Gold nanoparticle based colorimetric probe for dopamine detection based on the interaction between dopamine and melamine

Abstract

We report on a probe for the colorimetric and bareeye detection of dopamine (DA). The optical effect is based on the finding that DA inhibits the melamine-induced aggregation of red gold nanoparticles (AuNPs) to form blue AuNP clusters. We presume that the aggregation induced by melamine is due to its strong hydrogen-bonding interactions with DA. The color changes can be monitored by spectrophotometry or the bare eye. The probes works over the 33 nM to 3.33 mM DA concentration range, and levels down to 33 nM can be quantified. The nanoprobe was successfully applied to the determination of DA in spiked serum.

A Review of Gold and Silver Nanoparticle‐Based Colorimetric Sensing Assays

“…Carbohydrate-protein interactions NR [26] AuNPs ( Spiked serum DA inhibits melamine-induced AuNP aggregation LOD: 33 nM LDR: 33-3.33 mM [12] AuNPs (13 nm) Monodisperse…”

Rapid determination of dopamine in human plasma using a gold nanoparticle-based dual-mode sensing system

“…Several colorimetric methods based on the distance-dependent optical properties of AuNPs have been developed for dopamine detection. The color variation of AuNPs associated with the reversible process from dispersion to aggregation induced by the intermolecular interactions between dopamine and surface modifiers on the AuNPs can be observed by naked eyes and quantified by UV-vis spectra [18][19][20][21][22]. In addition, several fluorometric assays have been demonstrated for the detection of dopamine with high sensitivity using fluorophores such as calcein blue-Fe 2+ complex [23], carbon dots [24], silicon nanoparticles [25], molecule capped QDs [26][27][28][29], and gold nanoclusters (AuNCs) [30,31].…”

Spectrophotometric and visual detection of the herbicide atrazine by exploiting hydrogen bond-induced aggregation of melamine-modified gold nanoparticles

“…These prepared Mel-AuNPs can remain stable and sensitive [29,30]. Figure 1 illustrates the mechanism for the colorimetric sensing of atrazine.…”

“…However, a low concentration of melamine may simply absorb onto the surface of AuNPs and induce no obvious change in its dispersion state [29,30]. In addition, melamine-gold nanoparticles (Mel-AuNPs) may be formed by a hydrogen-bonding interaction between β-agonists [29,30] and melamine.…”