent reports related to the ability of AuNPs to enhance stem cell differentiation for bone tissue engineering, to enhance the mechanical and adhesive properties of scaffolds and surface topography to guide cell behaviors are addressed.

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Section: Aunps-based Photothermal Therapymentioning

confidence: 99%

Recent advances using gold nanoparticles as a promising multimodal tool for tissue engineering and regenerative medicine

Vial¹,

Reis²,

Oliveira³

2017

Current Opinion in Solid State and Materials Science

144

View full text Add to dashboard Cite

show abstract

“…These engineering principles formed the foundation and continued to serve as the guiding principles for the development of laser-based cosmetic technologies. 72 Although SPT applied toward endogenous species does not overcome the problem of penetration depth, the unique ability to confine heat to specific targetable pigmented structures, while sparing the surrounding tissue, could prove extremely powerful in the context of practical PTT. In the case of PT heating of exogenous species, the major advantage, and challenge, is that one could create an absorbing structure by virtue of where the PT absorber is introduced.…”

Section: Biological Optical Windowmentioning

confidence: 99%

“…74 We have found examples in the literature where researchers have carefully considered how light is best applied based on the geometry of the target structures in order to maximize the specificity of the light-based application. 5,16,72,75,76 Furthermore, our own research lab is attempting to leverage this phenomenon in the context of liposuction to modulate heating of adipose tissues to aid in their removal by plastic surgeons. 72…”

Section: Biological Optical Windowmentioning

confidence: 99%

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Review of the progress toward achieving heat confinement—the holy grail of photothermal therapy

Sheng

Seare³

et al. 2017

J. Biomed. Opt

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Photothermal therapy (PTT) involves the application of normally benign light wavelengths in combination with efficient photothermal (PT) agents that convert the absorbed light to heat to ablate selected cancers. The major challenge in PTT is the ability to confine heating and thus direct cellular death to precisely where PT agents are located. The dominant strategy in the field has been to create large libraries of PT agents with increased absorption capabilities and to enhance their delivery and accumulation to achieve sufficiently high concentrations in the tissue targets of interest. While the challenge of material confinement is important for achieving “heat and lethality confinement,” this review article suggests another key prospective strategy to make this goal a reality. In this approach, equal emphasis is placed on selecting parameters of light exposure, including wavelength, duration, power density, and total power supplied, based on the intrinsic properties and geometry of tissue targets that influence heat dissipation, to truly achieve heat confinement. This review highlights significant milestones researchers have achieved, as well as examples that suggest future research directions, in this promising technique, as it becomes more relevant in clinical cancer therapy and other noncancer applications.

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“…However, a major distinction from cancer therapies is that in NanoLipo, GNPs are injected at concentrations orders of magnitude lower than those used in PTT (1.2 OD for NanoLipo vs 50 OD for PTT), since the goal is not complete tissue destruction. 10 Another important distinction between NanoLipo and cancer therapies that rely on bulk heating is that the laser energy in NanoLipo is applied for strategically predetermined pulse durations and optimized power outputs, leveraging known heating relaxation times for the GNPs and affected target fat structures. NanoLipo is thereby able to specifically disrupt the fibroconnective tissues and lipocytes through selective photothermolysis.…”

mentioning

confidence: 99%

A Single-Blind Study Evaluating the Efficacy of Gold Nanoparticle Photothermal-Assisted Liposuction in an Ex Vivo Human Tissue Model

Sheng¹,

Seare²,

DiBernardo³

et al. 2018

Aesthetic Surgery Journal

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Background: Liposuction is one of the most performed cosmetic surgery procedures. In a previously reported study, gold-nanoparticle (GNP) laser-assisted liposuction (NanoLipo) was shown to improve procedure parameters and outcomes in a porcine model. Objectives: An ex vivo human liposuction model was developed to assess the ease, efficacy, and outcomes of NanoLipo, and to further explore its mechanism of action in facilitating liposuction. Methods: NanoLipo was compared to a control without GNPs in sets of fresh, nonperfused, anatomically symmetric, matched tissue specimens from 12 patients. A subset of three experiments was performed under single-blinded conditions. Intraoperative assessments included lipoaspirate volume, percentage of free oil, ease of removal, and temperature rise. Specimens were palpated, visualized for evenness, and graded with and without skin. Postoperative assessment included viability staining of the lipoaspirate and remaining tissues. Microcomputed tomography was used to assess the distribution of infused GNPs within the tissues. Results: NanoLipo consistently removed more adipose tissue with more liberated triglycerides compared to control. NanoLipo specimens were smoother, thinner, and had fewer and smaller irregularities. Infused solutions preferentially distributed between fibrous membranes and fat pearls. After NanoLipo, selective structural-tissue disruptions, indicated by loss of metabolic activity, were observed. Thus, NanoLipo likely creates a bimodal mechanism of action whereby fat lobules are dislodged from surrounding fibro-connective tissue, while lipolysis is simultaneously induced. Conclusions: NanoLipo showed many advantages compared to control under blinded and nonblinded conditions. This technology may be promising in facilitating fat removal.

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Gold Nanoparticle-assisted Selective Photothermolysis of Adipose Tissue (NanoLipo)

Abstract: Supplemental Digital Content is available in the text.

Cited by 19 publications

References 23 publications

Recent advances using gold nanoparticles as a promising multimodal tool for tissue engineering and regenerative medicine

Recent advances using gold nanoparticles as a promising multimodal tool for tissue engineering and regenerative medicine

Review of the progress toward achieving heat confinement—the holy grail of photothermal therapy

A Single-Blind Study Evaluating the Efficacy of Gold Nanoparticle Photothermal-Assisted Liposuction in an Ex Vivo Human Tissue Model

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