Gold nanoparticle-based nanoprobes with enhanced tumor targeting and photothermal/photodynamic response for therapy of osteosarcoma

Abstract

Abastract Plasmonic nanomaterials, especially a wide variety of gold nanoparticles, demonstrate great potential for theranostics of cancer. Herein, a gold nanotriangle with CD133 and hyaluronic acid on its surface loaded with a near-infrared photosensitizer was prepared for enhanced photodynamic/photothermal combined anti-tumor therapy. CD133 and hyaluronic acid provide the nanoprobe with dual tumor targeting, while the hyaluronic acid also protects photosensitive drugs from photodegradation. Thus, the nanoprobe has enhanced photothermal/photodynamic effects. This integrated treatment strategy significantly enhanced photodynamic/photothermal destruction of osteosarcoma cells. In addition, this treatment, induced by mild irradiation with a single wavelength laser, inhibited tumor growth in an osteosarcoma mouse model. These results indicate that this systemic treatment strategy can achieve enhanced anti-tumor therapeutic effects through active tumor targeting and protection of the loaded drugs.

Graphene Oxide Nanoparticle–Loaded Ginsenoside Rg3 Improves Photodynamic Therapy in Inhibiting Malignant Progression and Stemness of Osteosarcoma

“…AgBiS 2-nanoparticles combined with photodynamic treatment improved the phototherapy for malignant osteosarcoma (Cheng et al, 2020). Gold nanoparticles enhance photothermal/photodynamic treatment response for osteosarcoma (Xiong et al, 2021). Meanwhile, the anti-cancer activities of Rg3 in the development of osteosarcoma has been well recognized.…”

Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential

“…The synergetic therapeutic outcomes could be ascribed to photothermal alleviation of tumor hypoxia though improving blood flow, thus enhancing photodynamic effect [ 229 ]. In the combination therapy, NPs can endow multiple functions including live imaging [ [230] , [231] , [232] ], tumor targeting [ 29 , 233 , 234 ], and TME-/thermal-responsive drug release [ 98 , 235 , 236 ]. These functions make it possible to achieve theranostics and enhance therapeutic efficiency.…”

Clinical progress of nanomedicine-based RNA therapies

“…trehalose [ 90 ], targeting ligands, e.g. peptides, sugars, or antibodies [ [91] , [92] , [93] ], and/or endosomal escape moieties, e.g. trileucine [ 94 ], can potentially overcome these common issues.…”