Gold Nanoparticle‐Carrying T Cells for the Combined Immuno‐Photothermal Therapy

Kim, Hye‐Mi; Baek, Yujin; Ha, Taeyong; Choi, Dohoon; Lee, Woojin; Cho, Yongbum; Park, Jeehun; Kim, Sungjee; Doh, Junsang

doi:10.1002/smll.202301377

Cited by 10 publications

(3 citation statements)

References 50 publications

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“…Besides the strategies for PTT combined with immunotherapy, nanoparticles for targeting antigen-capturing DCs, 157 AuNPs-carrying T cells for ACT and PTT 158 have been proposed. Antigen-capturing DC-targeting nanoparticles were synthesized using mannose-modified TLR agonist-loaded PDA, and the modified PDA was coated with liposomes.…”

Section: External Stimulimentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanomedicine for Enhanced Cancer Immunotherapy

Kim,

Lee,

et al. 2024

Chem. Mater.

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Cancer immunotherapy, aimed at reinvigorating the immune system to induce a lasting anticancer response, has emerged as a promising approach for counteracting the evasive tactics of cancer cells. This study delves into the innovative realm of stimuli-responsive polymeric nanomedicines in the context of cancer immunotherapy. By capitalizing on the intricate landscape of the tumor microenvironment (TME), which orchestrates immune suppression and tumor progression, stimuli-responsive nanomedicines offer a tailored strategy to enhance therapeutic interventions. The aberrant features of the TME, which include factors such as low pH, inflammation, oxidative stress, and enzyme overexpression, serve as triggers for intelligent delivery systems facilitated by functional polymers. This dynamic approach has the potential to overcome the challenges faced by traditional nanoparticle-based immunotherapy techniques, presenting a platform to precisely optimize drug delivery within the tumor locale. As the synergistic interaction between stimuli-responsive polymeric nanomedicines and the TME unfolds, a novel horizon emerges to advance the efficacy of cancer immunotherapy while mitigating its associated limitations.

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Section: External Stimulimentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanomedicine for Enhanced Cancer Immunotherapy

Kim,

Lee,

et al. 2024

Chem. Mater.

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“…The local high temperatures generated by noble metal nanoparticles can directly disrupt the structure and function of tumor cells, causing protein denaturation, cell membrane damage, and even destruction of cellular organelles, such as mitochondrial dysfunction thus leading to an insufficient energy supply. Of course, the local thermal effect can also lead to cell death in a variety of ways, including necrosis (death of cells that are damaged to the point that they are unable to sustain life activities) and apoptosis (programmed cell death, controlled by intracellular signaling pathways) [ 22 ]. Apart from these, high temperatures may also trigger cellular autophagy and inflammatory responses.…”

Section: Mechanistic Study Of Noble Metal Nanoparticles For Photother...mentioning

confidence: 99%

“…This polarization serves to remodel the immunosuppressive tumor microenvironment into an antitumor milieu, thereby further augmenting the efficacy of immunotherapy. HyeMi Kim et al integrated adoptive cell therapy (ACT) with photothermal therapy (PTT) by incorporating AuNPs into tumor-reactive T cells, which were then administered intravenously [ 22 ]. The AuNP-loaded T cells migrated to the tumor tissues and initiated the elimination of tumor cells.…”

Section: Noble Metal Nanomaterials In Cancer Therapymentioning

confidence: 99%

Noble Metal Nanoparticle-Based Photothermal Therapy: Development and Application in Effective Cancer Therapy

Yu,

Xia,

Yang

et al. 2024

IJMS

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Photothermal therapy (PTT) is a promising cancer therapy modality with significant advantages such as precise targeting, convenient drug delivery, better efficacy, and minimal adverse effects. Photothermal therapy effectively absorbs the photothermal transducers in the near-infrared region (NIR), which induces the photothermal effect to work. Although PTT has a better role in tumor therapy, it also suffers from low photothermal conversion efficiency, biosafety, and incomplete tumor elimination. Therefore, the use of nanomaterials themselves as photosensitizers, the targeted modification of nanomaterials to improve targeting efficiency, or the combined use of nanomaterials with other therapies can improve the therapeutic effects and reduce side effects. Notably, noble metal nanomaterials have attracted much attention in PTT because they have strong surface plasmon resonance and an effective absorbance light at specific near-infrared wavelengths. Therefore, they can be used as excellent photosensitizers to mediate photothermal conversion and improve its efficiency. This paper provides a comprehensive review of the key role played by noble metal nanomaterials in tumor photothermal therapy. It also describes the major challenges encountered during the implementation of photothermal therapy.

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Flower‐Like Nanosensors for Photoacoustic‐Enhanced Lysosomal Escape and Cytoplasmic Marker‐Activated Fluorescence: Enabling High‐Contrast Identification and Photothermal Ablation of Minimal Residual Disease in Breast Cancer

Li,

Xing,

Chen

et al. 2024

Adv Healthcare Materials

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The clearance of minimal residual disease (MRD) after breast cancer surgery is crucial for inhibiting metastasis and recurrence. However, the most promising biomarker‐activated fluorescence imaging strategies encounter accessibility issues of the delivered sensors to cytoplasmic targets. Herein, a flower‐like composite nanosensor with photoacoustic (PA) effect‐enhanced lysosomal escape and cytoplasmic marker‐activated fluorescence is developed to address this challenge. Specifically, the incorporation of Co2+ into the synthesis of 2D Zn2+‐derived metal–organic frameworks enabled rapid dopamine polymerization and deposition. Subsequently, the composite nanoflower (FHN), characterized by an average size of ≈80 nm and petal thickness of ≈6 nm, is formed through the sealing of micropores and simultaneous cross‐linking of nanosheets. The pronounced reduction in thermal conductivity of FHN, and superposition of interpetal thermal fields under a pulsed laser (PL), lead to enhanced PA effect and membrane permeability. Thereby, nanosensors efficiently escape from lysosomes resulting in synergistic fluorescence activation by dual‐factors (ATP, miRNA‐21) and DNA probes installed on FHN. A subsequently high tumor‐to‐normal tissue signal ratio (TNR) of 17.4 lead to precise guidance of NIR irradiation for efficient MRD eradication and recurrence inhibition. This study provides a new approach for high‐contrast identification and precise ablation of MRD based on the synergistic response of endogenous and exogenous factors.

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Gold Nanoparticle‐Carrying T Cells for the Combined Immuno‐Photothermal Therapy

Cited by 10 publications

References 50 publications

Stimuli-Responsive Polymeric Nanomedicine for Enhanced Cancer Immunotherapy

Stimuli-Responsive Polymeric Nanomedicine for Enhanced Cancer Immunotherapy

Noble Metal Nanoparticle-Based Photothermal Therapy: Development and Application in Effective Cancer Therapy

Flower‐Like Nanosensors for Photoacoustic‐Enhanced Lysosomal Escape and Cytoplasmic Marker‐Activated Fluorescence: Enabling High‐Contrast Identification and Photothermal Ablation of Minimal Residual Disease in Breast Cancer

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