Gold nanoparticle-cored poly(propyleneimine) dendrimers as a new platform for multifunctional drug delivery systems

Daniel, Marie‐Christine; Grow, Margaret E.; Pan, Hongmu; Bednarek, Maria A.; Ghann, William; Zabetakis, Kara; Cornish, Joseph P.

doi:10.1039/c1nj20206e

Cited by 41 publications

(37 citation statements)

References 68 publications

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“…With this aim, a platform of cationic carbosilane dendrons with different focal points were designed and different materials were functionalized, such as poly(D, L-lactide-co-glycolide) acid (PLGA) nanoparticles, 31 mesoporous silica, 32 4 or also were decorated with a fluorescent label. 35 Nevertheless, interactions with cell compounds and compartments are nonselective, with the risk of causing cyto-and hemo-toxicity mainly due to their surface charge. 34 Herein, we report on the synthesis of AuNPs capped with cationic carbosilane dendrons possessing a thiol function at the focal point.…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles stabilized by cationic carbosilane dendrons: synthesis and biological properties

et al. 2017

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Gold nanoparticles (AuNPs) and polycationic macromolecules are used as gene carriers. Their behaviour is dependent on several factors, such as the size and type of the framework, charge, etc. We have combined both types of systems and prepared AuNPs covered with cationic carbosilane dendrons with the aim to evaluate their biocompatibility. Water soluble dendronized cationic AuNPs were prepared following a straightforward procedure from dendrons, a gold precursor and a reducing agent in water and were characterized by H NMR, transmission electron microscopy (TEM), dynamic light scattering (DLS), thermogravimetric analysis (TGA), ultraviolet spectroscopy (UV), and zeta potential (ZP). The biological properties of dendrons and AuNPs were determined by hemolysis, platelet aggregation and lymphocyte proliferation. These assays reflect modification of dendron properties when covering nanoparticles. For dendrons, hemolysis and platelet aggregation are generation dependent whilst, for AuNPs these properties are related to the bigger size of NPs. On the other hand, none of the systems induced lymphocyte proliferation. Selected cationic dendrons and AuNPs were chosen for gene delivery experiments employing a small interference RNA (siRNA Nef) against human immunodeficiency virus (HIV).

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Section: Introductionmentioning

confidence: 99%

Gold nanoparticles stabilized by cationic carbosilane dendrons: synthesis and biological properties

et al. 2017

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“…Gold nanoparticles display a variety of properties [7] and have important applications as diverse as cosmetics [8], electronics [9], therapeutics [10][11][12], imaging [13,14], drug delivery [15,16], and pollution remediation [17,18]. The mentioned applications often call for monodisperse nanoparticles of a particular size in large quantities and/or at high concentrations [19,20].…”

Section: Introductionmentioning

confidence: 99%

Effect of high gold salt concentrations on the size and polydispersity of gold nanoparticles prepared by an extended Turkevich–Frens method

et al. 2012

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The Turkevich-Frens synthesis starting conditions are expanded, ranging the gold salt concentrations up to 2 mM and citrate/gold(III) molar ratios up to 18:1. For each concentration of the initial gold salt solution, the citrate/gold(III) molar ratios are systematically varied from 2:1 to 18:1 and both the size and size distribution of the resulting gold nanoparticles are compared. This study reveals a different nanoparticle size evolution for gold salt solutions ranging below 0.8 mM compared to the case of gold salt solutions above 0.8 mM. In the case of [Au 3+ ]<0.8 mM, both the size and size distribution vary substantially with the citrate/gold(III) ratio, both displaying plateaux that evolve inversely to [Au 3+ ] at larger ratios. Conversely, for [Au 3+ ]≥0.8 mM, the size and size distribution of the synthesized gold nanoparticles continuously rise as the citrate/gold(III) ratio is increased. A starting gold salt concentration of 0.6 mM leads to the formation of the most monodisperse gold nanoparticles (polydispersity index< 0.1) for a wide range of citrate/gold(III) molar ratios (from 4:1 to 18:1). Via a model for the formation of gold nanoparticles by the citrate method, the experimental trends in size could be qualitatively predicted: the simulations showed that the destabilizing effect of increased electrolyte concentration at high initial [Au 3+ ] is compensated by a slight increase in zeta potential of gold nanoparticles to produce concentrated dispersion of gold nanoparticles of small sizes.

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“…[56,57] Reports related to dendron/dendrimer-stabilized PdNPs for hydrogenation have appeared, for catalysts in which the PdNPs are not located at the dendrimer core but stabilized by nitrogen ligands between the dendrimer tethers. [20,58,59] It is well known, however, that neutral nitrogen bases are very weak ligands for NP surfaces. Indeed, such PdNPs stabilized by nitrogen bases are good or excellent hydrogenation catalysts, because the nitrogen base is very easily displaced on the NP surface by olefinic substrates and dihydrogen.…”

Section: Resultsmentioning

confidence: 99%

“…After filtration through Celite and washing with ethanol and acetone, the resulting black solid was extracted with toluene. The black filtrate was then filtered through Celite, and the solvents were evaporated in vacuo to provide 2 as a black colloid (20 3 ). [59,64,65] The number of units of 1 per particle, n s , can then be deduced from the relation: n s = N Pd /X = 118/2.3 = 51.…”

Section: Methodsmentioning

confidence: 99%

Catalytically Active Palladium Nanoparticle‐Cored Ferrocenyl‐Terminated Dendrimers

Astruc

2015

Eur J Inorg Chem

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Nanoparticle-cored (NP-cored) ferrocenyl dendrimers are precise multifunctional supramolecular nanomaterials owing to their active central and terminal groups and high (1Ǟ3) branching connectivity. For instance, catalysis in the interior of the metallodendrimer remains intriguing, especially because sulfur ligands have the reputation to inhibit catalytic reactions on surfaces. A nonaferrocenyl thiol dendron, 1, was utilized to prepare PdNP-cored metallodendrimers (FcD-

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Gold nanoparticle-cored poly(propyleneimine) dendrimers as a new platform for multifunctional drug delivery systems

Cited by 41 publications

References 68 publications

Gold nanoparticles stabilized by cationic carbosilane dendrons: synthesis and biological properties

Gold nanoparticles stabilized by cationic carbosilane dendrons: synthesis and biological properties

Effect of high gold salt concentrations on the size and polydispersity of gold nanoparticles prepared by an extended Turkevich–Frens method

Catalytically Active Palladium Nanoparticle‐Cored Ferrocenyl‐Terminated Dendrimers

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